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View article: OSA SCREENING IN HEART FAILURE: QUALITY ASSESSMENT OF AN ACADEMIC INTERNAL MEDICINE CLINIC
OSA SCREENING IN HEART FAILURE: QUALITY ASSESSMENT OF AN ACADEMIC INTERNAL MEDICINE CLINIC Open
View article: A model of the aged lung epithelium in idiopathic pulmonary fibrosis
A model of the aged lung epithelium in idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is an age-related disorder that carries a universally poor prognosis and is thought to arise from repetitive micro injuries to the alveolar epithelium. To date, a major factor limiting our understanding …
View article: What Happens to the Lungs When They Get Hurt?
What Happens to the Lungs When They Get Hurt? Open
Lung fibrosis is a lung disease that primarily affects older adults and makes it hard to breathe. The lungs get scarred and thick from inflammation, so exchange of oxygen and carbon dioxide is impaired. In this article, you will first lear…
View article: TP53 Expression Is Altered in the Alveolar Epithelium in Hermansky-Pudlak Syndrome
TP53 Expression Is Altered in the Alveolar Epithelium in Hermansky-Pudlak Syndrome Open
View article: Senescent Alveolar Type 2 Cells Exhibit an Unique Metabolomics Profile
Senescent Alveolar Type 2 Cells Exhibit an Unique Metabolomics Profile Open
View article: Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung
Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung Open
Background Mitochondrial dysfunction has emerged as an important player in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a common cause of idiopathic interstitial lung disease in adults. Hermansky-Pudlak syndrome (HPS) is a rare…
View article: Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids Open
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease of unknown etiology with limited treatment options. It is characterized by repetitive injury to alveolar epithelial cells and aberrant activation of numerous sig…
View article: Matched Cohort Study of Convalescent COVID-19 Plasma Treatment in Severely or Life Threateningly Ill COVID-19 Patients
Matched Cohort Study of Convalescent COVID-19 Plasma Treatment in Severely or Life Threateningly Ill COVID-19 Patients Open
Background The utility of convalescent coronavirus disease 2019 (COVID-19) plasma (CCP) in the current pandemic is not well defined. We sought to evaluate the safety and efficacy of CCP in severely or life threateningly ill COVID-19 patien…
View article: MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease
MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease Open
The pathogenesis of chronic obstructive pulmonary disease (COPD) involves aberrant responses to cellular stress caused by chronic cigarette smoke (CS) exposure. However, not all smokers develop COPD and the critical mechanisms that regulat…
View article: A TURBULENT DIAGNOSIS OF SMALL-CELL LUNG CARCINOMA SAVED BY THE LIVER
A TURBULENT DIAGNOSIS OF SMALL-CELL LUNG CARCINOMA SAVED BY THE LIVER Open
View article: FACTORS ASSOCIATED WITH IN-HOSPITAL MORTALITY IN PATIENTS WITH OSA: A NATIONWIDE PERSPECTIVE
FACTORS ASSOCIATED WITH IN-HOSPITAL MORTALITY IN PATIENTS WITH OSA: A NATIONWIDE PERSPECTIVE Open
View article: A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis
A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis Open
Pulmonary fibrosis is a chronic and progressive lung disease characterized by the activation of fibroblasts and the irreversible deposition of connective tissue matrices that leads to altered pulmonary architecture and physiology. Multiple…
View article: Decreased miR-24-3p potentiates DNA damage responses and increases susceptibility to COPD
Decreased miR-24-3p potentiates DNA damage responses and increases susceptibility to COPD Open
Activation of the DNA damage response (DDR) due to chronic exposure to cigarette smoke (CS) is implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). However, not all smokers develop COPD and the pathologic consequ…
View article: Transcriptomics, metabolomics and lipidomics of chronically injured alveolar epithelial cells reveals similar features of IPF lung epithelium
Transcriptomics, metabolomics and lipidomics of chronically injured alveolar epithelial cells reveals similar features of IPF lung epithelium Open
The current hypothesis suggests that Idiopathic pulmonary fibrosis (IPF) arises as a result of chronic injury to alveolar epithelial cells and aberrant activation of multiple signaling pathways. Dysfunctional IPF lung epithelium manifests …
View article: Comparison of Measured Versus Calculated Maximum Voluntary Ventilation for Determining Ventilatory Limitation in Veterans with Unexplained Dyspnea
Comparison of Measured Versus Calculated Maximum Voluntary Ventilation for Determining Ventilatory Limitation in Veterans with Unexplained Dyspnea Open
View article: Impaired HSF1 Transactivation by Sumoylation Drives Cellular Senescence in Lung Fibroblast
Impaired HSF1 Transactivation by Sumoylation Drives Cellular Senescence in Lung Fibroblast Open
View article: RNA-seq Transcriptome Analysis of Chronic Injured Lung Epithelial Cells Reveals Similar Features of IPF Lung Epithelium
RNA-seq Transcriptome Analysis of Chronic Injured Lung Epithelial Cells Reveals Similar Features of IPF Lung Epithelium Open
View article: Septic Pulmonary Emboli Secondary to Infective Endocarditis
Septic Pulmonary Emboli Secondary to Infective Endocarditis Open
View article: TCF11/Nrf1-Mediated Activation of Proteasome Expression Is Compromised in Chronically Injured Alveolar Epithelial Cells and Aged-Related Lung Fibrosis
TCF11/Nrf1-Mediated Activation of Proteasome Expression Is Compromised in Chronically Injured Alveolar Epithelial Cells and Aged-Related Lung Fibrosis Open
View article: The Integrated Stress-ATF4 Pathway Drives Cellular Senescence in Alveolar Epithelial Cells
The Integrated Stress-ATF4 Pathway Drives Cellular Senescence in Alveolar Epithelial Cells Open
View article: Pyoderma gangrenosum in a patient with type 2 diabetes: a case report
Pyoderma gangrenosum in a patient with type 2 diabetes: a case report Open
We are presenting a case of patient with type 2 diabetes mellitus that was diagnosed with a soft tissue infection in the lower extremity. This was initially treated as cellulitis and antibiotic treatment was initiated. Due to a poor clinic…
View article: Pyoderma gangrenosum in a tipe 2 diabetic patient: a case report
Pyoderma gangrenosum in a tipe 2 diabetic patient: a case report Open
We are presenting a case of patient with type 2 diabetes mellitus that was diagnosed with a soft tissue infection in the lower extremity. This was initially treated as cellulitis and antibiotic treatment was initiated. Due to a poor clinic…
View article: Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis
Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis. The development of an effective treatment for …
View article: DISSEMINATED TB WITH PERITONEAL INVOLVEMENT ASSOCIATED WITH ADALIMUMAB THERAPY
DISSEMINATED TB WITH PERITONEAL INVOLVEMENT ASSOCIATED WITH ADALIMUMAB THERAPY Open
View article: Massive right atrial thrombus
Massive right atrial thrombus Open
View article: Spontaneous tumor lysis syndrome in T-cell malignancy: two case reports
Spontaneous tumor lysis syndrome in T-cell malignancy: two case reports Open
Tumor lysis syndrome (TLS) refers to a constellation of metabolic abnormalities that result from release of intracellular solutes (potassium, phosphate, and nucleic acid metabolites) from rapidly dying tumor cells. While TLS most commonly …
View article: Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease
Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease Open
In CKD patients, the PRF thickness correlated significantly with metabolic risk factors that could affect kidney function.
View article: Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium Open
Cellular senescence is a biological process by which cells lose their capacity to proliferate yet remain metabolically active. Although originally considered a protective mechanism to limit the formation of cancer, it is now appreciated th…