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View article: Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy
Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy Open
Hepatocellular carcinoma (HCC) is commonly classified as a “cold tumor” due to its low immunogenicity and poor response to conventional immunotherapies. Reprogramming the tumor immune microenvironment (TIME) via cuproptosis presents a prom…
View article: Microneedle Patch for In Situ Neutrophil Monitoring
Microneedle Patch for In Situ Neutrophil Monitoring Open
Monitoring neutrophil levels plays an essential role in diagnosing infections and various diseases, as well as for managing specific treatments such as chemotherapy and radiotherapy. However, the traditional complete blood count technique …
View article: Cachexia-related consequences of glycemic metabolism: A multivariable and two-step Mendelian randomization study
Cachexia-related consequences of glycemic metabolism: A multivariable and two-step Mendelian randomization study Open
Background: Cachexia is a global burden that is caused by chronic diseases such as cancer. It is characterized by inflammation and progressive loss of muscle and adipose tissue, aggravating the patient’s health. Glycemic metabolism disorde…
View article: Granulomas without foreign body giant cells in perianal fistula tissue suggest Crohn's disease
Granulomas without foreign body giant cells in perianal fistula tissue suggest Crohn's disease Open
Objectives Histopathological characteristics of granulomas in perianal fistula of patients with Crohn's disease (CD) remain unexplored. We aimed to assess the histopathological features of granulomas in perianal fistula in CD. Methods A re…
View article: Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy
Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy Open
Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as they avoid excessive inflammation and mediate tumor development. The abundance of Tregs in tumor tissues suggests that Tregs may be eliminated or …
View article: Adavosertib-encapsulated metal-organic frameworks for p53-mutated gallbladder cancer treatment via synthetic lethality
Adavosertib-encapsulated metal-organic frameworks for p53-mutated gallbladder cancer treatment via synthetic lethality Open
Adavosertib (ADA) is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer (GBC). However, drug resistance due to DNA damage response compensation pathways and high toxicity limits further applications.…
View article: Research progress and future prospects in glucose oxidase-like activity of Au NPs
Research progress and future prospects in glucose oxidase-like activity of Au NPs Open
With the advancement of scientific research, an increasing number of studies on metal nanozymes, particularly Au NPs, have been conducted. They possess glucose oxidase (GOD)-like activity and peroxidase (POD)-like activity, with GOD-like a…
View article: Erratum to “Research trends in cholangiocarcinoma treatments during the last 3 decades” [Heliyon 9(7) (July 2023) e17100]
Erratum to “Research trends in cholangiocarcinoma treatments during the last 3 decades” [Heliyon 9(7) (July 2023) e17100] Open
[This corrects the article DOI: 10.1016/j.heliyon.2023.e17100.].
View article: Estimating the influencing factors for T1b/<scp>T2</scp> gallbladder cancer on survival and surgical approaches selection
Estimating the influencing factors for T1b/<span>T2</span> gallbladder cancer on survival and surgical approaches selection Open
Background The influencing factors, especially time to treatment (TTT), for T1b/T2 gallbladder cancer (GBC) patients remain unknown. We aimed to identify the influencing factors on survival and surgical approaches selection for T1b/T2 GBC.…
View article: Applications of Artificial Intelligence Based on Medical Imaging in Glioma: Current State and Future Challenges
Applications of Artificial Intelligence Based on Medical Imaging in Glioma: Current State and Future Challenges Open
Glioma is one of the most fatal primary brain tumors, and it is well-known for its difficulty in diagnosis and management. Medical imaging techniques such as magnetic resonance imaging (MRI), positron emission tomography (PET), and spectra…
View article: Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth
Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth Open
Background Penfluridol (PF) is an FDA-approved antipsychotic drug that has recently been shown to have anticancer activity. However, the anticancer effects and underlying mechanisms of PF are not well-established in gallbladder cancer (GBC…
View article: Identification of invasion-metastasis associated MiRNAs in gallbladder cancer by bioinformatics and experimental validation
Identification of invasion-metastasis associated MiRNAs in gallbladder cancer by bioinformatics and experimental validation Open
Background Recent studies exploring the roles of invasion-metastasis associated miRNAs in gallbladder cancer (GBC) are limited. In the study, we aimed to identify the invasion-metastasis associated miRNAs in GBC by bioinformatics and exper…
View article: Enhanced Recovery Care vs. Traditional Care in Laparoscopic Hepatectomy: A Systematic Review and Meta-Analysis
Enhanced Recovery Care vs. Traditional Care in Laparoscopic Hepatectomy: A Systematic Review and Meta-Analysis Open
Background Enhanced recovery care could alleviate surgical stress and accelerate the recovery rates of patients. Previous studies showed the benefits of enhanced recovery after surgery program in liver surgery, but the exact role in laparo…
View article: DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions
DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions Open
DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage. While DDR promotes genomic stability in no…
View article: Inhibition of AMPK/PFKFB3 Mediated Glycolysis Synergizes with Penfluridol to Suppress Gallbladder Cancer Growth
Inhibition of AMPK/PFKFB3 Mediated Glycolysis Synergizes with Penfluridol to Suppress Gallbladder Cancer Growth Open
Background Penfluridol (PF) is an FDA approved antipsychotic drug, which shows anticancer activity recently. However, the anticancer effects and underlying mechanisms of PF on gallbladder cancers (GBCs) is not well-established. Methods Her…
View article: Comparison of Outcomes After Primary Laparoscopic Versus Open Approach for T1b/T2 Gallbladder Cancer
Comparison of Outcomes After Primary Laparoscopic Versus Open Approach for T1b/T2 Gallbladder Cancer Open
Objectives The primary laparoscopic approach (PLA) for T1b/T2 gallbladder cancer (GBC) remains contradicted. We aimed to compare the perioperative and long-term outcomes after PLA versus open approach (OA) for T1b/T2 GBC. Methods Patients …
View article: Artificial intelligence in gastroenterology and hepatology: Status and challenges
Artificial intelligence in gastroenterology and hepatology: Status and challenges Open
Originally proposed by John McCarthy in 1955, artificial intelligence (AI) has achieved a breakthrough and revolutionized the processing methods of clinical medicine with the increasing workloads of medical records and digital images. Doct…
View article: Development and Validation of a Nomogram for Predicting Survival in Gallbladder Cancer Patients With Recurrence After Surgery
Development and Validation of a Nomogram for Predicting Survival in Gallbladder Cancer Patients With Recurrence After Surgery Open
Background The management of gallbladder cancer (GBC) patients with recurrence who need additional therapy or intensive follow-up remains controversial. Therefore, we aim to develop a nomogram to predict survival in GBC patients with recur…
View article: Supplementary Material for: Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma
Supplementary Material for: Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma Open
Background: The preoperative selection of patients with intermediate-stage hepatocellular carcinoma (HCC) who are likely to have an objective response to first transarterial chemoembolization (TACE) remains challenging. Objective: To devel…
View article: Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma
Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma Open
Background: The preoperative selection of patients with intermediate-stage hepatocellular carcinoma (HCC) who are likely to have an objective response to first transarterial chemoembolization (TACE) remains challenging. Objective: To devel…
View article: Development of synthetic lethality in cancer: molecular and cellular classification
Development of synthetic lethality in cancer: molecular and cellular classification Open
Recently, genetically targeted cancer therapies have been a topic of great interest. Synthetic lethality provides a new approach for the treatment of mutated genes that were previously considered unable to be targeted in traditional genoty…
View article: Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients
Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients Open
Objective: To assess the value of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) during acute phase in predicting post-stroke cognitive impairment (PSCI) at 3-6 months. Methods: We prospectively recru…
View article: Laparoscopic surgery for early gallbladder carcinoma: A systematic review and meta-analysis
Laparoscopic surgery for early gallbladder carcinoma: A systematic review and meta-analysis Open
This systematic review and meta-analysis confirms that laparoscopic surgery is a safe and feasible alternative to open surgery with comparable survival and operation-related outcomes for early GBC.
View article: Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma
Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma Open
FHR and Barcelona Clinic Liver Cancer stages were regarded as prognostic factors for OS. Moreover, high FHR and the absence of MVI were important predictive factors, which can be used to assist clinicians in selecting which patients could …