William H. Gaze
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View article: Escape from antimicrobial CRISPR-Cas9 in <i>E. coli</i> ST131 depends on the genetic context of the target gene
Escape from antimicrobial CRISPR-Cas9 in <i>E. coli</i> ST131 depends on the genetic context of the target gene Open
Escherichia coli ( E. coli ) is a common bacterium in the human gut and an important cause of intestinal and extraintestinal infections. Some E. coli sequence types (ST) are associated with high pathogenicity. The Extraintestinal Pathogeni…
View article: CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred Open
Bacteria can encode dozens of different immune systems that protect them from infection by mobile genetic elements (MGEs). MGEs themselves may also carry immune systems, such as CRISPR-Cas, to target competitor MGEs. It is unclear when thi…
View article: Antimicrobial effects, and selection for AMR by non-antibiotic drugs in a wastewater bacterial community
Antimicrobial effects, and selection for AMR by non-antibiotic drugs in a wastewater bacterial community Open
Antimicrobial resistance (AMR) is a major threat to human, animal, and crop health. AMR can be directly selected for by antibiotics, and indirectly co-selected for by biocides and metals, at environmentally relevant concentrations. Some ev…
View article: Common non-antibiotic drugs enhance selection for antimicrobial resistance in mixture with ciprofloxacin
Common non-antibiotic drugs enhance selection for antimicrobial resistance in mixture with ciprofloxacin Open
Antimicrobial resistance (AMR) is a major health concern, and a range of antibiotic and non-antibiotic agents can select for AMR across a range of concentrations. Selection for AMR is often investigated using single compounds, however, in …
View article: Recreational exposure to polluted open water and infection: A systematic review and meta-analysis protocol
Recreational exposure to polluted open water and infection: A systematic review and meta-analysis protocol Open
We present a peer-reviewed protocol for a systematic review and meta-analysis of exposure to wastewater and runoff pollution and infection in recreational open water users in the Global North. Eligible studies must contain at least two gro…
View article: Investigating landscape-scale variables impacting human exposure to antibiotic resistant bacteria using a targeted metagenome approach
Investigating landscape-scale variables impacting human exposure to antibiotic resistant bacteria using a targeted metagenome approach Open
Research has shown that exposure to coastal waters containing antibiotic resistant bacteria (ARB) is associated with higher likelihood of gut colonisation by ARB. The aim was to identify landscape-scale processes contributing to the spread…
View article: Common non-antibiotic drugs enhance selection for antimicrobial resistance in mixture with ciprofloxacin
Common non-antibiotic drugs enhance selection for antimicrobial resistance in mixture with ciprofloxacin Open
Antimicrobial resistance (AMR) is a major health concern, and a range of antibiotic and non-antibiotic agents can select for AMR across a range of concentrations. Selection for AMR is often investigated using single compounds, however, in …
View article: Antimicrobial risk assessment–Aggregating aquatic chemical and resistome emissions
Antimicrobial risk assessment–Aggregating aquatic chemical and resistome emissions Open
Urban water systems receive and emit antimicrobial chemicals, resistant bacterial strains, and resistance genes (ARGs), thus representing "antimicrobial hotspots". Currently, regional environmental risk assessment (ERA) is carried out usin…
View article: Microcosm experiment investigating climate-induced thermal effects on human virus viability in seawater: qPCR vs capsid integrity for enhanced risk management
Microcosm experiment investigating climate-induced thermal effects on human virus viability in seawater: qPCR vs capsid integrity for enhanced risk management Open
Climate change is intensifying extreme weather events in coastal areas, leading to more frequent discharge of untreated wastewater containing human viruses into coastal waters. This poses a health risk, especially during heatwaves when bat…
View article: A critical meta-analysis of predicted no effect concentrations for antimicrobial resistance selection in the environment
A critical meta-analysis of predicted no effect concentrations for antimicrobial resistance selection in the environment Open
Antimicrobial resistance (AMR) is one of the greatest threats to human health with a growing body of evidence demonstrating that selection for AMR can occur at environmental antimicrobial concentrations. Understanding the concentrations at…
View article: Opportunities and challenges in antimicrobial resistance policy including animal production systems and humans across stakeholders in Argentina: a context and qualitative analysis
Opportunities and challenges in antimicrobial resistance policy including animal production systems and humans across stakeholders in Argentina: a context and qualitative analysis Open
Introduction Gaps in antimicrobial resistance (AMR) surveillance and control, including implementation of national action plans (NAPs), are evident internationally. Countries’ capacity to translate political commitment into action is cruci…
View article: Co-selection for antibiotic resistance by environmental contaminants
Co-selection for antibiotic resistance by environmental contaminants Open
View article: Metabarcoding of Hepatitis E Virus Genotype 3 and Norovirus GII from Wastewater Samples in England Using Nanopore Sequencing
Metabarcoding of Hepatitis E Virus Genotype 3 and Norovirus GII from Wastewater Samples in England Using Nanopore Sequencing Open
Norovirus is one of the largest causes of gastroenteritis worldwide, and Hepatitis E virus (HEV) is an emerging pathogen that has become the most dominant cause of acute viral hepatitis in recent years. The presence of norovirus and HEV ha…
View article: Uncovering the prevalence and drivers of antibiotic resistance genes in soils across different land-use types
Uncovering the prevalence and drivers of antibiotic resistance genes in soils across different land-use types Open
View article: Interspecific competition can drive plasmid loss from a focal species in a microbial community
Interspecific competition can drive plasmid loss from a focal species in a microbial community Open
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, and it is therefore critical to predict and reduce plasmid spread within microbial communities. The cost of plasmid carriage is a key metric that can b…
View article: The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogen <i>Pseudomonas aeruginosa</i>
The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogen <i>Pseudomonas aeruginosa</i> Open
Anthropogenic metal pollution can result in co‐selection for antibiotic resistance and potentially select for increased virulence in bacterial pathogens. Metal‐polluted environments can select for the increased production of siderophore mo…
View article: The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogen Pseudomonas aeruginosa: data
The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogen Pseudomonas aeruginosa: data Open
Data for 'The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogen Pseudomonas aeruginosa' published in Evolutionary Applications. This tests whether liming reduces selection by m…
View article: Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples
Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples Open
Surveillance of antibiotic resistance genes (ARGs) has been increasingly conducted in environmental sectors to complement the surveys in human and animal sectors under the "One-Health" framework. However, there are substantial challenges i…
View article: Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool
Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool Open
Graphical Abstract A broad host-range CRISPR-Cas9 delivery tool was developed and used to conjugatively remove antimicrobial resistance (AMR) plasmids (top) and protect a series of coliform and Pseudomonas isolates from AMR plasmid uptake …
View article: Assessing the impact of recreational water use on carriage of antimicrobial resistant organisms
Assessing the impact of recreational water use on carriage of antimicrobial resistant organisms Open
View article: Assessing the Impact of Recreational Water Use on Carriage of Antimicrobial Resistant Organisms
Assessing the Impact of Recreational Water Use on Carriage of Antimicrobial Resistant Organisms Open
View article: Functional metagenomic libraries generated from anthropogenically impacted environments reveal importance of metabolic genes in biocide and antibiotic resistance
Functional metagenomic libraries generated from anthropogenically impacted environments reveal importance of metabolic genes in biocide and antibiotic resistance Open
View article: The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment
The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment Open
Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly un…
View article: EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach
EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach Open
View article: First, do no harm: time for a systems approach to address the problem of health-care-derived pharmaceutical pollution
First, do no harm: time for a systems approach to address the problem of health-care-derived pharmaceutical pollution Open
View article: The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogen <i>Pseudomonas aeruginosa</i>
The effect of metal remediation on the virulence and antimicrobial resistance of the opportunistic pathogen <i>Pseudomonas aeruginosa</i> Open
Metal contamination poses both a direct threat to human health as well as an indirect threat through its potential to affect bacterial pathogens. Metals can not only co-select for antibiotic resistance, but also might affect pathogen virul…
View article: Predicting selection for antimicrobial resistance in UK wastewater and aquatic environments: Ciprofloxacin poses a significant risk
Predicting selection for antimicrobial resistance in UK wastewater and aquatic environments: Ciprofloxacin poses a significant risk Open
View article: A Sonic Net deters European starlings <i>Sturnus vulgaris</i> from maize silage stores
A Sonic Net deters European starlings <i>Sturnus vulgaris</i> from maize silage stores Open
Deterrents against avian pest species might be more effective if they were based on some aspect of the target species' sensory salience. Sonic Nets broadcast a loud and spatially‐ focused pink noise that spans the frequency range of the ta…
View article: Non-antibiotic pharmaceuticals promote conjugative plasmid transfer at a community-wide level
Non-antibiotic pharmaceuticals promote conjugative plasmid transfer at a community-wide level Open
View article: The distribution of antimicrobial resistance genes across phylogroup, host species and geography in 16,000 publicly-available<i>E. coli</i>genomes
The distribution of antimicrobial resistance genes across phylogroup, host species and geography in 16,000 publicly-available<i>E. coli</i>genomes Open
E. coli is a highly diverse bacterial species that generates a huge global burden of antimicrobial-resistant infections. A wealth of whole genome sequence data is available on public databases for this species, presenting new opportunities…