William N. Setzer
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View article: Seasonal Variation in Essential Oil Composition and Yield of Rhus aromatica Aiton (Fragrant Sumac) and a Preliminary Comparison with Rhus trilobata
Seasonal Variation in Essential Oil Composition and Yield of Rhus aromatica Aiton (Fragrant Sumac) and a Preliminary Comparison with Rhus trilobata Open
Rhus is a genus of shrubs that produces strong aromatic essential oils. These oils have numerous applications, including treating urinary infections, flavoring food, and alleviating gastrointestinal ailments. We conducted an experiment to …
View article: Protozoan Neglected Tropical Diseases (NTDs) Target Inhibition of Alkaloids from Croton linearis Jacq Leaves: A Molecular Docking and ADMET Approach
Protozoan Neglected Tropical Diseases (NTDs) Target Inhibition of Alkaloids from Croton linearis Jacq Leaves: A Molecular Docking and ADMET Approach Open
Background/Objectives: Neglected tropical diseases (NTDs) caused by protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, Leishmania spp., and Plasmodium falciparum remain a global health challenge due to limited therapies and…
View article: Sandalwood Sesquiterpene (Z)-α-Santalol Exhibits In Vivo Efficacy Against Madurella mycetomatis in Galleria mellonella Larvae
Sandalwood Sesquiterpene (Z)-α-Santalol Exhibits In Vivo Efficacy Against Madurella mycetomatis in Galleria mellonella Larvae Open
In continuation of our recent report on the in vitro activity of sandalwood essential oils and their major components, the sesquiterpenes (Z)-α- and -β-santalols, against the pathogenic fungus Madurella mycetomatis, causative agent of the …
View article: Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy
Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy Open
The epidermal growth factor receptor (EGFR/HER1) and human epidermal growth factor receptor 2 (HER2) are key members of the ErbB tyrosine kinase receptor family, playing central roles in the pathogenesis of various cancers, including breas…
View article: Insecticidal Efficacy of Satureja hortensis L. and Satureja khuzistanica Jamzad Essential Oils Against Callosobruchus maculatus (F.)
Insecticidal Efficacy of Satureja hortensis L. and Satureja khuzistanica Jamzad Essential Oils Against Callosobruchus maculatus (F.) Open
The cowpea weevil, Callosobruchus maculatus (F.), stands out as one of the most destructive field-to-storage pests of leguminous crops. This study investigates the potential of essential oils derived from two Satureja species, Satureja hor…
View article: Enantioselective gas chromatographic analysis of Cupressaceae foliar essential oils: Callitropsis nootkatensis, Calocedrus decurrens, Sequoia sempervirens, and Thuja plicata
Enantioselective gas chromatographic analysis of Cupressaceae foliar essential oils: Callitropsis nootkatensis, Calocedrus decurrens, Sequoia sempervirens, and Thuja plicata Open
View article: Optimization of Supplemental LED Spectral Quality and Light Dose for Enhancing Biomass and Essential Oil Yield of Ocimum gratissimum L. Under Net House Condition
Optimization of Supplemental LED Spectral Quality and Light Dose for Enhancing Biomass and Essential Oil Yield of Ocimum gratissimum L. Under Net House Condition Open
This study investigated optimal supplemental multispectral light-emitting diode (LED) conditions for the growth and essential oil accumulation of Ocimum gratissimum L. (OG) cultivated in a net house over 15 weeks. We hypothesized that supp…
View article: Chemical Composition and Biological Activities of Chromolaena odorata (L.) R.M.King & H.Rob. Essential Oils from Central Vietnam
Chemical Composition and Biological Activities of Chromolaena odorata (L.) R.M.King & H.Rob. Essential Oils from Central Vietnam Open
The chemical composition of leaf essential oil of the harmful invasive species Chromolaena odorata collected in Vietnam was analyzed by GC/MS and chiral GC. All three essential oil samples (O1, O2 and O3) in this study fell into chemotype …
View article: Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies
Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies Open
Nausea and vomiting are common and distressing responses to toxins, chemotherapy, and gastrointestinal disturbances. Although antiemetic medications are available, their adverse effects make safer substitutes necessary. In our study, Thymo…
View article: Seasonal Variation in Essential Oil Composition and Bioactivity of Three Ocimum Species from Nepal
Seasonal Variation in Essential Oil Composition and Bioactivity of Three Ocimum Species from Nepal Open
The plants from the Ocimum genus, belonging to the Labiatae family, serve as important bioresources of essential oils (EOs) rich in biologically active secondary metabolites, widely used in medicine, food, and cosmetics. This study explore…
View article: The sesquiterpene-rich composition of the leaf essential oil of Croton lobatus L. growing in north-central Nigeria
The sesquiterpene-rich composition of the leaf essential oil of Croton lobatus L. growing in north-central Nigeria Open
View article: Chemical Characterization, Antimicrobial, Antioxidant and Cytotoxic Potential of Essential Oils from Perilla frutescens L. found in Nepal
Chemical Characterization, Antimicrobial, Antioxidant and Cytotoxic Potential of Essential Oils from Perilla frutescens L. found in Nepal Open
Perilla is widely valued for its culinary, aromatic, and medicinal uses. This study was conducted to characterize the chemical components, enantiomeric distribution, and to explore the antimicrobial, antioxidant, and cytotoxic potential of…
View article: Optimization of Supplemental LED Spectral Quality and Light Dose for Enhancing Biomass and Essential Oil Yield of <em>Ocimum gratissimum</em> L. under Net House Condition
Optimization of Supplemental LED Spectral Quality and Light Dose for Enhancing Biomass and Essential Oil Yield of <em>Ocimum gratissimum</em> L. under Net House Condition Open
This study investigated the impact of supplemental multispectral light-emitting diode (LED) lighting at night on the growth and essential oil production of Ocimum gratissimum L. (OG) cultivated in a net house over 15 weeks. Nine lighting t…
View article: Toxicity and Detoxification Enzyme Inhibition in the Two-Spotted Spider Mite (Tetranychus urticae Koch) by Artemisia annua L. Essential Oil and Its Major Monoterpenoids
Toxicity and Detoxification Enzyme Inhibition in the Two-Spotted Spider Mite (Tetranychus urticae Koch) by Artemisia annua L. Essential Oil and Its Major Monoterpenoids Open
The two-spotted spider mite, Tetranychus urticae, is one of the polyphagous pests of several crops and forestry, resistant to numerous conventional chemicals. Due to the negative side effects of harmful chemical pesticides, such as environ…
View article: Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent
Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent Open
Fucoidan is a naturally occurring, sulfated fucose‐based polymer found in many types of brown algae. Fucoidan has recently attracted interest in the field of oncology due to its biological and pharmacological features, such as antitumor, a…
View article: Correction: Abd Algaffar et al. Sandalwood Oils of Different Origins Are Active In Vitro against Madurella mycetomatis, the Major Fungal Pathogen Responsible for Eumycetoma. Molecules 2024, 29, 1846
Correction: Abd Algaffar et al. Sandalwood Oils of Different Origins Are Active In Vitro against Madurella mycetomatis, the Major Fungal Pathogen Responsible for Eumycetoma. Molecules 2024, 29, 1846 Open
In the original publication [...]
View article: Vetiver, Vetiveria zizanioides (L.) Nash: Biotechnology, Biorefineries, and the Production of Volatile Phytochemicals
Vetiver, Vetiveria zizanioides (L.) Nash: Biotechnology, Biorefineries, and the Production of Volatile Phytochemicals Open
This current review study covers the applications of vetiver essential oil (VEO) in phytoremediation, emphasizing its remedial capabilities in the cleaning of environmental pollutants like pesticides, fertilizers, fungicides, herbicides, h…
View article: Formulation and evaluation of herbal antioxidant cream from selected plantscollected from the Nepalese Himalayan region
Formulation and evaluation of herbal antioxidant cream from selected plantscollected from the Nepalese Himalayan region Open
Due to the strong tyrosinase inhibition and antioxidant effects, green tea and licorice are valuable herbal sources in the cosmetic industry for their beneficial effects on the skin. However, data on the addition of essential oils, green t…
View article: Chemical Compounds and Antimicrobial Assessment of the Essential oil from <i>Lippia micromera</i> Harvested in Cuba
Chemical Compounds and Antimicrobial Assessment of the Essential oil from <i>Lippia micromera</i> Harvested in Cuba Open
Background/Objective: Anti-infective agents derived from plants have become important and favorable resources against diseases. In particular, essential oils have emerged as promising antimicrobial natural alternatives. The objective of th…
View article: Harnessing <i>Jasminum</i> Bioactive Compounds: Updated Insights for Therapeutic and Food Preservation Innovations
Harnessing <i>Jasminum</i> Bioactive Compounds: Updated Insights for Therapeutic and Food Preservation Innovations Open
The Jasminum genus, renowned for its aromatic flowers, has been used in traditional medicine across various cultures for its therapeutic properties. Recently, scientific interest has focused on the bioactive compounds present in Jasminum s…
View article: Chemical Composition and Enantiomeric Distribution of the Essential oil of <i>Larix occidentalis</i> Nutt
Chemical Composition and Enantiomeric Distribution of the Essential oil of <i>Larix occidentalis</i> Nutt Open
Background/Objective: Larix occidentalis (Pinaceae) is a tree native to the mountains of northwestern United States and southwestern Canada. Indigenous peoples used this tree as part of their traditional medicine to treat various ailments,…
View article: Chemical Composition and Larvicidal Activity of the Essential oil of <i>Alpinia breviligulata</i> (Gagnep.) Gagnep. Against Two Species of <i>Aedes</i> Mosquitoes
Chemical Composition and Larvicidal Activity of the Essential oil of <i>Alpinia breviligulata</i> (Gagnep.) Gagnep. Against Two Species of <i>Aedes</i> Mosquitoes Open
Background: Essential oils are promising candidates for the development of next-generation biopesticides, offering a sustainable alternative to traditional synthetic pesticides. Methods: In this study, essential oils from various parts of …
View article: The volatile components of Eriogonum ovalifolium var. depressum from southeastern Oregon
The volatile components of Eriogonum ovalifolium var. depressum from southeastern Oregon Open
View article: Lomatium Species of the Intermountain Western United States: A Chemotaxonomic Investigation Based on Essential Oil Compositions
Lomatium Species of the Intermountain Western United States: A Chemotaxonomic Investigation Based on Essential Oil Compositions Open
Lomatium is a genus of 98 species, widely distributed in western North America. This work presents a chemometric analysis of the essential oils of seven species of Lomatium (L. anomalum, L. dissectum var. dissectum, L. multifidum, L. nudic…
View article: Leaf Essential Oil Compositions and Enantiomeric Distributions of Monoterpenoids in Pinus Species: Pinus albicaulis, Pinus flexilis, Pinus lambertiana, Pinus monticola, and Pinus sabiniana
Leaf Essential Oil Compositions and Enantiomeric Distributions of Monoterpenoids in Pinus Species: Pinus albicaulis, Pinus flexilis, Pinus lambertiana, Pinus monticola, and Pinus sabiniana Open
Members of the Pinus genus are well known for their medicinal properties, which can be attributed to their essential oils. In this work, we have examined the leaf essential oils of five understudied Pinus species collected from various loc…
View article: The cytotoxic activity of extracts from the Camellia luongii Tran & Le
The cytotoxic activity of extracts from the Camellia luongii Tran & Le Open
View article: Activity of Cochleates-Like Formulations of Artemisinin Against Leishmania Amazonensis
Activity of Cochleates-Like Formulations of Artemisinin Against Leishmania Amazonensis Open
View article: Chemical composition of the foliar essential oil of Tsuga mertensiana (Bong.) Carrière
Chemical composition of the foliar essential oil of Tsuga mertensiana (Bong.) Carrière Open
View article: The Quantitation of EPA and DHA in Fish Oil Dietary Supplements Sold in the United States
The Quantitation of EPA and DHA in Fish Oil Dietary Supplements Sold in the United States Open
The dietary supplement industry is expanding, but it still remains far less regulated than the pharmaceutical industry, resulting in inconsistent quality control. Limited research has been performed in the U.S., particularly regarding the …
View article: Insight into Chemical Composition and Anti-inflammatory Activities of Essential Oil from Flowers, Leaves and Vine Stems of Cissampelopsis volubilis Miq.
Insight into Chemical Composition and Anti-inflammatory Activities of Essential Oil from Flowers, Leaves and Vine Stems of Cissampelopsis volubilis Miq. Open