William Lopes
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View article: A Potent Fluorescent Derivative of 8-Hydroxyquinoline Suggests Cell Wall Damage as a Possible Cellular Action of the 5-Triazole 8-Hydroxyquinoline Class
A Potent Fluorescent Derivative of 8-Hydroxyquinoline Suggests Cell Wall Damage as a Possible Cellular Action of the 5-Triazole 8-Hydroxyquinoline Class Open
Fungal infections are a major but often neglected global health challenge, affecting both human health and agricultural productivity. Current treatments are limited by few drug classes and increasing multidrug resistance, exacerbated by th…
View article: Reduced growth and biofilm formation at high temperatures contribute to <i>Cryptococcus deneoformans</i> dermatotropism
Reduced growth and biofilm formation at high temperatures contribute to <i>Cryptococcus deneoformans</i> dermatotropism Open
Cryptococcus deneoformans (Cd) and C. neoformans (Cn) differ in geographic prevalence and dermatotropism, with Cd strains more commonly isolated from temperate regions and skin infections. Rising global temperatures prompt concerns regardi…
View article: Multistability driven by cooperative growth in microbial communities
Multistability driven by cooperative growth in microbial communities Open
Microbial communities often exhibit more than one possible stable composition for the same set of external conditions 1-7 . In the human microbiome, persistent changes in species composition and abundance are associated with health and dis…
View article: Scanning electron microscopy and machine learning reveal heterogeneity in capsular morphotypes of the human pathogen Cryptococcus spp.
Scanning electron microscopy and machine learning reveal heterogeneity in capsular morphotypes of the human pathogen Cryptococcus spp. Open
Phenotypic heterogeneity is an important trait for the development and survival of many microorganisms including the yeast Cryptococcus spp., a deadly pathogen spread worldwide. Here, we have applied scanning electron microscopy (SEM) to d…
View article: A Highly Active Triterpene Derivative Capable of Biofilm Damage to Control Cryptococcus spp.
A Highly Active Triterpene Derivative Capable of Biofilm Damage to Control Cryptococcus spp. Open
Cryptococcus neoformans is an encapsulated yeast responsible for more than 180,000 deaths per year. The standard therapeutic approach against cryptococcosis is a combination of amphotericin B with flucytosine. In countries where cryptococc…
View article: Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride
Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride Open
Summary Background Fungal infections are highly prevalent and are responsible for high rates of morbidity and mortality. In this context, the search for new treatment alternatives is very relevant. Objectives Analyse chemical compounds for…
View article: Invasion of Human Nails by Microsporum canis
Invasion of Human Nails by Microsporum canis Open
We report the invasion of the human nail plate by the dermatophytic species Microsporum canis, which was recently described as a biofilm former, in Scanning Electron Microscopy (SEM) images.With the images it was possible to evidence the p…
View article: Nanoemulsion Improves the Antifungal Activity of Allylic Thiocyanates against Yeasts and Filamentous Pathogenic Fungi
Nanoemulsion Improves the Antifungal Activity of Allylic Thiocyanates against Yeasts and Filamentous Pathogenic Fungi Open
We report the antifungal and antichemotactic activities of a series of allylic thiocyanates with low toxicity. We also show improved antifungal activity of the most promising compound when used in a nanoemulsion (NE). The 4‐chlorophenyl‐su…
View article: A Predicted Mannoprotein Participates in Cryptococcus gattii Capsular Structure
A Predicted Mannoprotein Participates in Cryptococcus gattii Capsular Structure Open
Cryptococcus gattii has the ability to escape from the host’s immune system through poorly understood mechanisms and can lead to the death of healthy individuals. The role of mannoproteins in C. gattii pathogenicity is not completely under…
View article: Geometrical Distribution of Cryptococcus neoformans Mediates Flower-Like Biofilm Development
Geometrical Distribution of Cryptococcus neoformans Mediates Flower-Like Biofilm Development Open
Microbial biofilms are highly structured and dynamic communities in which phenotypic diversification allows microorganisms to adapt to different environments under distinct conditions. The environmentally ubiquitous pathogen Cryptococcus n…
View article: Cryptococcal dissemination to the central nervous system requires the vacuolar calcium transporter Pmc1
Cryptococcal dissemination to the central nervous system requires the vacuolar calcium transporter Pmc1 Open
Cryptococcus neoformans is a basidiomycetous yeast and the cause of cryptococcosis in immunocompromised individuals. The most severe form of the disease is meningoencephalitis, which is one of the leading causes of death in HIV/AIDS patien…
View article: UV-Surface Treatment of Fungal Resistant Polyether Polyurethane Film-Induced Growth of Entomopathogenic Fungi
UV-Surface Treatment of Fungal Resistant Polyether Polyurethane Film-Induced Growth of Entomopathogenic Fungi Open
Synthetic polymers are the cause of some major environmental impacts due to their low degradation rates. Polyurethanes (PU) are widely used synthetic polymers, and their growing use in industry has produced an increase in plastic waste. A …
View article: The Anti-helminthic Compound Mebendazole Has Multiple Antifungal Effects against Cryptococcus neoformans
The Anti-helminthic Compound Mebendazole Has Multiple Antifungal Effects against Cryptococcus neoformans Open
Cryptococcus neoformans is the most lethal pathogen of the central nervous system. The gold standard treatment of cryptococcosis, a combination of amphotericin B with 5-fluorocytosine, involves broad toxicity, high costs, low efficacy, and…
View article: Cohesive geometry of Cryptococcus neoformans distribution mediates flower-like biofilm development
Cohesive geometry of Cryptococcus neoformans distribution mediates flower-like biofilm development Open
Microbial biofilms are highly structured and dynamic communities, in which phenotypic diversification allows microorganisms to adapt to different environments under distinct conditions. Biofilms are ubiquitous in nature and colonize many n…