Wim J. R. Rietdijk
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View article: Differences in antihypertensive drug blood levels in patients with hypertension (DECISION): a prospective study comparing pharmacokinetics and pharmacodynamics of perindopril in younger and older patients
Differences in antihypertensive drug blood levels in patients with hypertension (DECISION): a prospective study comparing pharmacokinetics and pharmacodynamics of perindopril in younger and older patients Open
Older adults exhibited higher perindoprilat exposure than younger adults, alongside an exploratory, nonsignificant trend toward greater systolic BP reduction. Given the limited sample size, no causal inference can be drawn from our data; n…
View article: Ketogenic diet therapy enables antiseizure medication reduction and withdrawal in children with epilepsy
Ketogenic diet therapy enables antiseizure medication reduction and withdrawal in children with epilepsy Open
KDT is effective in enabling ASM withdrawal in one-fourth of the responding pediatric patients. Younger age and fewer initial ASMs predicted better withdrawal outcomes, supporting early ASM withdrawal within 3-6 months of KDT for appropria…
View article: The validity and reliability of the Dutch version of the Student Satisfaction and Self-Confidence in Learning Scale (SCLC) for pharmacy technicians
The validity and reliability of the Dutch version of the Student Satisfaction and Self-Confidence in Learning Scale (SCLC) for pharmacy technicians Open
Background The Student Satisfaction and Self-Confidence in Learning Scale (SCLC) is widely used to measure satisfaction and self-confidence in learning. The 13-item scale includes two subscales: satisfaction with education (5 items) and se…
View article: Evaluation of Sex‐Based Differences in the Prescription of the Combination of Evidence‐Based Medicine After the Occurrence of an Acute ST‐Elevation Myocardial Infarction
Evaluation of Sex‐Based Differences in the Prescription of the Combination of Evidence‐Based Medicine After the Occurrence of an Acute ST‐Elevation Myocardial Infarction Open
Aim To evaluate sex‐based differences in the prescription of the combination of evidence‐based medicine (cEBM) at discharge after an acute ST‐elevation myocardial infarction (STEMI). Secondly, we analysed risk factors for the absence of cE…
View article: Kinaesthetic empathy through the lens of the cinematographer: physiological and phenomenological alignments in the act of creation
Kinaesthetic empathy through the lens of the cinematographer: physiological and phenomenological alignments in the act of creation Open
Film and actor-driven narratives showcase a structured and authentic depiction of emotions, and are considered a reliable resource for validating affective states when coupled with physiological data. In affective computing studies, emotio…
View article: Thrombectomy in high-risk pulmonary embolism – device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial
Thrombectomy in high-risk pulmonary embolism – device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial Open
TORPEDO-NL is the first publicly-funded randomized trial to investigate the effect of CDT treatment specifically in high-risk PE patients. The trial is anticipated to play an important role in revising recommendations for high-risk PE trea…
View article: Correction: Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial
Correction: Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial Open
View article: Study protocol for a multicentre randomised controlled trial using music prehabilitation to reduce preoperative anxiety before oncological colorectal surgery: the MU-PRIOR trial
Study protocol for a multicentre randomised controlled trial using music prehabilitation to reduce preoperative anxiety before oncological colorectal surgery: the MU-PRIOR trial Open
Introduction Prehabilitation aims to improve preoperative health before surgery to reduce complications. Reducing anxiety helps prevent postoperative pain, stress and sleep disturbances. Listening to music through headphones or earpieces i…
View article: Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial
Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial Open
Background Sepsis and septic shock are significant global healthcare challenges with high mortality rates. Effective management requires timely and adequate antimicrobial therapy. Beta-lactam antibiotics, commonly used in patients with sep…
View article: Prevalence and Incidence of Oral Benzodiazepine Use in Hospitalized Surgical Patients
Prevalence and Incidence of Oral Benzodiazepine Use in Hospitalized Surgical Patients Open
Objective: To determine the prevalence of intrahospital oral benzodiazepine use in the surgical population of a tertiary care centre. Summary of Background Data: Oral benzodiazepines used for treating sleep disturbances and anxiety are wid…
View article: Thrombectomy in High-Risk Pulmonary Embolism – Device Versus Thrombolysis: Rationale and Design of the Torpedo-Nl Investigator-Initiated, Academically-Sponsored, Multicenter, Open-Label Randomized Controlled Trial
Thrombectomy in High-Risk Pulmonary Embolism – Device Versus Thrombolysis: Rationale and Design of the Torpedo-Nl Investigator-Initiated, Academically-Sponsored, Multicenter, Open-Label Randomized Controlled Trial Open
View article: The effect of sleep and shift work on the primary immune response to messenger <scp>RNA</scp>‐based <scp>COVID</scp>‐19 vaccination
The effect of sleep and shift work on the primary immune response to messenger <span>RNA</span>‐based <span>COVID</span>‐19 vaccination Open
Summary Shift work can cause circadian misalignment, which often results in sleeping problems and has been associated with immune dysfunction. To better understand the impact of shift work on a primary immune response to vaccination, we co…
View article: Constructing a measure for self-perceived open organizational culture in a university hospital pharmacy
Constructing a measure for self-perceived open organizational culture in a university hospital pharmacy Open
Background An open organizational culture in the workplace represents an environment where information, ideas, and feedback are freely exchanged among all members, regardless of position or rank. Currently, there are no valid survey instru…
View article: Target attainment of beta-lactam antibiotics and ciprofloxacin in critically ill patients and its association with 28-day mortality
Target attainment of beta-lactam antibiotics and ciprofloxacin in critically ill patients and its association with 28-day mortality Open
A high rate of target attainment (100 % ƒT>1xECOFF) for beta-lactams and a lower rate for ciprofloxacin was observed. Achieving exposures of 100 % ƒT>4xECOFF was associated with 28-day mortality. The impact of antibio…
View article: Emergency Department Triage, Transfer Times, and Hospital Mortality of Patients Admitted to the ICU: A Retrospective Replication and Continuation Study*
Emergency Department Triage, Transfer Times, and Hospital Mortality of Patients Admitted to the ICU: A Retrospective Replication and Continuation Study* Open
OBJECTIVES: This study aimed to provide new insights into the impact of emergency department (ED) to ICU time on hospital mortality, stratifying patients by academic and nonacademic teaching (NACT) hospitals, and considering Acute Physiolo…
View article: Evaluation of a group-based online informed consent conversation (eConsent) in participants from a low-risk vaccination clinical trial
Evaluation of a group-based online informed consent conversation (eConsent) in participants from a low-risk vaccination clinical trial Open
Background Electronic informed consent (eConsent) usage has expanded in recent years in Europe, especially during the pandemic. Slow recruitment rate and limitations in participant outreach are the challenges often faced in clinical resear…
View article: Intra-aortic balloon pump for ST-elevation myocardial infarction necessitating urgent coronary artery bypass grafting, still a valid indication?
Intra-aortic balloon pump for ST-elevation myocardial infarction necessitating urgent coronary artery bypass grafting, still a valid indication? Open
View article: Repeated COVID-19 Vaccination Drives Memory T- and B-cell Responses in Kidney Transplant Recipients: Results From a Multicenter Randomized Controlled Trial
Repeated COVID-19 Vaccination Drives Memory T- and B-cell Responses in Kidney Transplant Recipients: Results From a Multicenter Randomized Controlled Trial Open
Background. Insight into cellular immune responses to COVID-19 vaccinations is crucial for optimizing booster programs in kidney transplant recipients (KTRs). Methods. In an immunologic substudy of a multicenter randomized controlled trial…
View article: Original COVID-19 priming regimen impacts the immunogenicity of bivalent BA.1 and BA.5 boosters
Original COVID-19 priming regimen impacts the immunogenicity of bivalent BA.1 and BA.5 boosters Open
View article: Differences in prescribing errors between electronic prescribing and traditional prescribing among medical students: A randomized pilot study
Differences in prescribing errors between electronic prescribing and traditional prescribing among medical students: A randomized pilot study Open
Aims This randomized controlled pilot study aimed to assess the differences in the frequency, type and severity of prescribing errors made by medical students when assessed in an electronic (e‐)prescribing system compared to a traditional …
View article: Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients
Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients Open
Kidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses d…
View article: Exploring the Impact of Model-Informed Precision Dosing on Procalcitonin Concentrations in Critically Ill Patients: A Secondary Analysis of the DOLPHIN Trial
Exploring the Impact of Model-Informed Precision Dosing on Procalcitonin Concentrations in Critically Ill Patients: A Secondary Analysis of the DOLPHIN Trial Open
Model-informed precision dosing (MIPD) might be used to optimize antibiotic treatment. Procalcitonin (PCT) is a biomarker for severity of infection and response to antibiotic treatment. The aim of this study was to assess the impact of MIP…
View article: Differences in Prescribing Errors Between Electronic Prescribing and Traditional Prescribing among Medical Students: a randomized pilot study
Differences in Prescribing Errors Between Electronic Prescribing and Traditional Prescribing among Medical Students: a randomized pilot study Open
Aims This randomized controlled pilot study aimed to assess the differences in the frequency, type, and severity of prescribing errors made by medical students when assessed in an electronic prescribing system (EPS) compared to traditional…
View article: Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial
Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial Open
View article: Human resource management at the intensive care unit: <scp>A</scp> pragmatic review and future research agenda for building a learning health system
Human resource management at the intensive care unit: <span>A</span> pragmatic review and future research agenda for building a learning health system Open
Recently, the importance of efficient and effective health care has been recognized, especially during the acute phase of the Coronavirus Disease‐2019 (COVID‐19) pandemic. Intensive care units (ICUs) have faced an immense workload, with ma…
View article: Eligibility of cardiac arrest patients for extracorporeal cardiopulmonary resuscitation and their clinical characteristics: a retrospective two-centre study
Eligibility of cardiac arrest patients for extracorporeal cardiopulmonary resuscitation and their clinical characteristics: a retrospective two-centre study Open
Background and importance Sudden cardiac arrest has a high incidence and often leads to death. A treatment option that might improve the outcomes in refractory cardiac arrest is Extracorporeal Cardiopulmonary Resuscitation (ECPR). Objectiv…
View article: Distinct COVID-19 vaccine combinations result in divergent immune responses
Distinct COVID-19 vaccine combinations result in divergent immune responses Open
Summary Waning antibody responses after COVID-19 vaccination combined with the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness. As a countermeasure, bivalent mRNA-based booster vaccines encoding the ancestr…
View article: Which patients benefit from model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin at the ICU?
Which patients benefit from model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin at the ICU? Open
ICU patients with a SOFA below 8 using MIPD had an increased ICU LOS but a lower 28-day mortality. Fast dose recommendations using MIPD of beta-lactam antibiotics and ciprofloxacin needs to be investigated in ICU patients.
View article: Cardiac Rhythm Changes During Transfer from the Emergency Medical Service to the Emergency Department: A Retrospective Tertiary Single-Center Analysis on Prevalence and Outcomes
Cardiac Rhythm Changes During Transfer from the Emergency Medical Service to the Emergency Department: A Retrospective Tertiary Single-Center Analysis on Prevalence and Outcomes Open
Cardiac rhythm changes can occur in OHCA patients during transfer from EMS to the ED. Our results showed some evidence that these changes are associated with a lower ED survival.
View article: The role of interleukin-21 in COVID-19 vaccine–induced B cell–mediated immune responses in patients with kidney disease and kidney transplant recipients
The role of interleukin-21 in COVID-19 vaccine–induced B cell–mediated immune responses in patients with kidney disease and kidney transplant recipients Open