William Larry Gluck
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View article: Effects of chemotherapy on skeletal muscle mitochondrial oxidative capacity using near-infrared spectroscopy (NIRS): Protocol paper for an observational mixed model repeated measures design in patients with breast and gynecological cancer
Effects of chemotherapy on skeletal muscle mitochondrial oxidative capacity using near-infrared spectroscopy (NIRS): Protocol paper for an observational mixed model repeated measures design in patients with breast and gynecological cancer Open
Mitochondrial dysfunction, a hallmark of metabolic disturbances in the skeletal muscle, has previously been studied in health participants using invasive muscle biopsy and/or time consuming, high-cost magnetic resonance spectroscopy. Howev…
View article: Effects of chemotherapy on skeletal muscle mitochondrial oxidative capacity using Near-Infrared Spectroscopy (NIRS): Protocol paper for an observational mixed model repeated measures design in patients with breast and gynecological cancer
Effects of chemotherapy on skeletal muscle mitochondrial oxidative capacity using Near-Infrared Spectroscopy (NIRS): Protocol paper for an observational mixed model repeated measures design in patients with breast and gynecological cancer Open
Chemotherapy-associated cachexia results in significant metabolic disturbances and loss of skeletal muscle. These physiologic effects increase fatigue, reduce physical functioning, and decrease quality of life in patients undergoing treatm…
View article: Efficacy of Therapeutic Plasma Exchange Alone or in Combination with Ruxolitinib for the Treatment of Penn Class 3 and 4 Cytokine Release Syndrome Complicating COVID-19
Efficacy of Therapeutic Plasma Exchange Alone or in Combination with Ruxolitinib for the Treatment of Penn Class 3 and 4 Cytokine Release Syndrome Complicating COVID-19 Open
This study was conducted to validate the efficacy of therapeutic plasma exchange (TPE) in reducing the excessive cytokine load complicating a subset of patients with severe COVID-19 and respiratory compromise. Additionally, this trial expl…
View article: A Phase<scp>II</scp>Study of Durvalumab in Combination with Tremelimumab in Patients with Rare Cancers
A Phase<span>II</span>Study of Durvalumab in Combination with Tremelimumab in Patients with Rare Cancers Open
Lessons Learned Disease control with signals of response were demonstrated, which should lead to future validating clinical trials using checkpoint inhibitors in this underserved rare malignancy population. Although the study of single typ…
View article: Efficacy of therapeutic plasma exchange in the treatment of penn class 3 and 4 cytokine release syndrome complicating COVID-19
Efficacy of therapeutic plasma exchange in the treatment of penn class 3 and 4 cytokine release syndrome complicating COVID-19 Open
ClinicalTrials.gov NCT04374149.
View article: Prolonged response of widely metastatic HER2-positive colon cancer to trastuzumab therapy
Prolonged response of widely metastatic HER2-positive colon cancer to trastuzumab therapy Open
Emerging evidence suggests a small subset of late-stage colon cancer driven by HER2, a biomarker routinely evaluated in select breast and gastric cancers, may respond to HER2-targeted therapy. Herein, we describe a 49-year-old male with wi…