William Sterlacci
YOU?
Author Swipe
View article: Mutational analysis differentiating sporadic carcinomas from colitis-associated colorectal carcinomas
Mutational analysis differentiating sporadic carcinomas from colitis-associated colorectal carcinomas Open
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that is associated with increased risk of developing colitis-associated carcinoma (CAC). The genetic profile of CACs is fairly similar to the sporadic colorec…
View article: Histological Presentation of EoE: simply a magic number ?
Histological Presentation of EoE: simply a magic number ? Open
Background: Eosinophilic esophagitis (EOE) is an increasing condition in industrialized countries. The etiology is still somewhat unclear. It was thought that it can be part of eosinophilic gastroenteritis but nowadays seen as separate ent…
View article: RNF43 is a gatekeeper for colitis-associated cancer
RNF43 is a gatekeeper for colitis-associated cancer Open
SUMMARY Somatic mutations in the tumor suppressor Ring finger protein 43 ( RNF43 ) were frequently found in colitis-associated cancer (CAC) and related to the duration of chronic inflammation, but their significance in inflammation and inf…
View article: Methylation Analysis of Colitis-Associated Colorectal Carcinomas
Methylation Analysis of Colitis-Associated Colorectal Carcinomas Open
The results show that these three methylation sites are promising markers in the diagnosis of CAC vs sCRC. Nevertheless, the diagnosis should always be made in conjunction with histomorphological analyses.
View article: Histopathological Assessment of the Endoscopic Resection Specimen
Histopathological Assessment of the Endoscopic Resection Specimen Open
Background: Endoscopic resection for early neoplastic lesions of the gastrointestinal tract is nowadays the accepted and feasible method also in non-tertiary reference centers. The main clinical advantage is the preserved quality of life c…
View article: Detection of Fusobacterium nucleatum in Patients with Colitis-Associated Colorectal Cancer
Detection of Fusobacterium nucleatum in Patients with Colitis-Associated Colorectal Cancer Open
Fusobacterium nucleatum is supposed to play a critical role in the development of colorectal cancer. The species has also been associated with ulcerative colitis (UC) that can progress into colorectal cancer, however, the involvement of ba…
View article: Rapid Detection of Quinolone Resistance Mutations in gyrA of Helicobacter pylori by Real-Time PCR
Rapid Detection of Quinolone Resistance Mutations in gyrA of Helicobacter pylori by Real-Time PCR Open
The treatment of infections by the gastric pathogen Helicobacter pylori (H. pylori) has become more difficult due to increased rates of resistances against various antibiotics. Typically, atriple therapy, employing a combination of at leas…
View article: MET Amplification in Non-Small Cell Lung Cancer (NSCLC)—A Consecutive Evaluation Using Next-Generation Sequencing (NGS) in a Real-World Setting
MET Amplification in Non-Small Cell Lung Cancer (NSCLC)—A Consecutive Evaluation Using Next-Generation Sequencing (NGS) in a Real-World Setting Open
In non-small cell lung cancer (NSCLC), approximately 1–3% of cases harbor an increased gene copy number (GCN) of the MET gene. This alteration can be due to de novo amplification of the MET gene or can represent a secondary resistance mech…
View article: Gynecological Neoplasms are the Major Cause for Malignant Effusions
Gynecological Neoplasms are the Major Cause for Malignant Effusions Open
Background: Malignant effusions occur frequently in gynecologic neoplasms and may worsen the prognosis for these patients. Therefore a more detailed analysis for the different cavities is necessary to describe the association between the v…
View article: Helicobacter Infection and Gastric Adenoma
Helicobacter Infection and Gastric Adenoma Open
Background: We aimed to provide insight into the actual frequencies of gastric adenoma types and their association with gastritis status and associated mucosal changes with a focus on Helicobacter infection and the operative link on gastri…
View article: Rapid detection of SARS-CoV-2 infection by multicapillary column coupled ion mobility spectrometry (MCC-IMS) of breath. A proof of concept study
Rapid detection of SARS-CoV-2 infection by multicapillary column coupled ion mobility spectrometry (MCC-IMS) of breath. A proof of concept study Open
There is an urgent need for screening of patients having a communicable viral disease to cut infection chains. We could recently demonstrate that MCC-IMS of breath is able to identify Influenza-A infected patients. With decreasing Influenz…
View article: Rapid detection of SARS-CoV-2 infection by multicapillary column coupled ion mobility spectrometry (MCC-IMS) of breath. A proof of concept study
Rapid detection of SARS-CoV-2 infection by multicapillary column coupled ion mobility spectrometry (MCC-IMS) of breath. A proof of concept study Open
There is an urgent need for screening of patients having a communicable viral disease to cut infection chains. We could recently demonstrate that MCC-IMS of breath is able to identify Influenza-A infected patients. With decreasing Influenz…
View article: Rapid non-invasive detection of Influenza-A-infection by multicapillary column coupled ion mobility spectrometry
Rapid non-invasive detection of Influenza-A-infection by multicapillary column coupled ion mobility spectrometry Open
Infectious pathogens are a global issue. Global air travelling offers an easy and fast opportunity not only for people but also for infectious diseases to spread around the world within a few days. Also, large public events facilitate incr…
View article: Diagnostic and prognostic impact of mucin 1–6 expression in non-small cell lung cancer
Diagnostic and prognostic impact of mucin 1–6 expression in non-small cell lung cancer Open
MUCs were associated with histologic subtypes, tumor differentiation and members of the epidermal growth factor receptor signaling pathway, although they were not found to be significant for prognosis. Expression of MUC1 correlated with ce…
View article: Erratum: Leukotriene Receptor Blockade as a Life-Saving Treatment in Severe Bronchopulmonary Dysplasia
Erratum: Leukotriene Receptor Blockade as a Life-Saving Treatment in Severe Bronchopulmonary Dysplasia Open
Background: Bronchopulmonary dysplasia (BPD) is a major cause of mortality and morbidity in infants with an extremely low birth weight. Because there is no effective therapy, the mortality of this condition in severely affected patients is…
View article: Digital single-operator pancreatoscopy for evaluation of intraductal papillary mucinous neoplasm
Digital single-operator pancreatoscopy for evaluation of intraductal papillary mucinous neoplasm Open
Although main-duct intraductal papillary mucinous neoplasm (IPMN) and mixed-type IPMN are frequently associated with malignancy and usually lead to surgery, branch-duct IPMNs biologically behave in a more indolent manner. Prediction of mal…
View article: 22-gauge core <i>vs</i> 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses
22-gauge core <i>vs</i> 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses Open
Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle.
View article: Expression of PD-L1 Identifies a Subgroup of More Aggressive Non-Small Cell Carcinomas of the Lung
Expression of PD-L1 Identifies a Subgroup of More Aggressive Non-Small Cell Carcinomas of the Lung Open
Objectives: In light of various trials showing impressive response rates when treating non-small cell lung cancer (NSCLC) patients with anti PD-1/PD-L1 antibodies, the currently equivocal role of PD-L1 expression in NSCLC is in need of fur…
View article: Revised World Health Organization Classification of Lung Tumours. Important Changes and Implications
Revised World Health Organization Classification of Lung Tumours. Important Changes and Implications Open
The World Health Organization (WHO) has recently published the newest edition of their WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart [1]. The previous edition was published in 2004, which is a relatively long time spa…