William V. Trim
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View article: The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism Open
APC, the core scaffold of the Wnt destruction complex, targets the transcriptional co-activator β-catenin for proteolysis. There is no convincing evidence that APC directs degradation of other substrates. Using a reconstituted cytosolic ex…
View article: Normalized Raman Imaging for Studies of Tissue Physiology of the Kidney
Normalized Raman Imaging for Studies of Tissue Physiology of the Kidney Open
Histology is the cornerstone of clinical pathology and an essential tool for many areas of medicine. Nevertheless, conventional histological methods, which rely on fixation, embedding, sectioning, and staining, distort cellular architectur…
View article: Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis Open
Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform …
View article: Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity
Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity Open
Background T-Lymphocyte activation is modulated by the adipokine leptin and serum concentrations of this hormone can be reduced with short-term calorie restriction. The aim of this study was to understand whether leptin per se is important…
View article: A Transcriptional Atlas Defining Metabolically Healthy and Unhealthy Obesity in Human Adipose Tissue and Liver
A Transcriptional Atlas Defining Metabolically Healthy and Unhealthy Obesity in Human Adipose Tissue and Liver Open
View article: Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases
Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases Open
Fibroblasts play critical roles in tissue homeostasis, but in pathologic states can drive fibrosis, inflammation, and tissue destruction. In the joint synovium, fibroblasts provide homeostatic maintenance and lubrication. Little is known a…
View article: The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males
The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males Open
NCT03594799 (registered July 20, 2018) (https://clinicaltrials.gov/ct2/show/NCT03594799).
View article: The Impact of Long-term Physical Inactivity on Adipose Tissue Immunometabolism
The Impact of Long-term Physical Inactivity on Adipose Tissue Immunometabolism Open
Context Adipose tissue and physical inactivity both influence metabolic health and systemic inflammation, but how adipose tissue responds to chronic physical inactivity is unknown. Objective This work aimed to characterize the impact of ch…
View article: The impact of long-term physical inactivity on adipose tissue immunometabolism
The impact of long-term physical inactivity on adipose tissue immunometabolism Open
These files constitute the Supplementary Materials for the manuscript titled: The impact of long-term physical inactivity on adipose tissue immunometabolism, submitted to JCEM.File List Summary:Supplementary Data File 1 Supplementary Figur…
View article: The effect of hydration status on plasma FGF21 concentrations in humans: A subanalysis of a randomised crossover trial
The effect of hydration status on plasma FGF21 concentrations in humans: A subanalysis of a randomised crossover trial Open
To our knowledge, these are the first causal data in humans investigating hydration and FGF21, demonstrating that an acute bout of hypohydration does not impact fasted plasma FGF21 concentrations. These data may suggest that whilst previou…
View article: Effect of Plain Versus Sugar‐Sweetened Breakfast on Energy Balance and Metabolic Health: A Randomized Crossover Trial
Effect of Plain Versus Sugar‐Sweetened Breakfast on Energy Balance and Metabolic Health: A Randomized Crossover Trial Open
Objective This study investigated the effect of 3 weeks of high‐sugar (“Sweet”) versus low‐sugar (“Plain”) breakfast on energy balance, metabolic health, and appetite. Methods A total of 29 healthy adults (22 women) completed this randomiz…
View article: Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity Open
Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations al…