William Ngo
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View article: Novel Ocular Thermography Metrics for Dry Eye Screening
Novel Ocular Thermography Metrics for Dry Eye Screening Open
Automated ocular thermography may help to assess ocular dryness in a noninvasive, quantifiable, and real-time manner.
View article: Soybean Lectin Cross-Links Membranes by Binding Sulfatide in a Curvature-Dependent Manner
Soybean Lectin Cross-Links Membranes by Binding Sulfatide in a Curvature-Dependent Manner Open
Soybean (Glycine max) is a key source of plant-based protein, yet its nutritional value is impacted by antinutritional factors, including lectins. Whereas soybean lectin is known to bind N-acetyl-d-galactosamine (GalNAc), its lipid interac…
View article: Efficacy of a new nanoemulsion artificial tear in dry eye disease management: Study protocol for a prospective cohort study
Efficacy of a new nanoemulsion artificial tear in dry eye disease management: Study protocol for a prospective cohort study Open
Background Dry eye disease (DED) is a complex ocular disorder with a significant prevalence worldwide, especially in the Asian population. This study aimed to investigate changes in dry eye symptoms and signs following regular use of a new…
View article: Antiviral activity of contact lens care solutions and rub-and-rinse regimen against adenovirus
Antiviral activity of contact lens care solutions and rub-and-rinse regimen against adenovirus Open
SIGNIFICANCE Although human adenoviruses are the leading cause of acute viral conjunctivitis, there is a lack of data surrounding the efficacy of contact lens care products against these viruses. PURPOSE This study investigates the antivir…
View article: Ocular surface parameters repeatability and agreement —A comparison between Keratograph 5M and IDRA
Ocular surface parameters repeatability and agreement —A comparison between Keratograph 5M and IDRA Open
The NIBUT measurements are not interchangeable between IDRA and K5M, while the TMH was little difference between the two instruments. It is important to exercise caution when using different ocular surface analyzers to minimize errors in c…
View article: A cross-sectional study of optometrists' attitudes towards dry eye disease management in Hong Kong: A web-based survey in Hong Kong
A cross-sectional study of optometrists' attitudes towards dry eye disease management in Hong Kong: A web-based survey in Hong Kong Open
The diagnostic and management strategies of optometrists in Hong Kong were generally consistent with the recommendations of the Dry Eye Workshop II report. However, standardized DED questionnaires and newer diagnostic tools were not common…
View article: Evaluating the in vitro wettability and coefficient of friction of a novel and contemporary reusable silicone hydrogel contact lens materials using an in vitro blink model
Evaluating the in vitro wettability and coefficient of friction of a novel and contemporary reusable silicone hydrogel contact lens materials using an in vitro blink model Open
The results indicate that serafilcon A gradually depletes its reserve of PEO-PBO over 1 week, but this decrease did not significantly change the lens performance in vitro during this time frame.
View article: LipiFlow for the treatment of dry eye disease
LipiFlow for the treatment of dry eye disease Open
LipiFlow performs similarly to other commonly used DED treatments with regard to DED signs and symptoms. The best available evidence was deemed to have a high level of bias, leading to low or very low certainty evidence. Additional researc…
View article: LipiFlow for the treatment of dry eye disease
LipiFlow for the treatment of dry eye disease Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the effectiveness of the LipiFlow Thermal Pulsation System on dry eye signs and symptoms compared to placebo or other commercially availabl…
View article: Tear Film miRNAs and Their Association With Human Dry Eye Disease
Tear Film miRNAs and Their Association With Human Dry Eye Disease Open
This study determined that EVs are present in the tear film and that tear EVs contain miRNAs that may be associated with DED inflammatory pathways.
View article: Eyelid Warming Devices: Safety, Efficacy, and Place in Therapy
Eyelid Warming Devices: Safety, Efficacy, and Place in Therapy Open
Meibomian gland dysfunction (MGD) is characterized by the obstruction and/or inflammation of the meibomian glands that result in decreased and altered meibum secretion. This results in deficiencies in the tear film lipid layer which contri…
View article: The impact of a rub and rinse regimen on removal of human coronaviruses from contemporary contact lens materials
The impact of a rub and rinse regimen on removal of human coronaviruses from contemporary contact lens materials Open
Human coronavirus contamination can be easily removed from CL surfaces. Although CL care products containing hydrogen peroxide and povidone-iodine efficiently removed virus contamination from CL surfaces without the need for a rub and rins…
View article: Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains
Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains Open
Background: Given that reports have suggested SARS-CoV-2 can be transmitted via conjunctiva, the ability of contact lens (CL) care products to reduce the infectiousness of two seasonal human coronavirus (HCoV) (HCoV-229E and HCoV-OC43) sur…
View article: Tear Film miRNAs and Their Association With Human Dry Eye Disease
Tear Film miRNAs and Their Association With Human Dry Eye Disease Open
miRNAs can regulate inflammatory pathways. The purpose of this work was to determine if inflammatory-related tear film miRNAs are associated with extracellular vesicles (EVs) in human non-Sjögren’s Syndrome dry eye disease (DED) participan…
View article: Effects of Temperature and Blinking on Contact Lens Dehydration of Contemporary Soft Lens Materials Using an In Vitro Blink Model
Effects of Temperature and Blinking on Contact Lens Dehydration of Contemporary Soft Lens Materials Using an In Vitro Blink Model Open
This study showed that the novel, heated, in vitro blink model could be used to provide clinical insights into CL dehydration on the eye.
View article: Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease
Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease Open
Several human meibum-derived OAHFAs showed significant associations with PCTF thinning, suggesting that these OAHFAs could be implicated in the mechanism underlying the stabilization and thinning of the PCTF. The tear-film derived OAHFAs w…
View article: Book review: Scleral Lens Issues and Complications: Their Recognition, Etiology, and Management
Book review: Scleral Lens Issues and Complications: Their Recognition, Etiology, and Management Open
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View article: Nanoscale Characteristics of Ocular Lipid Thin Films Using Kelvin Probe Force Microscopy
Nanoscale Characteristics of Ocular Lipid Thin Films Using Kelvin Probe Force Microscopy Open
This study describes the use of KPFM for the study of ocular surface lipids for the first time and outlines possibilities for future studies to be carried out using this concept.