William Ricketts
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View article: Multi-centre discovery and validation study evaluating breath biomarkers for the diagnosis of lung cancer – the LuCID study
Multi-centre discovery and validation study evaluating breath biomarkers for the diagnosis of lung cancer – the LuCID study Open
Background Volatile Organic Compound (VOC) research for lung cancer detection has faced study design and analytical methodology challenges limiting translation into clinical practice. We evaluated the diagnostic value of breath biomarkers …
View article: Impact of Low-Dose Computed Tomography Findings on Cigarette Smoking Cessation Among High-Risk Adults Participating in Lung Cancer Screening
Impact of Low-Dose Computed Tomography Findings on Cigarette Smoking Cessation Among High-Risk Adults Participating in Lung Cancer Screening Open
Introduction Integrating effective smoking cessation strategies for individuals undergoing lung cancer screening stands to significantly increase the impact of lung screening programmes. We assessed the impact of low-dose computed tomograp…
View article: Impact of a hybrid, short-term prehabilitation on patient-reported outcomes in patients undergoing lung resection for non-small cell lung cancer
Impact of a hybrid, short-term prehabilitation on patient-reported outcomes in patients undergoing lung resection for non-small cell lung cancer Open
OBJECTIVES We examined the impact of short-term, multimodal prehabilitation on perioperative functional and patient-reported outcomes (PROs) in patients undergoing surgical resection for non-small cell lung cancer (NSCLC). METHODS This is …
View article: Development and implementation of a digital health intervention in routine care for long COVID patients: a comprehensive synopsis
Development and implementation of a digital health intervention in routine care for long COVID patients: a comprehensive synopsis Open
Background By July 2020, large numbers of post-COVID patients were experiencing symptoms for weeks or months, but traditional National Health Service models of rehabilitation service delivery could not meet demand. Objectives Design and de…
View article: Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study
Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study Open
GRAIL.
View article: Experiences of user-centred design with agile development for clinically supported self-management of Long Covid
Experiences of user-centred design with agile development for clinically supported self-management of Long Covid Open
The aim of the study reported here was to reflect and report on lessons learned from adapting HCI methods to fit into an agile development process delivering a digital intervention for people managing Long Covid. During the project, we mai…
View article: Using normalisation process theory to evaluate the implementation of a digital health intervention in community and secondary care long COVID clinics
Using normalisation process theory to evaluate the implementation of a digital health intervention in community and secondary care long COVID clinics Open
Objectives The potential and expected benefits of digital health interventions (DHI) have long been discussed, yet substantial challenges are associated with deploying DHI at scale. Insights are presented concerning the implementation of a…
View article: Understanding the impact of distance and disadvantage on lung cancer care and outcomes: a study protocol
Understanding the impact of distance and disadvantage on lung cancer care and outcomes: a study protocol Open
Background Lung cancer is the third most common cancer in the UK and the leading cause of cancer mortality globally. NHS England guidance for optimum lung cancer care recommends management and treatment by a specialist team, with experts c…
View article: International consensus is needed on a core outcome set to advance the evidence of best practice in cancer prehabilitation services and research
International consensus is needed on a core outcome set to advance the evidence of best practice in cancer prehabilitation services and research Open
Prehabilitation aims to optimise patients' physical and psychological status before treatment. The types of outcomes measured to assess the impact of prehabilitation interventions vary across clinical research and service evaluation, limit…
View article: Automated Derivation of Diagnostic Criteria for Lung Cancer using Natural Language Processing on Electronic Health Records: A pilot study
Automated Derivation of Diagnostic Criteria for Lung Cancer using Natural Language Processing on Electronic Health Records: A pilot study Open
Background The digitisation of healthcare records has generated vast amounts of unstructured data, presenting opportunities for improvements in disease diagnosis when clinical coding falls short, such as in the recording of patient symptom…
View article: Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study
Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study Open
Objectives To describe self-reported characteristics and symptoms of treatment-seeking patients with post-COVID-19 syndrome (PCS). To assess the impact of symptoms on health-related quality of life (HRQoL) and patients’ ability to work and…
View article: Supplementary Table 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Table 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 50K, Primary investigation series. Cox's proportional hazard regression model used to estimate the prognostic value of pStathmin(S38) in endometrial carcinomas, in relation to histopathologic variables and Stathmin.
View article: Supplementary Figure 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Figure 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 49K, pStathmin(S38) identifies patients with different prognosis in subgroups of patients with expected good survival.
View article: Supplementary Figure 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Figure 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 49K, pStathmin(S38) identifies patients with different prognosis in subgroups of patients with expected good survival.
View article: Data from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Data from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
Purpose: High Stathmin expression has recently been associated with clinical progress in endometrial cancers. Stathmin protein activity is modulated by phosphorylation, and the Serine38 site is one of four Stathmin phospho-sites. The prese…
View article: Supplementary Figure Legend from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Figure Legend from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 52K
View article: Supplementary Figure 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Figure 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 40K, Unsupervised hierarchical clustering of gene expression data from endometrial carcinoma. The pStathmin(S38) high cases are significantly overrepresented in two of the clusters with aggressive tumors.
View article: Supplementary Table 3 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Table 3 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 84K, Gene Set Enrichment Analysis (www.broadinstitute.org/gsea/msigdb). Gene sets (GO categories, computational gene sets and curated gene sets) within FDR<10% related to cell cycle/cell proliferation and being enriched in tumor…
View article: Supplementary Table 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Table 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 50K, Validations series. Cox's proportional hazard regression model used to estimate the prognostic value of pStathmin(S38) in endometrial carcinomas, in relation to histopathologic variables and Stathmin.
View article: Supplementary Figure 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Figure 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 40K, Unsupervised hierarchical clustering of gene expression data from endometrial carcinoma. The pStathmin(S38) high cases are significantly overrepresented in two of the clusters with aggressive tumors.
View article: Supplementary Figure Legend from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Figure Legend from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 52K
View article: Supplementary Table 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Table 2 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 50K, Validations series. Cox's proportional hazard regression model used to estimate the prognostic value of pStathmin(S38) in endometrial carcinomas, in relation to histopathologic variables and Stathmin.
View article: Data from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Data from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
Purpose: High Stathmin expression has recently been associated with clinical progress in endometrial cancers. Stathmin protein activity is modulated by phosphorylation, and the Serine38 site is one of four Stathmin phospho-sites. The prese…
View article: Supplementary Table 3 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Table 3 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 84K, Gene Set Enrichment Analysis (www.broadinstitute.org/gsea/msigdb). Gene sets (GO categories, computational gene sets and curated gene sets) within FDR<10% related to cell cycle/cell proliferation and being enriched in tumor…
View article: Supplementary Table 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition
Supplementary Table 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition Open
PDF file - 50K, Primary investigation series. Cox's proportional hazard regression model used to estimate the prognostic value of pStathmin(S38) in endometrial carcinomas, in relation to histopathologic variables and Stathmin.
View article: Integration of respiratory physiology and clinical reasoning in the early years of a medical curriculum: engaging with students in a large classroom setting
Integration of respiratory physiology and clinical reasoning in the early years of a medical curriculum: engaging with students in a large classroom setting Open
The development of teaching methods that support integrated learning and build student confidence is a priority. An audience response system was used to engage early year medical students in large classes in preparation for teaching within…
View article: Real-world use of the Breathing Pattern Assessment Tool in assessment of breathlessness post-COVID-19
Real-world use of the Breathing Pattern Assessment Tool in assessment of breathlessness post-COVID-19 Open
BPAT has high sensitivity and moderate specificity for BPD in patients with long COVID. This would support its use as a screening test in clinic, and as a diagnostic tool for large cohort studies.