William Hind
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View article: Preclinical evaluation of cannabidiolic acid as a neuroprotective agent in TDP-43 transgenic mice, an experimental model of amyotrophic lateral sclerosis
Preclinical evaluation of cannabidiolic acid as a neuroprotective agent in TDP-43 transgenic mice, an experimental model of amyotrophic lateral sclerosis Open
Plant-derived cannabinoids, including Δ9-THC, cannabinol, and Sativex-like combinations, have shown neuroprotection in preclinical ALS models. However, minor phytocannabinoids like cannabidiolic acid (CBDA) remain unexplored. This study ev…
View article: Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy
Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy Open
Therapeutic hypothermia is well established as a standard treatment for infants with hypoxic-ischemic (HI) encephalopathy but it is only partially effective. The potential for combination treatments to augment hypothermic neuroprotection h…
View article: Cannabidiol Reduces Inflammatory Lung Damage After Meconium Aspiration in Newborn Piglets
Cannabidiol Reduces Inflammatory Lung Damage After Meconium Aspiration in Newborn Piglets Open
Aim To assess the effects of cannabidiol (CBD) on lung damage in a piglet model of meconium aspiration syndrome (MAS). Materials and Methods Meconium aspiration syndrome was modelled in newborn piglets via intratracheal instillation of 20%…
View article: Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis
Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis Open
The innate immune response to bacterial and viral molecules involves the coordinated production of cytokines, chemokines, and type I interferons (IFNs), which is orchestrated by toll-like receptors (TLRs). TLRs, and their intracellular sig…
View article: Phytocannabinoid‐dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity
Phytocannabinoid‐dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity Open
Background and Purpose Cannabidiol (CBD) has been shown to differentially regulate the mechanistic target of rapamycin complex 1 (mTORC1) in preclinical models of disease, where it reduces activity in models of epilepsies and cancer and in…
View article: Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats
Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats Open
Neonatal hypoxia-ischemia (HI) is a risk factor for myelination disturbances, a key factor for cerebral palsy. Cannabidiol (CBD) protects neurons and glial cells after HI insult in newborn animals. We hereby aimed to study CBD's effects on…
View article: Cannabidiol protects an <i>in vitro</i> model of the blood–brain barrier from oxygen‐glucose deprivation via PPARγ and 5‐HT<sub>1A</sub> receptors
Cannabidiol protects an <i>in vitro</i> model of the blood–brain barrier from oxygen‐glucose deprivation via PPARγ and 5‐HT<sub>1A</sub> receptors Open
Background and Purpose In vivo and in vitro studies have demonstrated a protective effect of cannabidiol (CBD) in reducing infarct size in stroke models and against epithelial barrier damage in numerous disease models. We aimed to investig…
View article: Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB<sub>1</sub>activation
Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB<sub>1</sub>activation Open
This study shows, for the first time, that CBD causes vasorelaxation of human mesenteric arteries via activation of CB1 and TRP channels, and is endothelium- and nitric oxide-dependent.
View article: Endocannabinoids modulate human blood–brain barrier permeability <i>in vitro</i>
Endocannabinoids modulate human blood–brain barrier permeability <i>in vitro</i> Open
Background and Purpose Endocannabinoids alter permeability at various epithelial barriers, and cannabinoid receptors and endocannabinoid levels are elevated by stroke, with potential neuroprotective effects. We therefore explored the role …