Wojciech G. Lesniak
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View article: In-bore MRI-compatible transrectal ultrasound and photoacoustic imaging
In-bore MRI-compatible transrectal ultrasound and photoacoustic imaging Open
View article: Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson’s disease severity
Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson’s disease severity Open
BACKGROUNDMicroglia-mediated brain immune changes play a role in the pathogenesis of Parkinson's disease (PD), but imaging microglia in living people with PD has relied on positron emission tomography (PET) ligands that lack specificity in…
View article: Cortical α4β2-nicotinic acetylcholine receptors and cognitive decline in Parkinson's disease
Cortical α4β2-nicotinic acetylcholine receptors and cognitive decline in Parkinson's disease Open
Background Autopsy and in vivo molecular imaging studies suggest altered binding of the α4β2-nicotinic cholinergic receptor (α4β2-nAChR) with cognitive dysfunction in Parkinson's disease (PD). Objective To determine the relationship betwee…
View article: Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis Open
Importance Studies using human postmortem tissue and imaging with positron emission tomography (PET) support a low hippocampal availability of the α7 nicotinic acetylcholine receptor (α7-nAChR) in psychotic conditions, particularly in schi…
View article: Multimodal, PSMA-Targeted, PAMAM Dendrimer-Drug Conjugates for Treatment of Prostate Cancer: Preclinical Evaluation
Multimodal, PSMA-Targeted, PAMAM Dendrimer-Drug Conjugates for Treatment of Prostate Cancer: Preclinical Evaluation Open
In this study, we synthesized a multimodal theranostic agent capable of delivering DM1 and a radionuclide to PSMA+ tumors. This approach holds promise for enhancing image-guided treatment of aggressive, metastatic subtypes of pr…
View article: PET-MR Guided, Pre-targeted delivery to HER2(+) Breast Cancer Model
PET-MR Guided, Pre-targeted delivery to HER2(+) Breast Cancer Model Open
View article: Beyond synthetic aperture focusing: deconvolution-based elevation resolution enhancement using simulated point spread function for linear array-based three-dimensional photoacoustic imaging
Beyond synthetic aperture focusing: deconvolution-based elevation resolution enhancement using simulated point spread function for linear array-based three-dimensional photoacoustic imaging Open
This paper introduces a deconvolution-based method to enhance the elevation resolution of a linear array-based three-dimensional (3D) photoacoustic (PA) imaging system. PA imaging combines the high contrast of optical imaging with the deep…
View article: Beyond Synthetic Aperture Focusing: Deconvolution-Based Elevation Resolution Enhancement Using Simulated Point Spread Function for Linear Array-Based Three-dimensional Photoacoustic Imaging
Beyond Synthetic Aperture Focusing: Deconvolution-Based Elevation Resolution Enhancement Using Simulated Point Spread Function for Linear Array-Based Three-dimensional Photoacoustic Imaging Open
This paper introduces a deconvolution-based method to enhance the elevation resolution of a linear array-based three-dimensional (3D) photoacoustic (PA) imaging system. PA imaging combines the high contrast of optical imaging and the high …
View article: Beyond Synthetic Aperture Focusing: Deconvolution-Based Elevation Resolution Enhancement Using Simulated Point Spread Function for Linear Array-Based Three-dimensional Photoacoustic Imaging
Beyond Synthetic Aperture Focusing: Deconvolution-Based Elevation Resolution Enhancement Using Simulated Point Spread Function for Linear Array-Based Three-dimensional Photoacoustic Imaging Open
This paper introduces a deconvolution-based method to enhance the elevation resolution of a linear array-based three-dimensional (3D) photoacoustic (PA) imaging system. PA imaging combines the high contrast of optical imaging and the high …
View article: In-bore MRI-compatible Transrectal Ultrasound and Photoacoustic Imaging
In-bore MRI-compatible Transrectal Ultrasound and Photoacoustic Imaging Open
Prostate cancer (PCa) is known as one of the most prevalent and fatal cancer types. This report describes an MRI-compatible photoacoustic/ultrasound (PA/US) imaging platform to improve the diagnosis of PCa. In the proposed solution, PA ima…
View article: Imaging Brain Injury in Former National Football League Players
Imaging Brain Injury in Former National Football League Players Open
Importance Pilot studies that involved early imaging of the 18 kDa translocator protein (TSPO) using positron emission tomography (PET) indicated high levels of TSPO in the brains of active or former National Football League (NFL) players.…
View article: Pilot imaging of the colony stimulating factor 1 receptor in the brains of virally-suppressed individuals with HIV
Pilot imaging of the colony stimulating factor 1 receptor in the brains of virally-suppressed individuals with HIV Open
Objective: Neuroimmune activation is a putative driver of cognitive impairment in people with HIV (PWH), even in the age of modern antiretroviral therapy. Nevertheless, imaging of the microglial marker, the 18 kDa translocator protein (TSP…
View article: First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor
First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor Open
Purpose Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions outside the living brain.…
View article: First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony stimulating factor 1 receptor
First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony stimulating factor 1 receptor Open
Purpose: Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions outside the intact livin…
View article: System-level optimization in spectroscopic photoacoustic imaging of prostate cancer
System-level optimization in spectroscopic photoacoustic imaging of prostate cancer Open
View article: PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC
PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC Open
Purpose: We report findings from the first-in-human study of [ 11 C]MDTC, a radiotracer developed to image the cannabinoid receptor type 2 (CB2R) with positron emission tomography (PET). Methods: Ten healthy adults were imaged according to…
View article: An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications
An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications Open
The chemokine receptor 4 (CXCR4) is a promising diagnostic and therapeutic target for the management of various cancers. CXCR4 has been utilized in immunotherapy, targeted drug delivery, and endoradiotherapy. Poly(amidoamine) [PAMAM] dendr…
View article: Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance
Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance Open
View article: Dual-Modality PET–SPECT Image-Guided Pretargeting Delivery in HER2(+) Breast Cancer Models
Dual-Modality PET–SPECT Image-Guided Pretargeting Delivery in HER2(+) Breast Cancer Models Open
Pretargeted drug delivery has been explored for decades as a promising approach in cancer therapy. An image-guided pretargeting strategy significantly enhances the intrinsic advantages of this approach since imaging the pretargeting step c…
View article: First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET
First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET Open
View article: Measurement of PET Quantitative Bias In Vivo
Measurement of PET Quantitative Bias In Vivo Open
Quantitative imaging biomarkers are widely used in PET for both research and clinical applications, yet bias in the underlying image data has not been well characterized. In the absence of a readily available reference standard for in vivo…
View article: PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP
PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP Open
View article: <sup>11</sup>C-PABA as a PET Radiotracer for Functional Renal Imaging: Preclinical and First-in-Human Study
<sup>11</sup>C-PABA as a PET Radiotracer for Functional Renal Imaging: Preclinical and First-in-Human Study Open
para-Aminobenzoic acid (PABA) has been previously used as an exogenous marker to verify completion of 24-h urine sampling. Therefore, we hypothesized that PABA radiolabeled with 11C might allow high-quality dynamic PET of…
View article: A side-by-side evaluation of [18F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography
A side-by-side evaluation of [18F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography Open
Neuroendocrine tumors (NETs) are an extremely heterogenous group of malignancies with variable clinical behavior. Molecular imaging of patients with NETs allows for effective patient stratification and treatment guidance and is crucial in …
View article: High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using <sup>18</sup>F-ASEM PET
High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using <sup>18</sup>F-ASEM PET Open
Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in the pathophysiology of Alzheimer’s disease. (18)F-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-(18)F-fluorodibenzo[b,d]thiophene 5,5-…
View article: PET imaging of distinct brain uptake of a nanobody and similarly-sized PAMAM dendrimers after intra-arterial administration
PET imaging of distinct brain uptake of a nanobody and similarly-sized PAMAM dendrimers after intra-arterial administration Open
View article: PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)
PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R) Open
Significance [ 11 C]CPPC [5-cyano- N -(4-(4-[ 11 C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide] is a PET radiotracer specific for CSF1R, a microglia-specific marker. This compound can be used as a noninvasive tool fo…
View article: Development of [<sup>18</sup>F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide
Development of [<sup>18</sup>F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide Open
Expression of programmed cell death ligand 1 (PD-L1) within tumors is an important biomarker for guiding immune checkpoint therapies; however, immunohistochemistry-based methods of detection fail to provide a comprehensive picture of PD-L1…
View article: Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET
Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET Open