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View article: L-Ascorbic Acid (LAA) Supplementation Enhances Proliferation and Reduces Cellular Senescence in Adipose-Tissue Mesenchymal Stem Cells (AT-MSC) Without Altering Characterization
L-Ascorbic Acid (LAA) Supplementation Enhances Proliferation and Reduces Cellular Senescence in Adipose-Tissue Mesenchymal Stem Cells (AT-MSC) Without Altering Characterization Open
Adipose-tissue mesenchymal stem cells (AT-MSCs) and their secretome have been widely utilized in the field of anti-aging and regenerative medicine. However, the number of AT-MSCs declines during subculture due to cellular senescence. The a…
View article: L-Ascorbic Acid (LAA) Supplementation as a Potential Treatment for Skin Aging: Regulation of Adipose Tissue Mesenchymal Stem Cells (AT-MSCs) Protein Secretion
L-Ascorbic Acid (LAA) Supplementation as a Potential Treatment for Skin Aging: Regulation of Adipose Tissue Mesenchymal Stem Cells (AT-MSCs) Protein Secretion Open
Skin aging is mostly caused by the accumulation of reactive oxygen species (ROS) that lead to cellular dysfunction. One promising therapy for skin aging is the secretome product of adipose tissue mesenchymal stem cells (AT-MSCs). L-ascorbi…
View article: L-ascorbic acid (LAA) Supplementation in Adipose-Tissue Mesenchymal Stem Cells (AT-MSC) Culture Induce Proliferation and Prevent Cellular Senescent without Altering Mesenchymal Stem Cells (MSC) Characterization
L-ascorbic acid (LAA) Supplementation in Adipose-Tissue Mesenchymal Stem Cells (AT-MSC) Culture Induce Proliferation and Prevent Cellular Senescent without Altering Mesenchymal Stem Cells (MSC) Characterization Open
Background Adipose-tissue mesenchymal stem cells (AT-MSCs) and its secretome has been used widely in the field of anti-aging and regenerative medicine. However, the number of AT-MSCs decreases during subculture caused by the cell senescenc…
View article: Inhibition of Ultraviolet B-induced Apoptosis in Fibroblasts by Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Media via the Phosphatidylinositol-3-Kinase/Akt Pathway.
Inhibition of Ultraviolet B-induced Apoptosis in Fibroblasts by Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Media via the Phosphatidylinositol-3-Kinase/Akt Pathway. Open
Taken together, it can be concluded that CM-hUCB-MSC inhibits UVB-induced NIH3T3 cell apoptosis via the activation of phosphatidylinositol-3-kinase (PI3K)/Akt signaling cascades.
View article: The Addition of Astaxanthin 0.5% in Sunscreen SPF 50 Inhibits the Increase of Sunburn Cells in Rats Induced By Ultraviolet Light B
The Addition of Astaxanthin 0.5% in Sunscreen SPF 50 Inhibits the Increase of Sunburn Cells in Rats Induced By Ultraviolet Light B Open
Long-term exposure to ultraviolet light can cause chronic inflammation that can damage collagen and increase sunburn cells known as photoaging. There is a prevalence of up to 69% in female students in Jakarta aged 18–21 years who experienc…
View article: Papaya Leaf Ethanol Extract Lowers Malondialdehyde Levels, Increases Superoxide Dismutase Levels, and Increases Leydig Cell Count in Male Rats Given High-Intensity Swimming Exercise
Papaya Leaf Ethanol Extract Lowers Malondialdehyde Levels, Increases Superoxide Dismutase Levels, and Increases Leydig Cell Count in Male Rats Given High-Intensity Swimming Exercise Open
Physical activity is any body movement that occurs due to skeletal muscle contractions that require energy expenditure. Overtraining can trigger oxidative stress due to chronic systemic hypoxia, cause an increase in systemic inflammatory r…
View article: Administration of Corosolic Acid Decreased MDA, HMG-CoA, Through Increased Leptin and GLP-1 Levels in Obese Male Rats
Administration of Corosolic Acid Decreased MDA, HMG-CoA, Through Increased Leptin and GLP-1 Levels in Obese Male Rats Open
Obesity is a condition where excessive fat is accumulated, which poses a health risk. Several treatments for obesity have been carried out, ranging from lifestyle adjustments to medication to surgery. Corrosolic acid (CA) is a natural comp…
View article: Potential Utilisation of Secretome from Ascorbic Acid-Supplemented Stem Cells in Combating Skin Aging: Systematic Review of A Novel Idea.
Potential Utilisation of Secretome from Ascorbic Acid-Supplemented Stem Cells in Combating Skin Aging: Systematic Review of A Novel Idea. Open
The secretome of stem cells consists of a spectrum of bioactive factors secreted by stem cells grown in culture mediacytokines, chemokines, and growth factors in addition to extracellular vesicles (exosomes and microvesicles). Ease of hand…
View article: The Administration of 2% Plum (Prunus domestica L.) Extract Cream Inhibited the Increase of Tyrosinase Enzyme Expression and the Amount of Skin Melanin in Male Guinea Pigs (Cavia porcellus) Skin Exposed to UV B Light
The Administration of 2% Plum (Prunus domestica L.) Extract Cream Inhibited the Increase of Tyrosinase Enzyme Expression and the Amount of Skin Melanin in Male Guinea Pigs (Cavia porcellus) Skin Exposed to UV B Light Open
Medical science has progressed a lot and Anti Aging Medicine (AAM) is one of the sciences in the medical world that brings a new paradigm. Hyperpigmentation is one of the most common skin problems caused by excessive pigment melanin produc…
View article: Effect of Extract of Basil Leaf (Ocimum Basillicum L) on Ovarian Follice and Estrogen Level in Premenopausal Wistar Rats
Effect of Extract of Basil Leaf (Ocimum Basillicum L) on Ovarian Follice and Estrogen Level in Premenopausal Wistar Rats Open
Introduction:The decrease of estrogen in the aging process causes various complaints in women.This causes limitations in physical activity which ultimately reduces the quality of life.The use of phytopharmaca that has phytoestrogen activit…
View article: The Administration of Goroho Banana (Musa Acuminata Sp.) Peel Extract Reduces Weight, Increases Number of Leydig Cells and Testosterone Level in Male Wistar Rats (Rattus norvegicus) with Obesity
The Administration of Goroho Banana (Musa Acuminata Sp.) Peel Extract Reduces Weight, Increases Number of Leydig Cells and Testosterone Level in Male Wistar Rats (Rattus norvegicus) with Obesity Open
Oxidative stress can cause obesity, reduce both the number of Leydig cells and serum testosterone levels, thus triggering aging process.Goroho banana peel (Musa acuminata sp.) contains antioxidants to neutralize free radicals to maintain o…
View article: Administration Of 45% Robusta (Coffea canephora) Green Coffee Bean Ethanol Extract Solution Could Not Increased Hair Growth But Inhibited The Increase Of 5α-Reductase Type 1 Levels In Male Wistar Rats (Rattus norvegicus) Exposed To Topical Testosterone
Administration Of 45% Robusta (Coffea canephora) Green Coffee Bean Ethanol Extract Solution Could Not Increased Hair Growth But Inhibited The Increase Of 5α-Reductase Type 1 Levels In Male Wistar Rats (Rattus norvegicus) Exposed To Topical Testosterone Open
Background: Hair loss can occur due to disturbances in the follicular cycle. The most common type of hair loss is androgenetic alopecia, which occurs as a result of androgen hormone stimulation of the hair follicles, causing a transition f…
View article: Administration Of 30% Robusta Coffee (Coffea canephora) Silverskin Ethyl Acetate Fraction Cream Inhibited The Increase Of MITF Expression And Melanin Amount In The Skin Of Male Adult Guinea Pig (Cavia porcellus) Exposed To Ultraviolet B Ray
Administration Of 30% Robusta Coffee (Coffea canephora) Silverskin Ethyl Acetate Fraction Cream Inhibited The Increase Of MITF Expression And Melanin Amount In The Skin Of Male Adult Guinea Pig (Cavia porcellus) Exposed To Ultraviolet B Ray Open
Background: Melanin is produced through melanogenesis which involves several molecular processes with microphthalmia-associated transcription factor (MITF) as the main regulator of melanin synthesis. Hyperpigmentation is one of aging sign …
View article: Peppermint Leaf Extract Cream Increased Transforming Growth Factor β (TGF-β) Expression and Collagen Amount In The Male Wistar Rat's Skin Exposed to UVB
Peppermint Leaf Extract Cream Increased Transforming Growth Factor β (TGF-β) Expression and Collagen Amount In The Male Wistar Rat's Skin Exposed to UVB Open
Peppermint leaves contain flavonoids, menthofuran, and other phenolic compounds that have antioxidant activity and are believed to inhibit collagen degradation in the skin. This study investigated the efficacy of a 5% peppermint leaf extra…
View article: The Administration of Cordyceps Militaris Inhibited the Decrease of Leydig Cell Number and Testosterone Level in Male Wistar Rats (Rattus Norvegicus) Exposed with Cigarette Smoke
The Administration of Cordyceps Militaris Inhibited the Decrease of Leydig Cell Number and Testosterone Level in Male Wistar Rats (Rattus Norvegicus) Exposed with Cigarette Smoke Open
Large amounts of free radicals generate oxidative stress resulting in cell damage. Cigarettes are a source of exogenous free radicals containing various toxic substances. Cigarettes exposure decreased Leydig cells and testosterone. Cordyce…
View article: Avocado ( Persea americana Mill.) Seed Extract Cream 10% Inhibited The Increase MMP-12 Enzyme Levels And Elastosis In UVA Exposed Hairless Male Wistar Rats Skin
Avocado ( Persea americana Mill.) Seed Extract Cream 10% Inhibited The Increase MMP-12 Enzyme Levels And Elastosis In UVA Exposed Hairless Male Wistar Rats Skin Open
Background: Skin is the main target of environmental influences, especially chronic exposure to the suns UVA rays which will result in wrinkling, decreased skin elasticity, the appearance of loose skin, and a rough clinical appearance. In …
View article: The Administration of 15% Sensitive Plant (Mimosa pudica) Leaf Extract Cream Inhibited the Increasing of Tyrosinase Enzyme and the Amount of Melanin in Male Guinea Pig (Cavia porcellus) Skin Exposed to Ultraviolet B
The Administration of 15% Sensitive Plant (Mimosa pudica) Leaf Extract Cream Inhibited the Increasing of Tyrosinase Enzyme and the Amount of Melanin in Male Guinea Pig (Cavia porcellus) Skin Exposed to Ultraviolet B Open
Background: The leaf of sensitive plant (Mimosa pudica Linn) has a fairly high content of flavonoids, which work in inhibiting the tyrosinase enzyme. Changes in the formation of this enzyme will cause the melanin pigment to be disrupted, r…
View article: Study of Sericin Sequences from Bombyx mori as Antiaging through ROS with Molecular Simulation and DPPH Evaluation
Study of Sericin Sequences from Bombyx mori as Antiaging through ROS with Molecular Simulation and DPPH Evaluation Open
The presence of ROS is associated with aging, which is damage caused by free radical reactions. ROS causes oxidation of low density lipoprotein (LDL), which builds up in plaque and contributes to inflammation. With aldehyde secondary produ…
View article: The Ethanol Extract of Tangse Liberica Coffee (Coffea liberica) Inhibited the Reduction of Leydig Cell Number and Testosterone Levels in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Light
The Ethanol Extract of Tangse Liberica Coffee (Coffea liberica) Inhibited the Reduction of Leydig Cell Number and Testosterone Levels in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Light Open
Background: Aging is a complex mechanism related to various factors including free radicals. Free radicals that occur due to exposure to ultraviolet light can cause oxidative stress and damage the spermatogenesis process, including Leydig …
View article: Addition of 5% Saccharide Isomerates in Moisturizing Formulation Increases Skin Hydration Higher than Regular Moisturizers
Addition of 5% Saccharide Isomerates in Moisturizing Formulation Increases Skin Hydration Higher than Regular Moisturizers Open
Dry skin is a problem for millions of people and often causes discomfort and even psychological stress. Increasing the water content in the stratum corneum can be done by applying moisturizer regularly and regularly because it will improve…
View article: Addition of 5% Saccharide Isomerates in Moisturizing Formulation Increases Skin Hydration Higher than Regular Moisturizers
Addition of 5% Saccharide Isomerates in Moisturizing Formulation Increases Skin Hydration Higher than Regular Moisturizers Open
Dry skin is a problem for millions of people and often causes discomfort and even psychological stress. Increasing the water content in the stratum corneum can be done by applying moisturizer regularly and regularly because it will improve…
View article: Systematic Review of the Skin Photoaging and the Role of Sericin in its UV Protection
Systematic Review of the Skin Photoaging and the Role of Sericin in its UV Protection Open
View article: Intravenous Wharton's Jelly stem cell increased the number of ? cells pancreas and reduced the fasting blood glucose level in diabetes mellitus Wistar rat male (Rattus norvegicus)
Intravenous Wharton's Jelly stem cell increased the number of ? cells pancreas and reduced the fasting blood glucose level in diabetes mellitus Wistar rat male (Rattus norvegicus) Open
Introduction: Diabetes mellitus is a metabolic disease characterized by hyperglycemic and disorders of carbohydrate, protein and fat metabolism due to abnormalities in insulin secretion, insulin sensitivity or both. Based on previous resea…
View article: The administration of 3% Tamarind (Tamarindus indica) leaves ethanol extract cream inhibited the increase of tyrosinase expression and the amount of skin melanin in male Guinea pigs (Cavia porcellus) skin exposed to UV B
The administration of 3% Tamarind (Tamarindus indica) leaves ethanol extract cream inhibited the increase of tyrosinase expression and the amount of skin melanin in male Guinea pigs (Cavia porcellus) skin exposed to UV B Open
Background The main factor of skin aging is exposure to sunlight, especially UV B rays. Tamarind leaves extract is known to contain tannins, flavonoids, and polyphenols as anti- aging agents. This study was aimed to prove the protective ef…
View article: Administration of Myrmecodia pendans Ethanol Extract Cream Prevented Elevation of Keratinocyte Apoptosis and Number of Macrophages in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B (UVB)
Administration of Myrmecodia pendans Ethanol Extract Cream Prevented Elevation of Keratinocyte Apoptosis and Number of Macrophages in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B (UVB) Open
View article: Level of 25 (OH) Vitamin D Lower in Central Obesity Women Compared to Normal Weight Women and its Correlation with Blood Pressure
Level of 25 (OH) Vitamin D Lower in Central Obesity Women Compared to Normal Weight Women and its Correlation with Blood Pressure Open
View article: Allium Ascalonicum L. Ethanolic Extract Inhibited the Decrease of eNOS but did not Inhibit the Decrease of Spatial Memory in D-Galactose-Induced Balb/c Male Mice
Allium Ascalonicum L. Ethanolic Extract Inhibited the Decrease of eNOS but did not Inhibit the Decrease of Spatial Memory in D-Galactose-Induced Balb/c Male Mice Open
View article: The Administration of Zinc Inhibited the Decrease of Leydig Cell and Testosterone Level in Male Wistar Rats (Rattus Norvegicus) that are Exposed to Electric Cigarette Smoke
The Administration of Zinc Inhibited the Decrease of Leydig Cell and Testosterone Level in Male Wistar Rats (Rattus Norvegicus) that are Exposed to Electric Cigarette Smoke Open
View article: Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed Guinea pig (Cavia porcellus) skin
Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed Guinea pig (Cavia porcellus) skin Open
Background Excessive sun exposure results in increased activity of the tyrosinase enzyme and the amount of melanin in the skin which causes hyperpigmentation, a sign of premature aging. The purpose of this study was to prove that Ashitaba …
View article: Intradermal injection of umbilical cord mesenchymal stem cells was more effective than platelet rich plasma in increasing amount of collagen and fibroblasts in Wistar rats (Rattus norvegicus) back skin exposed to ultraviolet B rays
Intradermal injection of umbilical cord mesenchymal stem cells was more effective than platelet rich plasma in increasing amount of collagen and fibroblasts in Wistar rats (Rattus norvegicus) back skin exposed to ultraviolet B rays Open
Background Ultraviolet B exposure is one of the causes of extrinsic skin aging. Ultraviolet exposure may lead to skin collagen damage. This study about mesenchymal stem cells from umbilical cord (UCMSC) compared with platelet rich plasma (…