William Mannherz
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View article: Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex
Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex Open
Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibit telomere maintenance in cancer cells …
View article: <i>In cellulo</i> DNA assembly for targeted genomic integration and rearrangement in human cells
<i>In cellulo</i> DNA assembly for targeted genomic integration and rearrangement in human cells Open
Although therapeutic genome editing holds great potential to remedy diverse inherited and acquired disorders, targeted installation of medium to large sized genomic modifications in therapeutically relevant cells remains challenging. We ha…
View article: Chemotherapeutic 6-thio-2’-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex
Chemotherapeutic 6-thio-2’-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex Open
Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibit telomere maintenance in cancer cells …
View article: <i>The Binary Cellular Biology of Human Growth</i>: I. Quantifying the Creation and Growth of the Body and its Parts
<i>The Binary Cellular Biology of Human Growth</i>: I. Quantifying the Creation and Growth of the Body and its Parts Open
Assessing and understanding the Growth and Development of animals generally, and of human fetuses specifically, provides essential information for the management of the health of the newborn and its mother. Here we show that a consideratio…
View article: How Our Cells Become Our Selves: The Cellular Phylodynamic Biology of Growth and Development
How Our Cells Become Our Selves: The Cellular Phylodynamic Biology of Growth and Development Open
Our lives begin with 1 cell, then 2, then 4, then the trillion cell adult, comprised of cell lineages, tissues, organs. How does this occur? Examination in numbers of cells, N, Cellular Phylodynamics , revealed two previously unappreciated…
View article: Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages
Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages Open
Germline heterozygous mutations in GATA2 are associated with a syndrome characterized by cytopenias, atypical infections, and increased risk of hematologic malignancies. Here, we generated a zebrafish mutant of gata2b that recapitulated th…
View article: Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors
Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors Open
The establishment of in vitro cultures of zebrafish cancer cells has expanded the potential of zebrafish as a disease model. However, the lack of effective methods for gene delivery and genetic manipulation has limited the experimental app…