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View article: The association between reproductive hormones and asthma-related outcomes in boys in the rural Western Cape Province, South Africa
The association between reproductive hormones and asthma-related outcomes in boys in the rural Western Cape Province, South Africa Open
Background. Asthma is more prevalent and severe among boys than girls, but this pattern reverses after puberty. It has been suggested that reproductive hormones may play a role in explaining these sex differences after puberty. However, th…
View article: Scalp haircuts, keloids and blood-borne virus transmission risk in South Africa—The SHAKA study
Scalp haircuts, keloids and blood-borne virus transmission risk in South Africa—The SHAKA study Open
Background The most frequent transmission modes of blood-borne infections (BBI), including HIV, hepatitis B virus (HBV) and C (HCV), are well documented. South Africa, an HIV epicentre, with HBV endemicity and an additional HCV burden, rai…
View article: Assessing the preparedness of primary healthcare facilities for the implementation of universal test and treat in uThukela District, South Africa: a cross-sectional study
Assessing the preparedness of primary healthcare facilities for the implementation of universal test and treat in uThukela District, South Africa: a cross-sectional study Open
Background The availability of HIV guidelines, infrastructure, essential medicines and diagnostic tests for HIV services is a prerequisite to effective universal test-and-treat (UTT) services. However, evidence on public facility readiness…
View article: Assessing PrEP Initiation and Adherence Among High-Risk, Sexually Active Adolescents and Young Adults: A Population-Based Prospective Study Across Diverse Service Delivery Models in a High HIV Prevalent District in South Africa
Assessing PrEP Initiation and Adherence Among High-Risk, Sexually Active Adolescents and Young Adults: A Population-Based Prospective Study Across Diverse Service Delivery Models in a High HIV Prevalent District in South Africa Open
Pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy for high-risk populations, including adolescent girls and young women (AGYW) and adolescent boys and young men (ABYM). While various PrEP-delivery models exist in Sout…
View article: Diagnostic utility of lung ultrasound in preterm neonates with respiratory distress at a tertiary neonatal intensive care unit in South Africa
Diagnostic utility of lung ultrasound in preterm neonates with respiratory distress at a tertiary neonatal intensive care unit in South Africa Open
Background. Accumulating data suggest the potential for lung ultrasound (LUS) to diagnose pathology in preterm babies, but there are no published data from South Africa (SA). Objectives. To describe LUS diagnoses, respiratory pathology and…
View article: Alcohol restrictions and suicide rates in South Africa during the COVID-19 pandemic: results of a natural experiment
Alcohol restrictions and suicide rates in South Africa during the COVID-19 pandemic: results of a natural experiment Open
Background Alcohol use is a well-established potentially modifiable risk factor for suicide, yet few studies have investigated the impact of alcohol restrictions on suicide rates, particularly in low- and middle-income countries. Methods W…
View article: Linkage to HIV care and early retention in HIV care among men in the ‘universal test-and-treat’ era in a high HIV-burdened district, KwaZulu-Natal, South Africa
Linkage to HIV care and early retention in HIV care among men in the ‘universal test-and-treat’ era in a high HIV-burdened district, KwaZulu-Natal, South Africa Open
Introduction Despite the numerous efforts and initiatives, males with HIV are still less likely than women to receive HIV treatment. Across Sub-Saharan Africa, men are tested, linked, and retained in HIV care at lower rates than women, and…
View article: Vaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination: The ZIMGARD Cohort
Vaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination: The ZIMGARD Cohort Open
Background: Human papillomavirus (HPV) vaccination programs are a key intervention in protecting individuals against HPV-related disease. HIV1-infected individuals are at increased risk of HPV-associated cancers. This study was conducted t…
View article: A descriptive study of vancomycin use at Red Cross War Memorial Children’s Hospital, Cape Town
A descriptive study of vancomycin use at Red Cross War Memorial Children’s Hospital, Cape Town Open
The study identified multiple opportunities for improved vancomycin prescribing and monitoring. Further research and implementation of improved prescribing practices could contribute to the preservation of vancomycin as an effective antibi…
View article: Low incidence of pulmonary hypertension in children with suspected obstructive sleep apnea: A prospective observational study
Low incidence of pulmonary hypertension in children with suspected obstructive sleep apnea: A prospective observational study Open
PH is uncommon in children with uncomplicated OSA and there is no association of PH with severity of OSA measured by OO. Routine echocardiographic screening for PH in children with clinical symptoms of OSA without co-morbidity is unwarrant…
View article: Enhancing linkage to HIV care in the “Universal Test-and-Treat” era: Barriers and enablers to HIV care among adults in a high HIV burdened district in KwaZulu-Natal, South Africa
Enhancing linkage to HIV care in the “Universal Test-and-Treat” era: Barriers and enablers to HIV care among adults in a high HIV burdened district in KwaZulu-Natal, South Africa Open
Ending AIDS by 2030 would depend on how successful health systems are in linking people living with HIV (PLHIV) into care. The World Health Organization recommended the ‘Universal Test-and-Treat’ (UTT) strategy – initiating all individuals…
View article: Healthcare provider perceptions on the implementation of the universal test-and-treat policy in South Africa: a qualitative inquiry
Healthcare provider perceptions on the implementation of the universal test-and-treat policy in South Africa: a qualitative inquiry Open
Background South Africa had an estimated 7.5 million people living with HIV (PLHIV), accounting for approximately 20% of the 38.4 million PLHIV globally in 2021. In 2015, the World Health Organization recommended the universal test and tre…
View article: Service delivery models that promote linkages to PrEP for adolescent girls and young women and men in sub-Saharan Africa: a scoping review
Service delivery models that promote linkages to PrEP for adolescent girls and young women and men in sub-Saharan Africa: a scoping review Open
Background Pre-exposure prophylaxis (PrEP) is an emerging biomedical prevention intervention. Documenting PrEP service delivery models (SDMs) that promote linkage to and continuation of PrEP will inform guidelines and maximise roll-out. Ob…
View article: Strengthening health system’s capacity for linkage to HIV care for adolescent girls and young women and adolescent boys and young men in South Africa (SheS’Cap-Linkage): Protocol for a mixed methods study in KwaZulu-Natal, South Africa
Strengthening health system’s capacity for linkage to HIV care for adolescent girls and young women and adolescent boys and young men in South Africa (SheS’Cap-Linkage): Protocol for a mixed methods study in KwaZulu-Natal, South Africa Open
Introduction Adolescent girls and young women (AGYW) aged 15–24 years and adolescent boys and young men (ABYM) aged 15–34 years represent one of the populations at highest risk for HIV-infection in South Africa. The National Department of …
Candida bloodstream infection among children hospitalised in three public-sector hospitals in the Metro West region of Cape Town, South Africa Open
Background Candida bloodstream infection (BSI) causes appreciable mortality in neonates and children. There are few studies describing the epidemiology of Candida BSI in children living in sub-Saharan Africa. Methods A retrospective descri…
View article: Candida bloodstream infection among children hospitalised in three public- sector hospitals in the Metro West region of Cape Town, South Africa
Candida bloodstream infection among children hospitalised in three public- sector hospitals in the Metro West region of Cape Town, South Africa Open
Background Candida bloodstream infection (BSI) causes appreciable mortality in neonates and children. There are few studies describing the epidemiology of Candida BSI in children living in sub-Saharan Africa. Methods A retrospective descri…
View article: Barriers and Facilitating Factors to HIV Treatment Among Men in a High-HIV-Burdened District in KwaZulu-Natal, South Africa: A Qualitative Study
Barriers and Facilitating Factors to HIV Treatment Among Men in a High-HIV-Burdened District in KwaZulu-Natal, South Africa: A Qualitative Study Open
Despite enormous increases in the proportion of people living with HIV accessing treatment in sub-Saharan Africa, major gender disparities persist, with men experiencing lower rates of testing, linkage to treatment, and retention in care. …
View article: Service delivery models for enhancing linkage to and retention in HIV care services for adolescent girls and young women and adolescent boys and young men: a protocol for an overview of systematic reviews
Service delivery models for enhancing linkage to and retention in HIV care services for adolescent girls and young women and adolescent boys and young men: a protocol for an overview of systematic reviews Open
Introduction Recent advances in the HIV care continuum have shown that an individual diagnosed with HIV should be initiated on antiretroviral therapy as soon as possible regardless of the CD4 count levels and retained in HIV care services.…
View article: Healthcare provider perceptions on the implementation of the Universal Test-and-Treat policy in South Africa: A qualitative inquiry
Healthcare provider perceptions on the implementation of the Universal Test-and-Treat policy in South Africa: A qualitative inquiry Open
Background The number of people living with HIV (PLHIV) in South Africa was estimated at 7.1 million, accounting for approximately 20% of the 36.9 million PLHIV globally in 2017. In 2015, the World Health Organization (WHO) recommended the…
View article: Strengthening Health System’s Capacity for Linkage to HIV Care for adolescent girls and young women and adolescent boys and young men in South Africa (SheS’Cap-Linkage): Protocol for a mixed methods study in KwaZulu-Natal, South Africa
Strengthening Health System’s Capacity for Linkage to HIV Care for adolescent girls and young women and adolescent boys and young men in South Africa (SheS’Cap-Linkage): Protocol for a mixed methods study in KwaZulu-Natal, South Africa Open
Introduction In South Africa, HIV prevalence among adolescent girls and young women (AGYW) was 5.8% (15-19 years) and 15.6% (20-24 years) respectively in 2017. Amongst South African males, HIV prevalence in 2017 was 4.7% (15-19 years), 4.8…
View article: Strengthening health system’s capacity for pre-exposure prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS’Cap–PrEP): Protocol for a mixed methods study in KwaZulu-Natal, South Africa
Strengthening health system’s capacity for pre-exposure prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS’Cap–PrEP): Protocol for a mixed methods study in KwaZulu-Natal, South Africa Open
Introduction Pre-exposure prophylaxis (PrEP) is an effective prevention intervention that can be used to control HIV incidence especially among people who are at increased risk for HIV such as adolescent girls and young women (AGYW) and ad…
View article: Linkage to HIV care and early retention in care rates in the Universal Test-and-Treat era: a population-based prospective study in KwaZulu-Natal, South Africa
Linkage to HIV care and early retention in care rates in the Universal Test-and-Treat era: a population-based prospective study in KwaZulu-Natal, South Africa Open
Introduction: HIV care, linkage, and retention are key weaknesses in South Africa’s national antiretroviral therapy (ART) program, with the greatest loss of patients in the HIV treatment pathway occurring before ART initiation. Very few st…
View article: Strengthening health system’s capacity for pre-exposure Prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS’Cap – PrEP): Protocol for a mixed methods study in KwaZulu-Natal, South Africa
Strengthening health system’s capacity for pre-exposure Prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS’Cap – PrEP): Protocol for a mixed methods study in KwaZulu-Natal, South Africa Open
Introduction Pre-exposure prophylaxis (PrEP) is an effective prevention intervention that can be used to control HIV incidence especially among people who are at increased risk for HIV such as adolescent girls and young women (AGYW) and ad…
View article: Environment‐dependent alterations of immune mediators in urban and rural South African children with atopic dermatitis
Environment‐dependent alterations of immune mediators in urban and rural South African children with atopic dermatitis Open
Background In order to improve targeted therapeutic approaches for children with atopic dermatitis (AD), novel insights into the molecular mechanisms and environmental exposures that differentially contribute to disease phenotypes are requ…