William O. Walker
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View article: Age-Specific Probability of 4 Major Health Outcomes in Children with Spina Bifida
Age-Specific Probability of 4 Major Health Outcomes in Children with Spina Bifida Open
Objective: This study aimed to estimate the age-specific probability of 4 health outcomes in a large registry of individuals with spina bifida (SB). Methods: The association between age and 4 health outcomes was examined in individuals wit…
View article: First-time tethered cord release among adults with myelomeningocele: an analysis of people in the National Spina Bifida Patient Registry
First-time tethered cord release among adults with myelomeningocele: an analysis of people in the National Spina Bifida Patient Registry Open
OBJECTIVE The authors analyzed the National Spina Bifida Patient Registry (NSBPR), a national registry that tracks the outcomes for people with various forms of spinal dysraphism, to determine the ongoing longitudinal risk for tethered cor…
View article: Education and employment as young adults living with spina bifida transition to adulthood in the <scp>USA</scp>: A study of the National Spina Bifida Patient Registry
Education and employment as young adults living with spina bifida transition to adulthood in the <span>USA</span>: A study of the National Spina Bifida Patient Registry Open
Aim To describe the education and employment transition experience of young adults with spina bifida (YASB) and investigate factors associated with employment. Method We queried education and employment data from the US National Spina Bifi…
View article: Tethered spinal cord among individuals with myelomeningocele: an analysis of the National Spina Bifida Patient Registry
Tethered spinal cord among individuals with myelomeningocele: an analysis of the National Spina Bifida Patient Registry Open
OBJECTIVE The aims of this study were to review the National Spina Bifida Patient Registry (NSBPR) data set to study the rates of tethered spinal cord release (TCR) among patients with myelomeningocele and variability between centers, to c…
View article: Prenatal Repair and Physical Functioning Among Children With Myelomeningocele
Prenatal Repair and Physical Functioning Among Children With Myelomeningocele Open
ClinicalTrials.gov Identifier: NCT00060606.
View article: Accelerometer Measurements Indicate That Arm Movements of Children With Cerebral Palsy Do Not Increase After Constraint-Induced Movement Therapy (CIMT)
Accelerometer Measurements Indicate That Arm Movements of Children With Cerebral Palsy Do Not Increase After Constraint-Induced Movement Therapy (CIMT) Open
Importance: Constraint-induced movement therapy (CIMT) is a common treatment for children with unilateral cerebral palsy (CP). Although clinic-based assessments have demonstrated improvements in arm function after CIMT, whether these chang…
View article: Prenatal Repair of Myelomeningocele and School-age Functional Outcomes
Prenatal Repair of Myelomeningocele and School-age Functional Outcomes Open
BACKGROUND AND OBJECTIVES: The Management of Myelomeningocele Study (MOMS), a randomized trial of prenatal versus postnatal repair for myelomeningocele, found that prenatal surgery resulted in reduced hindbrain herniation and need for shun…
View article: Differences in continence rates in individuals with spina bifida based on ethnicity
Differences in continence rates in individuals with spina bifida based on ethnicity Open
After controlling for covariates, Hispanics/Latinos with SB are less likely to report bowel continence. Clinicians are encouraged to consider the risk of negative health disparities for Hispanic patients with SB and work to mitigate this r…
View article: Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia Open
Bi-allelic loss-of-function variants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly understood forms of childhood-onset and complex hereditary spastic paraplegia: SPG47 (AP4B1), SPG50 …
View article: Children with Cerebral Palsy Return to Baseline Community Arm Movement after Constraint Induced Movement Therapy
Children with Cerebral Palsy Return to Baseline Community Arm Movement after Constraint Induced Movement Therapy Open
Importance Constraint Induced Movement Therapy (CIMT) is a common treatment for children with unilateral cerebral palsy (CP). While clinic-based assessments have demonstrated improvements in arm function after CIMT, quantifying if these ch…
View article: Baseline Urinary Imaging in Infants Enrolled in Urologic Management to Preserve Initial Renal Function (UMPIRE) Protocol for Children with Spina Bifida
Baseline Urinary Imaging in Infants Enrolled in Urologic Management to Preserve Initial Renal Function (UMPIRE) Protocol for Children with Spina Bifida Open
PURPOSE: The lifetime risk of renal damage among children with spina bifida (SB) is high, but only limited baseline imaging data are available for this population. We therefore queried a large, prospective cohort of infants with SB to defi…
View article: Genetic epidemiology of neural tube defects
Genetic epidemiology of neural tube defects Open
It has been estimated that 60-70% of neural tube defects (NTDs) have a genetic component, but few causative genes have been identified. The lack of information on genes associated with non-syndromic NTDs in humans is especially notable as …
View article: Pediatrician Use of Down Syndrome Health Supervision Guidelines
Pediatrician Use of Down Syndrome Health Supervision Guidelines Open
Objective: The primary care of children with Down syndrome (DS) requires close attention to specific medical vulnerabilities to maximize quality of life and prevent secondary disability. To help optimize adulthood outcomes for children wit…
View article: Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida
Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida Open
The Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida began accruing patients in 2015. Assessment in the first 5 years will focus on urinary tract infections, renal fun…
View article: The effectiveness of bowel and bladder interventions in children with spina bifida
The effectiveness of bowel and bladder interventions in children with spina bifida Open
Aim Using the World Health Organization International Classification of Functioning, Disability and Health ( ICF ), the aim of this study was to identify effective strategies for managing urinary and bowel complications resulting from spin…