Explanipedia

Organ Procurement Organization Approach of ICU Families in Person Versus by Phone for Donation Authorization Open

Qiang Zhang, Brandon McKown, Winnie Lau, Tamara Strohm, Lisa A. Paolillo , et al. · 2025

OBJECTIVES: Due to hospital visitor restriction policies, the COVID-19 pandemic forced many conversations between ICU patients’ families and organ procurement organizations (OPOs) to be conducted by phone, as opposed to in-person. We aimed…

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle Open

Carys Johnson, Matthew Williams, Kendig Sham, Serena Belluschi, Wenjuan Ma , et al. · 2024

Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain incompletely characterized. In this s…

Enhanced recovery in patients with gestational diabetes mellitus and MTHFR 677 TT genotype after taking high-dose folic acid supplements during mid-late pregnancy: an open-label interventional study Open

Binwu Ying, Jie Zhang, Piyu Li, Lu Liu, Yan Li , et al. · 2023

Objective To explore the relationship between folic acid supplementation and the recovery rate of gestational diabetes mellitus (GDM) in women with methylenetetrahydrofolate ( MTHFR ) 677 TT genotypes in mid-late pregnancy. Methods 9, 096 …

Curriculum Innovations: A Podcast-Based Neurologic Emergency Flipped Classroom Curriculum for Neurology Residents Open

Jeffrey Ratliff, Fábio A. Nascimento, Leticia Tornes, Jason Margolesky, Matthew Feldman , et al. · 2023

We present a 3-part curriculum to help build learners' familiarity and confidence in 3 neurologic emergency categories. The educational impact is established in Level 1 of the Kirkpatrick paradigm. Future studies can explore a higher-level…

Reply Open

Paul T. Finger, Ankit Singh Tomar, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2022

Adaptation to<i>ex vivo</i>culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner Open

Carys Johnson, Kendig Sham, Serena Belluschi, Xiaonan Wang, Winnie Lau , et al. · 2022

Loss of long-term haematopoietic stem cell function (LT-HSC) hampers the success of ex vivo HSC gene therapy and expansion procedures, but the kinetics and the mechanisms by which this occurs remain incompletely characterized. Here through…

Medical management of cerebral edema in large hemispheric infarcts Open

Grace DeHoff, Winnie Lau · 2022

Acute ischemic stroke confers a high burden of morbidity and mortality globally. Occlusion of large vessels of the anterior circulation, namely the intracranial carotid artery and middle cerebral artery, can result in large hemispheric str…

Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda L. Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2022

High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2022

The association of garlic intake and cardiovascular risk factors: A systematic review and meta-analysis Open

Sha Li, Wei Guo, Winnie Lau, Hui Zhang, Zhong‐Qun Zhan , et al. · 2022

Garlic is a common cooking ingredient and used in traditional medicine in Asian countries. There is a growing attention on garlic due to its preventive characteristics in cardiovascular diseases (CVDs). Many studies have reviewed the assoc…

The association of garlic intake and cardiovascular risk factors: A systematic review and meta-analysis Open

Sha Li, Wei Guo, Winnie Lau, Hui Zhang, Zhong‐Qun Zhan , et al. · 2022

Garlic is a common cooking ingredient and used in traditional medicine in Asian countries. There is a growing attention on garlic due to its preventive characteristics in cardiovascular diseases (CVDs). Many studies have reviewed the assoc…

Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization Open

Pawel Roszak, Jung‐ok Heo, Bernhard Blob, Koichi Toyokura, Yuki Sugiyama , et al. · 2021

Root meristem controls The plant meristem, a small cluster of stem cells generates all of the cell types necessary for the plant’s indeterminate growth pattern. Roszak et al . use single-cell analyses to follow development from the stem ce…

Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging Open

Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2021

Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data w…

Frequency of Withdrawal of Life-Sustaining Therapy for Perceived Poor Neurologic Prognosis Open

Alexis Steinberg, Benjamin S. Abella, Emily J. Gilmore, David Y. Hwang, Niki R. Kennedy , et al. · 2021

OBJECTIVES: To measure the frequency of withdrawal of life-sustaining therapy for perceived poor neurologic prognosis among decedents in hospitals of different sizes and teaching statuses. DESIGN: We performed a multicenter, retrospective …

Utility of a safety switch to abrogate CD19.CAR T-cell–associated neurotoxicity Open

Matthew C. Foster, Barbara Savoldo, Winnie Lau, Clio Rubiños, Natalie S. Grover , et al. · 2021

2][3][4] Despite durable objective responses, most patients experience acute toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). 5Although many cases of ICANS resolve with …

Single‐cell molecular profiling provides a high‐resolution map of basophil and mast cell development Open

Fiona Hamey, Winnie Lau, Iwo Kuciński, Xiaonan Wang, Evangelia Diamanti , et al. · 2020

Background Basophils and mast cells contribute to the development of allergic reactions. Whereas these mature effector cells are extensively studied, the differentiation trajectories from hematopoietic progenitors to basophils and mast cel…

Global Retinoblastoma Treatment Outcomes Open

Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2020

This international, multicenter, registry-based analysis of retinoblastoma management revealed that lower national income levels were associated with significantly higher rates of metastasis-related mortality, local treatment failure, and …

A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Ashwin Mallipatna, Tero Kivelä , et al. · 2020

Multicenter, international, internet-based data sharing validated the 8th edition AJCC RB staging to predict globe-salvage in a large, heterogeneous, real-world patient population with RB.

A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda L. Gallie, Ashwin Mallipatna, Tero Kivelä , et al. · 2020

Single-cell molecular profiling provides a high-resolution map of basophil and mast cell differentiation Open

Fiona Hamey, Winnie Lau, Iwo Kuciński, Xiaonan Wang, Evangelia Diamanti , et al. · 2019

Differentiation of hematopoietic stem and progenitor cells ensure a continuous supply of mature blood cells. Recent models of differentiation are represented as a landscape, in which individual progenitors traverse a continuum of multipote…

Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool Open

Nicole Prior, Christopher J. Hindley, Fabian Rost, E. Meléndez, Winnie Lau , et al. · 2019

During mouse embryogenesis, progenitors within the liver known as hepatoblasts give rise to adult hepatocytes and cholangiocytes. Hepatoblasts, which are specified at E8.5-E9.0, have been regarded as a homogeneous progenitor population tha…

Lgr5+ stem/progenitor cells reside at the apex of the embryonic hepatoblast pool Open

Nicole Prior, Christopher J. Hindley, Fabian Rost, E Esteban, Winnie Lau , et al. · 2018

During mouse embryogenesis, progenitors within the liver known as hepatoblasts give rise to adult hepatocyte and cholangiocyte cells. Hepatoblasts, which are specified at E8.5-E9.0, have been regarded as a homogeneous population of progeni…

Late diagnosis of a rare urea cycle disorder mimicking Kleine-Levin syndrome Open

Nina Bozinov, Michelle Han, Winnie Lau, Veronica Santini · 2018

Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodic hypersomnia, cognitive changes, and neuropsychiatric symptoms between months of interictal normality (table). Triggers include infection, sleep deprivation,…

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors Open

Serena Belluschi, Emily F. Calderbank, Valerio Ciaurro, Blanca Pijuan-Sala, Antonella Santoro , et al. · 2018

T cell cytolytic capacity is independent of initial stimulation strength Open

Arianne C. Richard, Aaron T. L. Lun, Winnie Lau, Berthold Göttgens, John C. Marioni , et al. · 2018

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice Open

Joakim S. Dahlin, Fiona Hamey, Blanca Pijuan-Sala, Mairi Shepherd, Winnie Lau , et al. · 2018

Key Points Single-cell transcriptional landscape of 44 802 hematopoietic stem/progenitor cells defines entry points to 8 different blood lineages. Comparison with 13 815 c-Kit mutant cells identifies pleiotropic changes in cell type abunda…

Botulinum toxin as an initial therapy for management of sixth nerve palsies caused by nasopharyngeal carcinomas Open

E S Wong, Carol P. Lam, F H S Lau, Winnie Lau, Jason C. Yam · 2018

C4 Nephritic Factors in C3 Glomerulopathy: A Case Series Open

Yuzhou Zhang, Nicole C. Meyer, Fernando C. Fervenza, Winnie Lau, Adam Keenan , et al. · 2017

The finding of C4NeFs in a small percentage of patients with C3G highlights the challenge in identifying autoantibodies that drive complement dysregulation and underscores the complexity of the autoantibody repertoire that can be identifie…

Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis Open

Shu Min Tang, Rachel Y. T. Chan, Shi Bin Lin, Shi Song Rong, Henry H. W. Lau , et al. · 2016

This systematic review and meta-analysis is to evaluate the risk of development of concomitant strabismus due to refractive errors. Eligible studies published from 1946 to April 1, 2016 were identified from MEDLINE and EMBASE that evaluate…

Risk of recurrence of retinopathy of prematurity after initial intravitreal ranibizumab therapy Open

Joyce Chan, Carol P. Lam, Madeline K. M. Kwok, Raymond Wong, Gary K. Y. Lee , et al. · 2016

We report our experience with the use of intravitreal ranibizumab for the treatment of retinopathy of prematurity (ROP). A retrospective review was performed on 138 consecutive infants screened at a single centre over 18 months. Intravitre…

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