William Planer
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View article: Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I
Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I Open
β2-Glycoprotein I (β2-GPI) is an abundant plasma glycoprotein with unknown physiological function and is currently recognized as the main target of antiphospholipid Abs responsible for complement activation and vascular thrombosis in patie…
View article: The J-elongated conformation of β2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome
The J-elongated conformation of β2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome Open
β2-Glycoprotein I (β2GPI) is an abundant plasma protein displaying phospholipid-binding properties. Because it binds phospholipids, it is a target of antiphospholipid antibodies (aPLs) in antiphospholipid syndrome (APS), a life-threatening…
View article: X-ray and solution structures of human beta-2 glycoprotein I reveal a new mechanism of autoantibody recognition
X-ray and solution structures of human beta-2 glycoprotein I reveal a new mechanism of autoantibody recognition Open
Venous and arterial thromboses in patients suffering from the autoimmune disorder Antiphospholipid Syndrome (APS) are caused by the presence of antiphospholipid antibodies (aPL). Emerging evidence indicates that autoantibodies targeting th…
View article: Discovery and characterization of 2 novel subpopulations of aPS/PT antibodies in patients at high risk of thrombosis
Discovery and characterization of 2 novel subpopulations of aPS/PT antibodies in patients at high risk of thrombosis Open
Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies are often detected in patients with antiphospholipid syndrome (APS), but how aPS/PT engage prothrombin at the molecular level remains unknown. Here, the antigenic determinants of immu…
View article: Structure of Coagulation Factor II: Molecular Mechanism of Thrombin Generation and Development of Next-Generation Anticoagulants
Structure of Coagulation Factor II: Molecular Mechanism of Thrombin Generation and Development of Next-Generation Anticoagulants Open
Coagulation factor II, or prothrombin, is a multi-domain glycoprotein that is essential for life and a key target of anticoagulant therapy. In plasma, prothrombin circulates in two forms at equilibrium, "closed" (~80%) and "open" (~20%), b…