Wing Leung
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View article: HLA-vaccine transplantations for refractory leukemia: beyond double-unit cord blood
HLA-vaccine transplantations for refractory leukemia: beyond double-unit cord blood Open
Recent studies in double-unit cord blood transplantation have shown that when the patient (PT) and the losing unit (LU) share an HLA determinant mismatched against the winning unit (WU), leukemia relapse risk declines without added graft-v…
View article: HLA vaccine effect in double cord blood transplant: a Chinese cohort
HLA vaccine effect in double cord blood transplant: a Chinese cohort Open
View article: Vibration-Based Detection for the Monitoring of Neonatal bCPAP Respiratory Support to Minimize Duration of Disconnections
Vibration-Based Detection for the Monitoring of Neonatal bCPAP Respiratory Support to Minimize Duration of Disconnections Open
Bubble continuous positive airway pressure (bCPAP) is a minimally invasive respiratory support for neonates experiencing respiratory distress syndrome (RDS). It exerts continuous, oscillatory air pressure to encourage lung function and dev…
View article: 184 | GENOMIC PROFILING OF EXTRANODAL DISEASE IN PATIENTS WITH DIFFUSE LARGE B‐CELL LYMPHOMA: A COMBINED ANALYSIS OF POLARIX AND GOYA
184 | GENOMIC PROFILING OF EXTRANODAL DISEASE IN PATIENTS WITH DIFFUSE LARGE B‐CELL LYMPHOMA: A COMBINED ANALYSIS OF POLARIX AND GOYA Open
View article: Living with cystic fibrosis during the COVID-19 pandemic: An interpretive description of healthcare access from patients with cystic fibrosis and their providers in Alberta, Canada
Living with cystic fibrosis during the COVID-19 pandemic: An interpretive description of healthcare access from patients with cystic fibrosis and their providers in Alberta, Canada Open
Background The current study aimed to explore patient and provider perspectives of the impact of the pandemic on cystic fibrosis healthcare access and service delivery. Methods We used Interpretive Description, a qualitative approach with …
View article: Adapting selected international paediatric asthma guidelines for use in Hong Kong
Adapting selected international paediatric asthma guidelines for use in Hong Kong Open
View article: Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy
Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy Open
Despite promising results with chimeric antigen receptor modified T(CAR-T) cells and virus-specific T(VST) cells, both forms of therapy are limited by timely availability, affordability, in vivo persistency, and antigen escape. To o…
View article: The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis
The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis Open
Introduction Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myoc…
View article: 119 Auto-imaging cytometry on the slide (ICOS) for quality control of CAR-T products
119 Auto-imaging cytometry on the slide (ICOS) for quality control of CAR-T products Open
View article: COVID-19-related organising pneumonia in patients with secondary antibody deficiency responds to immunoglobulin
COVID-19-related organising pneumonia in patients with secondary antibody deficiency responds to immunoglobulin Open
COVID-19-related organising pneumonia may not respond to antivirals and corticosteroids in patients with secondary antibody deficiency. Immunoglobulin replacement resulted in rapid clinical improvement in this case series of four such p…
View article: High infection rates and risk‐adapted prevention strategies in contemporary pediatric allogeneic hematopoietic stem cell transplantation
High infection rates and risk‐adapted prevention strategies in contemporary pediatric allogeneic hematopoietic stem cell transplantation Open
With recent changes in hematopoietic stem cell transplantation (HSCT) practices, such as the increasing use of alternative donors and ex vivo T‐cell depletion, how various risk factors interplay and affect the timeline of infections have n…
View article: Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial
Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial Open
View article: The central role of natural killer cells in mediating acute myocarditis after mRNA COVID-19 vaccination
The central role of natural killer cells in mediating acute myocarditis after mRNA COVID-19 vaccination Open
View article: Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware
Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware Open
This study introduces two models, ConvLSTM2D-liquid time-constant network (CLTC) and ConvLSTM2D-closed-form continuous-time neural network (CCfC), designed for abnormality identification using electrocardiogram (ECG) data. Trained on the T…
View article: On-device edge-learning for cardiac abnormality detection using a bio-inspired and spiking shallow network
On-device edge-learning for cardiac abnormality detection using a bio-inspired and spiking shallow network Open
This work presents an on-device edge-learning for cardiac abnormality detection by developing a hybrid and spiking form of 2-Dimensional (time-frequency) Convolutional Long-Short-Term Memory (ConvLSTM2D) with Closed-form Continuous-time (C…
View article: No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma
No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma Open
View article: Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware
Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware Open
This study introduces two models, CLTC and CCfC, designed for abnormality identification using ECG data. Trained on the TNMG subset dataset, both models were evaluated for their performance, generative capacity, and resilience. They demons…
View article: Tumor vaccine based on extracellular vesicles derived from γδ‐T cells exerts dual antitumor activities
Tumor vaccine based on extracellular vesicles derived from γδ‐T cells exerts dual antitumor activities Open
γδ‐T cells are innate‐like T cells with dual antitumor activities. They can directly eradicate tumor cells and function as immunostimulatory cells to promote antitumor immunity. Previous studies have demonstrated that small extracellular v…
View article: Editorial: Translating NK cell scientific research to clinical product manufacturing
Editorial: Translating NK cell scientific research to clinical product manufacturing Open
EDITORIAL article Front. Immunol., 23 August 2023Sec. NK and Innate Lymphoid Cell Biology Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1229417
View article: Analysis of immune and high‐risk biomarkers in patients with relapsed or refractory mantle cell lymphoma treated with glofitamab monotherapy
Analysis of immune and high‐risk biomarkers in patients with relapsed or refractory mantle cell lymphoma treated with glofitamab monotherapy Open
Introduction: Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma with no recognized standard of care in the relapsed or refractory (R/R) setting. Glofitamab is a CD20xCD3 T-cell-engaging bispecific antibody with a nove…
View article: BCMA CAR-T induces complete and durable remission in refractory plasmablastic lymphoma
BCMA CAR-T induces complete and durable remission in refractory plasmablastic lymphoma Open
Plasmablastic lymphoma (PBL) is a rare subtype of aggressive large B-cell lymphoma, with a dismal prognosis despite aggressive therapies. New approaches are needed for those with refractory disease. PBL expresses antigens similar to multip…
View article: Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Open
Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
View article: Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Open
Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
View article: Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Open
Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
View article: Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Open
Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging due to inherent differences in underlying genetics. Here we established the pharmacologic …
View article: Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Open
Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
View article: Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Open
Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging due to inherent differences in underlying genetics. Here we established the pharmacologic …
View article: Supplementary Figure 2 from Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NK Cell Resistance in <i>MLL</i>-Rearranged Leukemia Expressing Inhibitory KIR Ligands but Not Activating Ligands
Supplementary Figure 2 from Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NK Cell Resistance in <i>MLL</i>-Rearranged Leukemia Expressing Inhibitory KIR Ligands but Not Activating Ligands Open
PDF file - 100K, Characterization of luciferase+ mutant SEM cells. The susceptibility of luciferase+ mutant cell-line to ADCC induced by (A) XmAb5574 or (B) lintuzumab was not changed. (C) Determination of linear range of bioluminescence f…
View article: Supplementary Figure Legend from Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NK Cell Resistance in <i>MLL</i>-Rearranged Leukemia Expressing Inhibitory KIR Ligands but Not Activating Ligands
Supplementary Figure Legend from Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NK Cell Resistance in <i>MLL</i>-Rearranged Leukemia Expressing Inhibitory KIR Ligands but Not Activating Ligands Open
PDF file - 65K
View article: Table S4 from Memory T Cells Expressing an NKG2D-CAR Efficiently Target Osteosarcoma Cells
Table S4 from Memory T Cells Expressing an NKG2D-CAR Efficiently Target Osteosarcoma Cells Open
Liver enzymes measured in NKG2D-CAR treated and control mice.