William James Deardorff
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View article: Development of a Mortality Prediction Model for Incarcerated Adults to Identify Palliative Care Needs
Development of a Mortality Prediction Model for Incarcerated Adults to Identify Palliative Care Needs Open
Background Estimating mortality risk in incarcerated adults is important for identifying individuals who may benefit from palliative care and compassionate release referrals. Objective To develop and internally validate a 2-year mortality …
View article: Decision-Making and Downstream Outcomes of the Gabapentinoid-Diuretic Prescribing Cascade
Decision-Making and Downstream Outcomes of the Gabapentinoid-Diuretic Prescribing Cascade Open
Importance Prescribing cascades are an underrecognized driver of polypharmacy among older adults (aged ≥65 years). The clinical decision-making processes underlying cascades and their downstream consequences are poorly understood. Objectiv…
View article: Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade
Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade Open
Background Loop diuretic (LD) use may lead to a prescribing cascade whereby urinary symptoms are ascribed to genitourinary syndromes and treated with urinary symptom medications (USMs). We investigated if LDs lead to increased USM use amon…
View article: Household Wealth and Potentially Inappropriate Medications in Persons With Dementia: Role of Comorbidities and Caregivers
Household Wealth and Potentially Inappropriate Medications in Persons With Dementia: Role of Comorbidities and Caregivers Open
Background The association between lower socioeconomic status and increased potentially inappropriate medications (PIMs) among older adults, as seen in some studies, is infrequently studied in persons with dementia (PWD). This association …
View article: “Nobody Can Be Equipped for This”: Advice From New Residents of Long‐Term Care Facilities
“Nobody Can Be Equipped for This”: Advice From New Residents of Long‐Term Care Facilities Open
Background The transition into a long‐term care facility (LTCF) is difficult for older adults, prompting calls for clinicians to help guide and plan. Yet we know little about how those with lived experience of moving into an LTCF would adv…
View article: External Validation of the Walter Index for Posthospitalization Mortality Prediction in Older Adults
External Validation of the Walter Index for Posthospitalization Mortality Prediction in Older Adults Open
Importance The Walter Index is a widely used prognostic tool for assessing 12-month mortality risk among hospitalized older adults. Developed in the US in 2001, its accuracy in contemporary non-US contexts is unclear. Objective To evaluate…
View article: Physician- and Large Language Model-Generated Hospital Discharge Summaries: A Blinded, Comparative Quality and Safety Study
Physician- and Large Language Model-Generated Hospital Discharge Summaries: A Blinded, Comparative Quality and Safety Study Open
Importance High quality discharge summaries are associated with improved patient outcomes but contribute to clinical documentation burden. Large language models (LLMs) provide an opportunity to support physicians by drafting discharge summ…
View article: Deprescribing of Antihypertensive Medications and Cognitive Function in Nursing Home Residents
Deprescribing of Antihypertensive Medications and Cognitive Function in Nursing Home Residents Open
Importance Antihypertensive medication deprescribing is common among nursing home residents, yet its association with cognitive decline remains uncertain. Objective To investigate the association of deprescribing antihypertensive medicatio…
View article: Impact of Hospitalizations on Problematic Medication Use Among Community-Dwelling Persons With Dementia
Impact of Hospitalizations on Problematic Medication Use Among Community-Dwelling Persons With Dementia Open
Background Hospitalizations are frequently disruptive for persons with dementia (PWD) in part due to the use of potentially problematic medications for complications such as delirium, pain, and insomnia. We sought to determine the impact o…
View article: Use of a Financial Incentive Code for In-Home COVID-19 Vaccination of Homebound Older Adults
Use of a Financial Incentive Code for In-Home COVID-19 Vaccination of Homebound Older Adults Open
This study evaluated the uptake of Healthcare Common Procedure Coding System code M0201 after initial implementation to inform future policy related to in-home preventive care.
View article: From bedside‐to‐model: Designing clinical prediction rules for implementation
From bedside‐to‐model: Designing clinical prediction rules for implementation Open
This editorial comments on the article by Herasevich et al .
View article: Which older adults are at highest risk of prescribing cascades? A national study of the gabapentinoid–loop diuretic cascade
Which older adults are at highest risk of prescribing cascades? A national study of the gabapentinoid–loop diuretic cascade Open
Background Prescribing cascades are important contributors to polypharmacy. Little is known about which older adults are at highest risk of experiencing prescribing cascades. We explored which older veterans are at highest risk of the gaba…
View article: Development and External Validation of Models to Predict Need for Nursing Home Level of Care in Community-Dwelling Older Adults With Dementia
Development and External Validation of Models to Predict Need for Nursing Home Level of Care in Community-Dwelling Older Adults With Dementia Open
Importance Most older adults living with dementia ultimately need nursing home level of care (NHLOC). Objective To develop models to predict need for NHLOC among older adults with probable dementia using self-report and proxy reports to ai…
View article: Around the <scp>EQUATOR</scp> with <scp>Clin‐STAR</scp> : Prediction modeling opportunities and challenges in aging research
Around the <span>EQUATOR</span> with <span>Clin‐STAR</span> : Prediction modeling opportunities and challenges in aging research Open
The 2015 Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) Statement was published to improve reporting transparency for prediction modeling studies. The objective of this review is to…
View article: Frequency of Screening for Colorectal Cancer by Predicted Life Expectancy Among Adults 76-85 Years
Frequency of Screening for Colorectal Cancer by Predicted Life Expectancy Among Adults 76-85 Years Open
This study assesses whether colorectal cancer screening varied by predicted life expectancy in a national sample of Veterans Affairs patients aged 76 to 85 years.
View article: Medication misuse and overuse in community‐dwelling persons with dementia
Medication misuse and overuse in community‐dwelling persons with dementia Open
Background Persons with dementia (PWD) have high rates of polypharmacy. While previous studies have examined specific types of problematic medication use in PWD, we sought to characterize a broad spectrum of medication misuse and overuse a…
View article: Error in Text
Error in Text Open
In Reply We appreciate the letter from Dr Mooldijk and colleagues regarding our study 1 that reported on the development and external validation of a mortality prediction model for community-dwelling older adults with dementia.Their letter…
View article: Improving Clinical Applicability of Mortality Prediction Models Among Persons With Dementia—Reply
Improving Clinical Applicability of Mortality Prediction Models Among Persons With Dementia—Reply Open
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAM…
View article: UNNECESSARY AND HARMFUL MEDICATION USE IN COMMUNITY DWELLING PERSONS WITH DEMENTIA
UNNECESSARY AND HARMFUL MEDICATION USE IN COMMUNITY DWELLING PERSONS WITH DEMENTIA Open
Persons with dementia (PWD) often have multiple comorbidities which results in extensive medication use despite potentially limited benefit and increased risk of adverse events. Compared to the nursing home, little is known about medicatio…
View article: Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia
Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia Open
Importance Estimating mortality risk in older adults with dementia is important for guiding decisions such as cancer screening, treatment of new and chronic medical conditions, and advance care planning. Objective To develop and externally…
View article: Fingerstick glucose monitoring by cognitive impairment status in Veterans Affairs nursing home residents with diabetes
Fingerstick glucose monitoring by cognitive impairment status in Veterans Affairs nursing home residents with diabetes Open
Background Guidelines recommend nursing home (NH) residents with cognitive impairment receive less intensive glycemic treatment and less frequent fingerstick monitoring. Our objective was to determine whether current practice aligns with g…
View article: Do functional status and Medicare claims data improve the predictive accuracy of an electronic health record mortality index? Findings from a national Veterans Affairs cohort
Do functional status and Medicare claims data improve the predictive accuracy of an electronic health record mortality index? Findings from a national Veterans Affairs cohort Open
Background Electronic health record (EHR) prediction models may be easier to use in busy clinical settings since EHR data can be auto-populated into models. This study assessed whether adding functional status and/or Medicare claims data (…
View article: Comparing Machine Learning to Regression Methods for Mortality Prediction Using Veterans Affairs Electronic Health Record Clinical Data
Comparing Machine Learning to Regression Methods for Mortality Prediction Using Veterans Affairs Electronic Health Record Clinical Data Open
Background: It is unclear whether machine learning methods yield more accurate electronic health record (EHR) prediction models compared with traditional regression methods. Objective: The objective of this study was to compare machine lea…
View article: Mild cognitive impairment as a clinical and research outcome: Ready for prime time?
Mild cognitive impairment as a clinical and research outcome: Ready for prime time? Open
This editorial comments on the article by Gaussoin et al . in this issue.
View article: Time to Benefit of Bisphosphonate Therapy for the Prevention of Fractures Among Postmenopausal Women With Osteoporosis
Time to Benefit of Bisphosphonate Therapy for the Prevention of Fractures Among Postmenopausal Women With Osteoporosis Open
This meta-analysis found that the TTB of bisphosphonate therapy was 12.4 months to prevent 1 nonvertebral fracture per 100 postmenopausal women with osteoporosis. These results suggest that bisphosphonate therapy is most likely to benefit …
View article: <scp>COVID</scp> ‐19, masks, and hearing difficulty: Perspectives of healthcare providers
<span>COVID</span> ‐19, masks, and hearing difficulty: Perspectives of healthcare providers Open
Hearing loss is common among adults and associated with increased healthcare utilization and miscommunications that lead to adverse events.1-4 Despite its importance, hearing loss is often unrecognized or underappreciated.5 In response to …
View article: Hospitalization Risk Among Older Adults with Sensory Impairments: Development of a Prognostic Model
Hospitalization Risk Among Older Adults with Sensory Impairments: Development of a Prognostic Model Open
OBJECTIVES To develop a prognostic model for hospital admissions over a 1‐year period among community‐dwelling older adults with self‐reported hearing and/or vision impairments based on readily obtainable clinical predictors. DESIGN Retros…
View article: Regulation of Iron Homeostasis through Parkin-Mediated Lactoferrin Ubiquitylation
Regulation of Iron Homeostasis through Parkin-Mediated Lactoferrin Ubiquitylation Open
Somatic mutations that perturb Parkin ubiquitin ligase activity and the misregulation of iron homeostasis have both been linked to Parkinson's disease. Lactotransferrin (LTF) is a member of the family of transferrin iron binding proteins t…