William J. Betz
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View article: A conserved<i>Plasmodium</i>protein that localizes to liver stage nuclei is critical for late liver stage development
A conserved<i>Plasmodium</i>protein that localizes to liver stage nuclei is critical for late liver stage development Open
Malaria, the disease caused by Plasmodium parasites, causes significant mortality and morbidity. Whole parasite vaccination with pre-erythrocytic parasite stages, attenuated through sporozoite irradiation or chemo-attenuation, confers ster…
View article: A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony
A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony Open
View article: A replication-competent late liver stage–attenuated human malaria parasite
A replication-competent late liver stage–attenuated human malaria parasite Open
Whole-sporozoite vaccines engender sterilizing immunity against malaria in animal models and importantly, in humans. Gene editing allows for the removal of specific parasite genes, enabling generation of genetically attenuated parasite (GA…
View article: Intracerebral tuberculomas: A rare cause of seizure in an immunocompetent young male
Intracerebral tuberculomas: A rare cause of seizure in an immunocompetent young male Open
View article: The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes
The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes Open
Within the liver, Plasmodium sporozoites traverse cells searching for a "suitable" hepatocyte, invading these cells through a process that results in the formation of a parasitophorous vacuole (PV), within which the parasite undergo…
View article: Assessing drug efficacy against Plasmodium falciparum liver stages in vivo
Assessing drug efficacy against Plasmodium falciparum liver stages in vivo Open
Malaria eradication necessitates new tools to fight the evolving and complex Plasmodium pathogens. These tools include prophylactic drugs that eliminate Plasmodium liver stages and consequently prevent clinical disease, decrease transmissi…