Wilson Wei Sheng Tan
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View article: A Comparative Study of Multimodal Projection in The Analects of Confucius
A Comparative Study of Multimodal Projection in The Analects of Confucius Open
Please refer to the URL that includes this article for the abstract.
View article: Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized hACE2 NIKO mouse model
Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized hACE2 NIKO mouse model Open
The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe …
View article: Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized AdV-hACE2 NIKO mouse model
Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized AdV-hACE2 NIKO mouse model Open
The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe …
View article: Successful targeting of PD-1/PD-L1 with chimeric antigen receptor-natural killer cells and nivolumab in a humanized mouse cancer model
Successful targeting of PD-1/PD-L1 with chimeric antigen receptor-natural killer cells and nivolumab in a humanized mouse cancer model Open
In recent decades, chimeric antigen receptor (CAR)–engineered immune effector cells have demonstrated promising antileukemic activity. Nevertheless, their efficacy remains unsatisfactory on solid cancers, plausibly due to the influence of …
View article: Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer
Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer Open
Fatty acid oxidation is a metabolic gateway that regulates cellular plasticity and supports metastasis in breast cancer.
View article: Analysis and Validation of Human Targets and Treatments Using a Hepatocellular Carcinoma–Immune Humanized Mouse Model
Analysis and Validation of Human Targets and Treatments Using a Hepatocellular Carcinoma–Immune Humanized Mouse Model Open
Background and Aims Recent development of multiple treatments for human hepatocellular carcinoma (HCC) has allowed for the selection of combination therapy to enhance the effectiveness of monotherapy. Optimal selection of therapies is base…
View article: Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics
Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics Open
Advancements in science enable researchers to constantly innovate and create novel biologics. However, the use of non-human animal models during the development of biologics impedes identification of precise in vivo interactions bet…
View article: CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice
CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice Open
Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) i…
View article: Establishment and Characterization of Humanized Mouse NPC-PDX Model for Testing Immunotherapy
Establishment and Characterization of Humanized Mouse NPC-PDX Model for Testing Immunotherapy Open
Immune checkpoint blockade (ICB) monotherapy shows early promise for the treatment of nasopharyngeal carcinoma (NPC) in patients. Nevertheless, limited representative NPC models hamper preclinical studies to evaluate the efficacy of novel …
View article: A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions
A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions Open
Recently a G-protein-coupled receptor, MAS Related GPR Family Member X2 (MRGPRX2), was identified as a specific receptor on human mast cells responsible for IgE independent adverse drug reactions (ADR). Although a murine homologue, Mrgprb2…
View article: Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system
Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system Open
Bats are an important animal model with long lifespans, low incidences of tumorigenesis and an ability to asymptomatically harbour pathogens. Currently, in vivo studies of bats are hampered due to their low reproduction rates. To overcome …
View article: A Novel Human Systemic Lupus Erythematosus Model in Humanised Mice
A Novel Human Systemic Lupus Erythematosus Model in Humanised Mice Open
Mouse models have contributed to the bulk of knowledge on Systemic Lupus Erythematosus (SLE). Nevertheless, substantial differences exist between human and mouse immune system. We aimed to establish and characterise a SLE model mediated by…
View article: An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia
An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia Open
Collectively, our improved model is robust, easy-to-construct, and reliable for pre-clinical AML studies.
View article: Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis
Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis Open
Berberine exerted anti-cancer effect in various cancer cell lines, and was also implied in the treatment of metabolic related diseases. Given the metabolic modulation, we hypothesized that berberine possessed anti-cancer effect under the a…