Wolf Eilenberg
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View article: Prefabricated pericardial bovine grafts for reconstruction of lower extremity under infectious conditions
Prefabricated pericardial bovine grafts for reconstruction of lower extremity under infectious conditions Open
Background: Biological graft options for vascular reconstruction following graft infection (VGI) of lower extremity remain scarce. Custom-made nature of previously reported bovine pericardial grafts (BPG) comes at an expense of serious mat…
View article: Distinct Roles of Monocyte Subsets in Cancer
Distinct Roles of Monocyte Subsets in Cancer Open
While the distinct roles of lymphocyte populations are well characterized in adaptive immunity, the phenotypic and functional diversity of innate immune cells is less explored. In recent years, subsets of monocytes have gained attention, a…
View article: MetAAA Trial Patients Receiving Metformin Therapy Show Limited Improvement in Quality of Life Compared to AAA Patients with Placebo Intake—A Double-Blind, Randomized, and Placebo-Controlled Trial
MetAAA Trial Patients Receiving Metformin Therapy Show Limited Improvement in Quality of Life Compared to AAA Patients with Placebo Intake—A Double-Blind, Randomized, and Placebo-Controlled Trial Open
Background: Abdominal aortic aneurysm (AAA) is a multifactorial vascular disease with limited therapeutic options, as no pharmacological treatments currently exist to mitigate the progression of small AAAs. Quality of life (QoL) has emerge…
View article: Histopathological evaluation of abdominal aortic aneurysms with deep learning
Histopathological evaluation of abdominal aortic aneurysms with deep learning Open
Computational analysis of histopathological specimens holds promise in identifying biomarkers, elucidating disease mechanisms, and streamlining clinical diagnosis. However, the application of deep learning techniques in vascular pathology …
View article: Vitamin D Deficiency as an Independent Predictor for Plaque Vulnerability and All-Cause Mortality in Patients with High-Grade Carotid Disease
Vitamin D Deficiency as an Independent Predictor for Plaque Vulnerability and All-Cause Mortality in Patients with High-Grade Carotid Disease Open
Objectives: The mechanisms linking vitamin D deficiency to carotid artery stenosis (CAS) remain unclear. Data on cardiovascular outcomes in CAS patients with vitamin D deficiency are limited. We investigated the association of vitamin D de…
View article: Intraspinal vascular perfusion territories of the descending thoracic aorta
Intraspinal vascular perfusion territories of the descending thoracic aorta Open
OBJECTIVES Our study aims at characterizing the intraspinal vascular perfusion territories (angiosomes) of the descending thoracic aorta in a cadaver stetting to understand the principles of blood supply to the spinal cord and to provide t…
View article: Editor's Choice – Metformin to Inhibit Progression of Abdominal Aortic Aneurysm: A Randomised, Placebo Controlled Clinical Trial
Editor's Choice – Metformin to Inhibit Progression of Abdominal Aortic Aneurysm: A Randomised, Placebo Controlled Clinical Trial Open
No difference in AAA growth between the metformin and placebo groups was observed. Patients had excellent adherence and tolerability to metformin therapy. Considering the lack of power of the study, larger randomised controlled trials with…
View article: Anatomy of the aortic segmental arteries—the fundamentals of preventing spinal cord ischemia in aortic aneurysm repair
Anatomy of the aortic segmental arteries—the fundamentals of preventing spinal cord ischemia in aortic aneurysm repair Open
Objective Spinal cord ischemia due to damage or occlusion of the orifices of aortic segmental arteries (ASA) is a serious complication of open and endovascular aortic repair. Our study aims to provide detailed descriptions of the proximal …
View article: Circulating monocyte populations as biomarker for abdominal aortic aneurysms: a single-center retrospective cohort study
Circulating monocyte populations as biomarker for abdominal aortic aneurysms: a single-center retrospective cohort study Open
Background Abdominal aortic aneurysm (AAA) development is driven by inflammation, in particular myeloid cells, which represent attractive biomarker candidates. Yet to date, the maximum aortic diameter is the only clinically applied predict…
View article: Histopathological evaluation of abdominal aortic aneurysms with deep learning
Histopathological evaluation of abdominal aortic aneurysms with deep learning Open
Computational analysis of histopathological specimens holds promise in identifying biomarkers, elucidating disease mechanisms, and streamlining clinical diagnosis. However, the application of deep learning techniques in vascular pathology …
View article: Abdominal aortic aneurysms’ histomorphology differs on the individual patient level and is not associated with classic risk factors – the HistAAA study
Abdominal aortic aneurysms’ histomorphology differs on the individual patient level and is not associated with classic risk factors – the HistAAA study Open
Objective Abdominal aortic aneurysm (AAA) treatment is upon a diameter threshold by open (OAR) or endovascular aortic repair. So far, attempts for medical growth abrogation have failed. This study aims to elucidate the heterogeneity of AAA…
View article: Preliminary results of the Austrian National Registry regarding the novel iCover bridging stent graft in fenestrated endovascular aortic repair
Preliminary results of the Austrian National Registry regarding the novel iCover bridging stent graft in fenestrated endovascular aortic repair Open
The iCover represents a feasible BSG for fEVAR with an excellent safety profile and technical success rate in the early phase. Prudent post-dilatation and monitoring of the proximal and distal stent ends can potentially further improve out…
View article: Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting
Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting Open
Neutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, includin…
View article: Diagnostic Utility of a Combined MPO/D-Dimer Score to Distinguish Abdominal Aortic Aneurysm from Peripheral Artery Disease
Diagnostic Utility of a Combined MPO/D-Dimer Score to Distinguish Abdominal Aortic Aneurysm from Peripheral Artery Disease Open
Abdominal aortic aneurysm (AAA) and peripheral artery disease (PAD) share pathophysiological mechanisms including the activation of the fibrinolytic and innate immune system, which explains the analysis of D-dimer and myeloperoxidase (MPO)…
View article: Operation time and clinical outcomes for open infrarenal abdominal aortic aneurysms to remain stable in the endovascular era
Operation time and clinical outcomes for open infrarenal abdominal aortic aneurysms to remain stable in the endovascular era Open
Objective Endovascular aortic repair (EVAR) has become a routine procedure worldwide. Ultimately, the increasing number of EVAR cases entails changing conditions for open surgical repair (OSR) regarding patient selection, complexity, and s…
View article: Evaluation of national institute for health and care excellence guidance for ruptured abdominal aortic aneurysms by emulating a hypothetical target trial
Evaluation of national institute for health and care excellence guidance for ruptured abdominal aortic aneurysms by emulating a hypothetical target trial Open
Objective This retrospective study evaluates the performance of UK National Institute for Health and Care Excellence (NICE) Guidelines on management of ruptured abdominal aortic aneurysms in a “real world setting” by emulating a hypothetic…
View article: Comparing maximum diameter and volume when assessing the growth of small abdominal aortic aneurysms using longitudinal CTA data: cohort study
Comparing maximum diameter and volume when assessing the growth of small abdominal aortic aneurysms using longitudinal CTA data: cohort study Open
Background: Monitoring of abdominal aortic aneurysms (AAAs) is currently based on serial measurements of maximum aortic diameter. Additional assessment of aneurysm volume has previously been proposed to possibly improve growth prediction a…
View article: Quantitation of oxidized nuclear and mitochondrial DNA in plasma samples of patients with abdominal aortic aneurysm
Quantitation of oxidized nuclear and mitochondrial DNA in plasma samples of patients with abdominal aortic aneurysm Open
There is accumulating evidence that pro-inflammatory features are inherent to mitochondrial DNA and oxidized DNA species. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) is the most frequently studied oxidatively generated lesion. Modified…
View article: Early experience with bridging stent graft deployment without sheath support in branched and fenestrated endovascular aortic repair
Early experience with bridging stent graft deployment without sheath support in branched and fenestrated endovascular aortic repair Open
This study reports the outcomes of three currently available TV stenting approaches. Previously reported SMART technique, and its modified version (NSG) proved to be a safe alternative to historically established TV stenting technique with…
View article: Biomarkers of Spinal Cord Injury in Patients Undergoing Complex Endovascular Aortic Repair Procedures—A Narrative Review of Current Literature
Biomarkers of Spinal Cord Injury in Patients Undergoing Complex Endovascular Aortic Repair Procedures—A Narrative Review of Current Literature Open
Complex endovascular aortic repair (coEVAR) of thoracoabdominal aortic aneurysms (TAAA) has greatly evolved in the past decades. Despite substantial improvements of postoperative care, spinal cord injury (SCI) remains the most devastating …
View article: MetAAA trial patients show superior quality of life compared to patients under regular surveillance for small AAA: a single-center retrospective cohort study
MetAAA trial patients show superior quality of life compared to patients under regular surveillance for small AAA: a single-center retrospective cohort study Open
Background: Abdominal aortic aneurysm (AAA) is a multifactorial vascular disease associated with high morbidity and mortality. Currently, surgical intervention is the only treatment option, and there is no drug therapy available for AAA. H…
View article: Monoplane versus biplane fluoroscopy in patients undergoing fenestrated/branched endovascular aortic repair
Monoplane versus biplane fluoroscopy in patients undergoing fenestrated/branched endovascular aortic repair Open
F/B-EVAR procedures performed under BPA guidance were associated with a significant decrease in operation time.
View article: Towards Precritical Medical Therapy of the Abdominal Aortic Aneurysm
Towards Precritical Medical Therapy of the Abdominal Aortic Aneurysm Open
Pharmacotherapy for abdominal aortic aneurysm (AAA) can be useful for prevention, especially in people at higher risk, for slowing down AAA progression, as well as for post-surgery adjuvant treatment. Our review focuses on novel pharmacoth…