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View article: Depression is both a risk factor for and outcome from traumatic brain injury in UK Biobank (N=502,356)
Depression is both a risk factor for and outcome from traumatic brain injury in UK Biobank (N=502,356) Open
Background: Traumatic brain injury (TBI) is a known risk factor for dementia and earlier mortality, but its association with psychological health is less well-characterized. We tested for associations between TBI and depression, each ascer…
View article: Depression is both a risk factor for and outcome from traumatic brain injury in UK Biobank (N=502,356)
Depression is both a risk factor for and outcome from traumatic brain injury in UK Biobank (N=502,356) Open
Background: Traumatic brain injury (TBI) is a known risk factor for dementia and earlier mortality, but its association with psychological health is less well-characterized. We tested for associations between TBI and depression, each ascer…
View article: Genetic risk for Alzheimer’s disease, and differential trajectories in circulating blood biomarkers in UK Biobank (n=17,817)
Genetic risk for Alzheimer’s disease, and differential trajectories in circulating blood biomarkers in UK Biobank (n=17,817) Open
Understanding pathways from genetic variation to cognitive impairment is critical for dementia prevention, risk stratification and the development of treatments. While genetic risk factors for dementia are known to associate with cross-sec…
View article: Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma
Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma Open
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive…
View article: Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340)
Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340) Open
It is unclear to what extent genetic risk offsets the protective effects of better premorbid cognitive health on the risk of Alzheimer’s disease (AD). We tested for associations between measures of premorbid cognitive health, apolipoprotei…
View article: Intimate partner violence, traumatic brain injury and long-term mental health outcomes in midlife: the Drake IPV study
Intimate partner violence, traumatic brain injury and long-term mental health outcomes in midlife: the Drake IPV study Open
Background Approximately 30% of women experience intimate partner violence (IPV) in their lifetime, often with traumatic brain injury (TBI) exposure. Nevertheless, there has been limited research exploring lifelong brain health outcomes fo…
View article: Health and Lifestyle Factors and Dementia Risk Among Former Professional Soccer Players
Health and Lifestyle Factors and Dementia Risk Among Former Professional Soccer Players Open
Importance Elite-level contact sport participation is associated with increased dementia risk, which may be attributable to sport-related traumatic brain injury and repetitive head impact exposure. However, the contribution of wider, poten…
View article: Chronic traumatic encephalopathy neuropathologic change is associated with higher stage limbic‐predominant age‐related TDP‐43 encephalopathy
Chronic traumatic encephalopathy neuropathologic change is associated with higher stage limbic‐predominant age‐related TDP‐43 encephalopathy Open
Background Traumatic brain injury (TBI) is recognized as one major, potentially modifiable risk factor for neurodegenerative disease (NDD). Autopsy studies describe a range of neuropathologies in a proportion of individuals surviving late …
View article: Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N=252,340)
Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N=252,340) Open
Background: It is unclear to what extent genetic risk offsets the protective effects of better premorbid cognitive health, on risk of Alzheimer’s disease (AD). To address this, we tested for associations between measures of premorbid cogni…
View article: Pediatric Traumatic Brain Injury and Microvascular Blood-Brain Barrier Pathology
Pediatric Traumatic Brain Injury and Microvascular Blood-Brain Barrier Pathology Open
Importance Pediatric traumatic brain injury (TBI) is a major cause of morbidity and mortality, with an increased risk of catastrophic outcome compared with adult TBI, including diffuse brain swelling and so-called second impact syndrome. N…
View article: Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury
Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury Open
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translat…
View article: Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study
Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study Open
Importance Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated chang…
View article: The impact of NRC guidance on concentration averaging on low level waste sealed sources disposal
The impact of NRC guidance on concentration averaging on low level waste sealed sources disposal Open
View article: Contrasting Characteristics and Outcomes of Sports-Related and Non–Sports-Related Traumatic Brain Injury
Contrasting Characteristics and Outcomes of Sports-Related and Non–Sports-Related Traumatic Brain Injury Open
Importance Exposure to traumatic brain injury (TBI) has raised widespread concern over participation in sports, particularly over possible long-term consequences. However, little is known about the outcomes of individuals presenting to hos…
View article: The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia
The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia Open
PREVENT is a multi-centre prospective cohort study in the UK and Ireland that aims to examine midlife risk factors for dementia and identify and describe the earliest indices of disease development. The PREVENT dementia programme is one of…
View article: A history of traumatic brain injury is associated with poorer cognition and imaging evidence of altered white matter tract integrity in UK Biobank (<i>n</i> = 50 376)
A history of traumatic brain injury is associated with poorer cognition and imaging evidence of altered white matter tract integrity in UK Biobank (<i>n</i> = 50 376) Open
Traumatic brain injury (TBI) is a risk factor for neurodegenerative disease. We currently have no means to identify patients most at risk of neurodegenerative disease following injury and, resultantly, no means to target risk mitigation in…
View article: Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data
Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data Open
Participant motion in brain magnetic resonance imaging is associated with processing problems including potentially non-useable/incomplete data. This has implications for representativeness in research. Few large studies have investigated …
View article: <i>APOE</i> ɛ4 exacerbates age-dependent deficits in cortical microstructure
<i>APOE</i> ɛ4 exacerbates age-dependent deficits in cortical microstructure Open
The apolipoprotein E ɛ4 allele is the primary genetic risk factor for the sporadic type of Alzheimer’s disease. However, the mechanisms by which apolipoprotein E ɛ4 are associated with neurodegeneration are still poorly understood. We appl…
View article: Increased risk of lower limb osteoarthritis among former professional soccer (football) players
Increased risk of lower limb osteoarthritis among former professional soccer (football) players Open
Background Soccer is a high-speed contact sport with risk of injury. Despite long-standing concern, evidence to date remains inconsistent as to the association between playing professional-level soccer and lifelong musculoskeletal conseque…
View article: The neuropathology of intimate partner violence
The neuropathology of intimate partner violence Open
View article: Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career
Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career Open
No abstract available.
View article: Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2 Open
View article: Effect of thymosin β4 on lipopolysaccharide‑stimulated brain microvascular endothelial cell remodeling: A possible role in blood‑brain barrier injury
Effect of thymosin β4 on lipopolysaccharide‑stimulated brain microvascular endothelial cell remodeling: A possible role in blood‑brain barrier injury Open
War veterans, in particular, are more prone to mental illness as they are more likely to have encountered multiple traumatic brain injuries (TBIs) whilst serving on active duty in war zone areas. A TBI is known to cause mortality or seriou…
View article: The PREVENT Dementia programme: Baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia
The PREVENT Dementia programme: Baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia Open
PREVENT is a multi-centre prospective cohort study in the UK and Ireland that aims to examine mid-life risk factors for dementia, identify and describe the earliest indices of disease development. The PREVENT dementia programme is one of t…
View article: HEalth And Dementia outcomes following Traumatic Brain Injury (HEAD-TBI): protocol for a retrospective cohort study
HEalth And Dementia outcomes following Traumatic Brain Injury (HEAD-TBI): protocol for a retrospective cohort study Open
Background It is estimated that by 2050 the global incidence of dementia will have exceeded 152 million. At present, there are no effective therapies for dementia, with a focus in research now turning to strategies for disease prevention. …
View article: Head motion in the UK Biobank imaging sub-sample: longitudinal stability, associations with psychological and physical health, and risk of non-useable data
Head motion in the UK Biobank imaging sub-sample: longitudinal stability, associations with psychological and physical health, and risk of non-useable data Open
Background: Participant motion in magnetic resonance imaging (MRI) is associated with processing problems including potentially non-useable data. This has implications for representativeness in research. Few large studies have investigated…
View article: The perils of contact sport: pathologies of diffuse brain swelling and chronic traumatic encephalopathy neuropathologic change in a 23-year-old rugby union player
The perils of contact sport: pathologies of diffuse brain swelling and chronic traumatic encephalopathy neuropathologic change in a 23-year-old rugby union player Open
View article: Data from A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma
Data from A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma Open
Purpose: To perform a two-cohort, phase I safety and immunogenicity study of IMA950 in addition to standard chemoradiotherapy and adjuvant temozolomide in patients with newly diagnosed glioblastoma. IMA950 is a novel glioblastoma-sp…
View article: Additional Tables and Figures from A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma
Additional Tables and Figures from A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma Open
Supplementary Table S1. TUMAPs contained in IMA950 and associated source antigens. Supplementary Table S2. Statistical analysis underlying the recruitment of 20 immune evaluable patients per cohort. Supplementary Table S3. Reasons for HLA-…
View article: Additional Tables and Figures from A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma
Additional Tables and Figures from A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma Open
Supplementary Table S1. TUMAPs contained in IMA950 and associated source antigens. Supplementary Table S2. Statistical analysis underlying the recruitment of 20 immune evaluable patients per cohort. Supplementary Table S3. Reasons for HLA-…