William Perry
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View article: Chronic cannabis use in people with bipolar disorder is associated with comparable decision-making and functional outcome to healthy participants
Chronic cannabis use in people with bipolar disorder is associated with comparable decision-making and functional outcome to healthy participants Open
Impaired decision-making is often seen in people with bipolar disorder (BD), even those undergoing treatment. Targeted therapeutics are therefore needed. People with BD report that cannabis use (CU) attenuates such cognitive and behavioral…
View article: Quantifying exploratory behavior in the human behavioral pattern monitor using automated video tracking
Quantifying exploratory behavior in the human behavioral pattern monitor using automated video tracking Open
Exploration is an essential adaptive function across many species. Distinct exploratory behavior patterns have been observed across several neuropsychiatric conditions, such as schizophrenia and bipolar disorder, leading to the refinement …
View article: A Computational Ethology Approach for Characterizing Behavioral Dynamics in Bipolar Disorder
A Computational Ethology Approach for Characterizing Behavioral Dynamics in Bipolar Disorder Open
Recent technologies for quantifying behavior have revolutionized animal studies in social, cognitive, and pharmacological neurosciences. However, comparable studies in understanding human behavior, especially in psychiatry, are lacking. In…
View article: Co-morbid cannabis use disorder and chronotype are associated with mood symptom onset in people with bipolar disorder
Co-morbid cannabis use disorder and chronotype are associated with mood symptom onset in people with bipolar disorder Open
Comorbid cannabis use disorder (CUD) is disproportionately high in people with bipolar disorder (BD) and has been associated with worsening of BD symptoms. However, many people with BD report regularly using cannabis to ameliorate symptoms…
View article: Improving Early Detection of Cognitive Impairment in Older Adults in Primary Care Clinics: Recommendations From an Interdisciplinary Geriatrics Summit
Improving Early Detection of Cognitive Impairment in Older Adults in Primary Care Clinics: Recommendations From an Interdisciplinary Geriatrics Summit Open
As the population ages, the prevalence of cognitive impairment due to neurodegenerative diseases such as Alzheimer disease (AD) is expected to double in the United States to nearly 14 million over the next 40 years. AD and related dementia…
View article: The Role of Cannabis and The Endocannabinoid System in Sleep Regulation and Cognition: A Review of Human and Animal Studies
The Role of Cannabis and The Endocannabinoid System in Sleep Regulation and Cognition: A Review of Human and Animal Studies Open
The sleep-wake cycle and CRs are both likely modulated by the ECB system, potentially resulting in effects on cognition, however this area is critically understudied.
View article: A Pilot Assessment of the Effects of HIV and Methamphetamine Dependence on Socially Dysregulated Behavior in the Human Behavioral Pattern Monitor
A Pilot Assessment of the Effects of HIV and Methamphetamine Dependence on Socially Dysregulated Behavior in the Human Behavioral Pattern Monitor Open
View article: Distally-based (Reverse) Medial Hemi-flexor Hallucis Brevis Muscle Flap in a Series of High-risk Patients: Retrospective Case Series
Distally-based (Reverse) Medial Hemi-flexor Hallucis Brevis Muscle Flap in a Series of High-risk Patients: Retrospective Case Series Open
Background: The first ray provides an important biomechanical function in ambulation. Loss of this region due to ulceration and pursuant amputation poses significant morbidity to patients. Utilizing the distally based (reverse) medial hemi…
View article: iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression
iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression Open
View article: Chronic methamphetamine exposure exerts few effects on the iTat mouse model of HIV, but blocks Tat expression-induced slowed reward retrieval
Chronic methamphetamine exposure exerts few effects on the iTat mouse model of HIV, but blocks Tat expression-induced slowed reward retrieval Open
View article: The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor
The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor Open
Novelty seeking is a tendency to approach new situations, putatively driven by the brain's catecholaminergic system. It is traditionally measured via self-report, but a laboratory-based paradigm, the human Behavioral Pattern Monitor (hBPM)…
View article: Emergency Department Communication in Persons Living With Dementia and Care Partners: A Scoping Review
Emergency Department Communication in Persons Living With Dementia and Care Partners: A Scoping Review Open
View article: Detecting Cognitive Impairment and Dementia in the Emergency Department: A Scoping Review
Detecting Cognitive Impairment and Dementia in the Emergency Department: A Scoping Review Open
The scoping review and consensus process identified gaps in clinical care that should be prioritized for research efforts to detect cognitive impairment and dementia in the ED setting. These gaps will be addressed as future GEAR 2.0 resear…
View article: Optimal Emergency Department Care Practices for Persons Living With Dementia: A Scoping Review
Optimal Emergency Department Care Practices for Persons Living With Dementia: A Scoping Review Open
View article: Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry Open
View article: Emergency Department Care Transitions for Patients With Cognitive Impairment: A Scoping Review
Emergency Department Care Transitions for Patients With Cognitive Impairment: A Scoping Review Open
This scoping review identified key gaps in ED-to-community care transition interventions delivered to older adults with cognitive impairment. Combined with a stakeholder assessment and prioritization, it identified relevant patient-centere…
View article: The Relationships between HIV-1 Infection, History of Methamphetamine Use Disorder, and Soluble Biomarkers in Blood and Cerebrospinal Fluid
The Relationships between HIV-1 Infection, History of Methamphetamine Use Disorder, and Soluble Biomarkers in Blood and Cerebrospinal Fluid Open
Methamphetamine (METH) use disorder is highly prevalent among people with HIV (PWH) and is a significant public health problem. HIV and METH use are each associated with immune system dysfunction; however, the combined effects on the immun…
View article: Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice
Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice Open
View article: Prior Chronic Methamphetamine Treatment and Gp120 Expression Additively Reduce PPI in Aged Male But Not Female Mice
Prior Chronic Methamphetamine Treatment and Gp120 Expression Additively Reduce PPI in Aged Male But Not Female Mice Open
View article: The relationship between cannabis use and cognition in people with bipolar disorder: A systematic scoping review
The relationship between cannabis use and cognition in people with bipolar disorder: A systematic scoping review Open
View article: Spatially Targeted Proteomics of the Host–Pathogen Interface during Staphylococcal Abscess Formation
Spatially Targeted Proteomics of the Host–Pathogen Interface during Staphylococcal Abscess Formation Open
Staphylococcus aureus is a common cause of invasive and life-threatening infections that are often multidrug resistant. To develop novel treatment approaches, a detailed understanding of the complex host-pathogen interactions during…
View article: The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review
The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review Open
Background Older adults (≥50 years) represent the fastest-growing population of people who use cannabis, potentially due to the increasing promotion of cannabis as medicine by dispensaries and cannabis websites. Given healthy aging and can…
View article: Both HIV and Tat expression decrease prepulse inhibition with further impairment by methamphetamine
Both HIV and Tat expression decrease prepulse inhibition with further impairment by methamphetamine Open
View article: Spatially-targeted proteomics of the host-pathogen interface during staphylococcal abscess formation
Spatially-targeted proteomics of the host-pathogen interface during staphylococcal abscess formation Open
Staphylococcus aureus is a common cause of invasive and life-threatening infections that are often multi-drug resistant. To develop novel treatment approaches, a detailed understanding of the complex host-pathogen interactions during infec…
View article: Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence
Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence Open
View article: Both HIV and Tat Expression Decrease Prepulse Inhibition with Further Impairment by Methamphetamine
Both HIV and Tat Expression Decrease Prepulse Inhibition with Further Impairment by Methamphetamine Open
HIV infection and methamphetamine (METH) use are highly comorbid and represent a significant public health problem. Both conditions are known to negatively impact a variety of brain functions. One brain function that may be affected by HIV…
View article: Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence
Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence Open
Background Human immunodeficiency virus (HIV)-associated neurocognitive disorders persist in the era of antiretroviral therapy (ART). One factor that is elevated among persons with HIV (PWH) and independently associated with neurocognitive…
View article: The effects of cannabis use on cognitive function in healthy aging: A systematic scoping review
The effects of cannabis use on cognitive function in healthy aging: A systematic scoping review Open
Middle-to-older-aged adults (>50 years) represent the fastest-growing cannabis-using population. Given aging and cannabis use are associated with cognitive decline, it is important to establish the effects of cannabis on cognitive function…
View article: The Relationship between Cannabis Use and Cognition in People with Bipolar Disorder: A Systematic Scoping Review
The Relationship between Cannabis Use and Cognition in People with Bipolar Disorder: A Systematic Scoping Review Open
Bipolar disorder (BD) and cannabis use are highly comorbid and are each associated with cognitive impairment. It is therefore important to understand the relationship between cannabis use and cognition in people with BD, as cannabis use in…
View article: Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis
Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis Open
Compromising the integrity of the bacterial cell barrier is a common action of antimicrobials. Targocil is an antimicrobial that is active against the bacterial envelope. We hypothesized that Bacillus anthracis , a potential weapon of biot…