William J. Olney
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View article: Fixed dose daptomycin: An opportunity for pharmacokinetic/pharmacodynamic optimization in <i>Staphylococcus aureus</i> infections
Fixed dose daptomycin: An opportunity for pharmacokinetic/pharmacodynamic optimization in <i>Staphylococcus aureus</i> infections Open
Background Daptomycin is a high‐use intravenous antimicrobial agent affording the convenience of once‐daily dosing. Prior studies suggest an opportunity to use a more operationally convenient fixed rather than weight‐based dosing but this …
View article: 2554. What’s Weight Got to Do with It? Prospective Pharmacokinetic/Pharmacodynamic Evaluation of Fixed-Dose Daptomycin
2554. What’s Weight Got to Do with It? Prospective Pharmacokinetic/Pharmacodynamic Evaluation of Fixed-Dose Daptomycin Open
Background As daptomycin (DAP) CL does not scale proportionally with weight, fixed-dose DAP has been proposed to optimize efficacy and mitigate toxicity. This study evaluated systemic exposure of a fixed dose (750 mg) of DAP in patients wi…
View article: Medication Regimen Complexity Score as an Indicator of Fluid Balance in Critically Ill Patients
Medication Regimen Complexity Score as an Indicator of Fluid Balance in Critically Ill Patients Open
Background: Critically ill patients are at increased risk for fluid overload, but objective prediction tools to guide clinical decision-making are lacking. The MRC-ICU scoring tool is an objective tool for measuring medication regimen comp…
View article: High-Dose Daptomycin and Clinical Applications
High-Dose Daptomycin and Clinical Applications Open
Objective: To evaluate evidence for high-dose daptomycin (doses ≥ 8 mg/kg/d). Data Sources: A PubMed/MEDLINE literature search was performed (January 2000 to December 2020) using the search terms daptomycin, high dose, and dosing. Review a…