William Valdar
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View article: Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine
Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine Open
Rationale Cocaine use disorder (CUD) is a significant health concern that has devastating impacts on affected individuals and society. There are currently no approved therapies to treat CUD due, in part, to significant gaps in our knowledg…
View article: The impact of early-life exposures on growth and adult gut microbiome composition is dependent on genetic strain and parent- of- origin
The impact of early-life exposures on growth and adult gut microbiome composition is dependent on genetic strain and parent- of- origin Open
Background Early-life exposure to environmental factors can have long-lasting impacts on offspring health into adulthood and therefore is an emerging public health concern. In particular, the impact of maternal environmental exposures such…
View article: Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes.
Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes. Open
Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which may be highly consequential in biomedicine. An effective approach to identifying G×T signals and gaining insight into molecular mechan…
View article: Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes
Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes Open
Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which can be highly consequential in biomedicine. An effective approach to identifying G×T signals and gaining insight into molecular mechan…
View article: Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes
Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes Open
Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which may be highly consequential in biomedicine. An effective approach to identifying G×T signals and gaining insight into molecular mechan…
View article: Early life exposure to vitamin D deficiency impairs molecular mechanisms that regulate liver cholesterol biosynthesis, energy metabolism, inflammation, and detoxification
Early life exposure to vitamin D deficiency impairs molecular mechanisms that regulate liver cholesterol biosynthesis, energy metabolism, inflammation, and detoxification Open
Introduction Emerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver function are being developed. Methods Here, we leveraged our Collaborati…
View article: Early life exposure to vitamin D deficiency impairs molecular mechanisms that regulate liver cholesterol biosynthesis, energy metabolism, inflammation, and detoxification
Early life exposure to vitamin D deficiency impairs molecular mechanisms that regulate liver cholesterol biosynthesis, energy metabolism, inflammation, and detoxification Open
Introduction Emerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver function are being developed. Methods Here, we leveraged our Collaborati…
View article: Sarbecovirus disease susceptibility is conserved across viral and host models
Sarbecovirus disease susceptibility is conserved across viral and host models Open
Coronaviruses have caused three severe epidemics since the start of the 21 st century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater under…
View article: Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets
Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets Open
Background The gut microbiota is modulated by a combination of diet, host genetics, and sex effects. The magnitude of these effects and interactions among them is important to understanding inter-individual variability in gut microbiota. I…
View article: A mutation in<i>Themis</i>contributes to peanut-induced oral anaphylaxis in CC027 mice
A mutation in<i>Themis</i>contributes to peanut-induced oral anaphylaxis in CC027 mice Open
Background The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut- sensitized CC027/GeniUnc (CC027) mic…
View article: Navigating the bridge between wet and dry lab toxicology research to address current challenges with high-dimensional data
Navigating the bridge between wet and dry lab toxicology research to address current challenges with high-dimensional data Open
Toxicology research has rapidly evolved, leveraging increasingly advanced technologies in high-throughput approaches to yield important information on toxicological mechanisms and health outcomes. Data produced through toxicology studies a…
View article: Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets
Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets Open
Background The gut microbiota is modulated by a combination of diet, host genetics, and sex effects. The magnitude of these effects and interactions among them is important to understanding inter-individual variability in gut microbiota. I…
View article: Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats
Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats Open
Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identi…
View article: Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats
Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats Open
Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identi…
View article: Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats
Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats Open
Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identi…
View article: A Bayesian model selection approach to mediation analysis
A Bayesian model selection approach to mediation analysis Open
Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an inte…
View article: A Bayesian model selection approach to mediation analysis
A Bayesian model selection approach to mediation analysis Open
Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an inte…
View article: Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity
Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity Open
Transcriptomic analysis in metabolically active tissues allows a systems genetics approach to identify causal genes and networks involved in metabolic disease. Outbred heterogeneous stock (HS) rats are used for genetic mapping of complex t…
View article: Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats
Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats Open
Obesity is a growing epidemic associated with a range of comorbidities, including anxiety and depression. Genetics and environmental factors such as diet contribute to both adiposity and anxiety/depression. Heterogeneous stock (HS) rats ar…
View article: Transcriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Genetic Regulatory Mechanisms Relevant for Human Obesity
Transcriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Genetic Regulatory Mechanisms Relevant for Human Obesity Open
Transcriptomic analysis in metabolically active tissues allows a systems genetics approach to identify causal genes and networks involved in metabolic disease. Outbred heterogeneous stock (HS) rats are used for genetic mapping of complex t…
View article: Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats
Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats Open
Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identi…
View article: Supplementary Information for WGCNA manuscript
Supplementary Information for WGCNA manuscript Open
Supplementary Tables and Figures for the manuscript:Transcriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Genetic Regulatory Mechanisms Relevant for Human Obesity
View article: A Bayesian model selection approach to mediation analysis
A Bayesian model selection approach to mediation analysis Open
Mediation analysis is a powerful tool for discovery of causal relationships. We describe a Bayesian model selection approach to mediation analysis that is implemented in our bmediatR software. Using simulations, we show that bmediatR perfo…
View article: Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel <i>Xce</i> allele associated with copy number changes
Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel <i>Xce</i> allele associated with copy number changes Open
Female mammals are functional mosaics of their parental X-linked gene expression due to X chromosome inactivation (XCI). This process inactivates one copy of the X chromosome in each cell during embryogenesis and that state is maintained c…
View article: Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel<i>Xce</i>allele associated with copy number changes
Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel<i>Xce</i>allele associated with copy number changes Open
Female mammals are functional mosaics of their parental X-linked gene expression due to X chromosome inactivation (XCI). This process inactivates one copy of the X chromosome in each cell during embryogenesis and that state is maintained c…