Wolfgang Drexler
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View article: Impact of image preprocessing on dermatological OCTA vessel segmentation: a DERMA-OCTA study
Impact of image preprocessing on dermatological OCTA vessel segmentation: a DERMA-OCTA study Open
Combining 2D and 3D models and using topology-aware indices provide a full, clinically relevant evaluation of algorithm performance.
View article: Optical Coherence Tomography Angiography (OCTA) Captures Early Micro-Vascular Remodeling in Non-Melanoma Skin Cancer During Superficial Radiotherapy: A Proof-of-Concept Study
Optical Coherence Tomography Angiography (OCTA) Captures Early Micro-Vascular Remodeling in Non-Melanoma Skin Cancer During Superficial Radiotherapy: A Proof-of-Concept Study Open
Background/Objectives: This proof-of-concept study evaluated whether optical coherence tomography angiography (OCTA) can non-invasively capture micro-vascular alterations in non-melanoma skin cancer (NMSC) lesions during and after superfic…
View article: Demystifying the feasibility of in vivo nonresonant Raman spectroscopy of the human retina
Demystifying the feasibility of in vivo nonresonant Raman spectroscopy of the human retina Open
Early detection of retinal molecular biomarkers is crucial for addressing the unmet clinical need to prevent irreversible neural tissue damage in ophthalmic and neurodegenerative diseases. Among emerging molecular sensing techniques, non-r…
View article: DERMA-OCTA: A Comprehensive Dataset and Preprocessing Pipeline for Dermatological OCTA Vessel Segmentation
DERMA-OCTA: A Comprehensive Dataset and Preprocessing Pipeline for Dermatological OCTA Vessel Segmentation Open
Optical coherence tomography angiography (OCTA) has emerged as a promising tool for non-invasive vascular imaging in dermatology. However, the field lacks standardized methods for processing and analyzing these complex images, as well as s…
View article: Tethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett’s oesophageal neoplasia
Tethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett’s oesophageal neoplasia Open
Endoscopic detection of oesophageal cancer (EC) often occurs late in disease development, leading to high mortality rates. Improved technologies are urgently needed for earlier EC detection. Here we research an endoscopic ultra-broadband a…
View article: Spectral Region Optimization and Machine Learning-Based Nonlinear Spectral Analysis for Raman Detection of Cardiac Fibrosis Following Myocardial Infarction
Spectral Region Optimization and Machine Learning-Based Nonlinear Spectral Analysis for Raman Detection of Cardiac Fibrosis Following Myocardial Infarction Open
Cardiac fibrosis following myocardial infarction plays a critical role in the formation of scar tissue and contributes to ventricular arrhythmias, including ventricular tachycardia and sudden cardiac death. Current clinical diagnostics use…
View article: Comparison of conventional and radiomics-based analysis of myocardial infarction using multimodal non-linear optical microscopy
Comparison of conventional and radiomics-based analysis of myocardial infarction using multimodal non-linear optical microscopy Open
Myocardial infarction, a leading cause of mortality worldwide, leaves survivors at significant risk of recurrence caused by scar-related re-entrant ventricular tachyarrhythmias. Effective treatment with ablation therapy requires a precise …
View article: Multimodal Optical Imaging Combined with Radiomic Analysis for Fibrotic Cardiac Tissue Investigation
Multimodal Optical Imaging Combined with Radiomic Analysis for Fibrotic Cardiac Tissue Investigation Open
Understanding the process of fibrotic scarring of the myocardium is critical for the diagnosis and risk stratification of life-threatening cardiac dysfunction. Complex changes in structure, composition, and conductivity occurring at differ…
View article: Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model
Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model Open
Aberrant angiogenesis is a hallmark of many pathologies. In cancer, tumor growth and metastasis strongly depend on angiogenesis triggered by neoplastic cells. Antiangiogenic therapies are approved to treat different kinds of cancer. Howeve…
View article: Image Quality in Adaptive Optics Optical Coherence Tomography of Diabetic Patients
Image Quality in Adaptive Optics Optical Coherence Tomography of Diabetic Patients Open
Background/Objectives: An assessment of the retinal image quality in adaptive optics optical coherence tomography (AO-OCT) is challenging. Many factors influence AO-OCT imaging performance, leading to greatly varying imaging results, even …
View article: Context-Aware Real-Time Semantic View Expansion of Intraoperative 4D OCT
Context-Aware Real-Time Semantic View Expansion of Intraoperative 4D OCT Open
Four-dimensional microscope-integrated optical coherence tomography enables volumetric imaging of tissue structures and tool-tissue interactions in ophthalmic surgery at interactive update rates. This enables surgeons to undertake particul…
View article: Cardiac Microanatomy Imaging Using Forward-viewing Optical Coherence Tomography Endoscope
Cardiac Microanatomy Imaging Using Forward-viewing Optical Coherence Tomography Endoscope Open
By enhancing visualization at the cellular level, this method may contribute to a better understanding of cardiac physiology and pathology, potentially extending future diagnostic and therapeutic strategies.
View article: Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina
Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina Open
In vivo access to molecular information of retinal tissue is considered to play a critical role in enabling early diagnosis of ophthalmic and neurodegenerative diseases. The current gold standard of retina imaging, optical coherence tomogr…
View article: CMOS optoelectronic spectrometer based on photonic integrated circuit for in vivo 3D optical coherence tomography
CMOS optoelectronic spectrometer based on photonic integrated circuit for in vivo 3D optical coherence tomography Open
Photonic integrated circuits (PICs) represent a promising technology for the much-needed medical devices of today. Their primary advantage lies in their ability to integrate multiple functions onto a single chip, thereby reducing the compl…
View article: Introduction and Validation of Low-Cost Ocular Biometry in Healthy and Cataractous Eyes Using a Thermally Tunable Swept-Source Laser
Introduction and Validation of Low-Cost Ocular Biometry in Healthy and Cataractous Eyes Using a Thermally Tunable Swept-Source Laser Open
Optical biometry using a thermally tunable VCSEL swept-source light source has the potential to provide clinically relevant biometric parameters at an unprecedented 100-fold lower price point than currently used state-of-the-art optical bi…
View article: Association of microaneurysms with retinal vascular alterations in patients with retinal vein occlusion
Association of microaneurysms with retinal vascular alterations in patients with retinal vein occlusion Open
MAs were associated with extensive NPA, the presence of CV, GV, and TV. There was no correlation between the diameter of the MA and the adjacent intraretinal fluid in our predominantly pretreated RVO study patients.
View article: Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor
Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor Open
We present improvements on the adaptive optics (AO) correction method using a pyramid wavefront sensor (P-WFS) and introduce a novel approach for closed-loop focus shifting in retinal imaging. The method’s efficacy is validated through in …
View article: Segmentation and Multi-Timepoint Tracking of 3D Cancer Organoids from Optical Coherence Tomography Images Using Deep Neural Networks
Segmentation and Multi-Timepoint Tracking of 3D Cancer Organoids from Optical Coherence Tomography Images Using Deep Neural Networks Open
Recent years have ushered in a transformative era in in vitro modeling with the advent of organoids, three-dimensional structures derived from stem cells or patient tumor cells. Still, fully harnessing the potential of organoids requires a…
View article: Exploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography
Exploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography Open
Low-cost optical coherence tomography has recently emerged as a growing field due to the increased need for general availability of OCT devices outside of the clinics. One of the main obstacles in creating low-cost SS-OCT systems is the pr…
View article: Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes
Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes Open
We demonstrate the visualization capabilities of a cutting edge swept-source OCT system integrated into an ophthalmic surgical microscope during cataract surgery.
View article: Ultrasound-induced reorientation for multi-angle optical coherence tomography
Ultrasound-induced reorientation for multi-angle optical coherence tomography Open
Organoid and spheroid technology provide valuable insights into developmental biology and oncology. Optical coherence tomography (OCT) is a label-free technique that has emerged as an excellent tool for monitoring the structure and functio…
View article: CMOS Optoelectronic Spectrometer based on Photonic Integrated Circuits for In Vivo 3D Optical Coherence Tomography
CMOS Optoelectronic Spectrometer based on Photonic Integrated Circuits for In Vivo 3D Optical Coherence Tomography Open
Photonics integrated circuits (PICs) represent a promising technology for the much-needed medical devices of today. Their primary advantage lies in their ability to integrate multiple functions onto a single chip, thereby reducing the comp…
View article: Microaneurysm detection using high‐speed megahertz optical coherence tomography angiography in advanced diabetic retinopathy
Microaneurysm detection using high‐speed megahertz optical coherence tomography angiography in advanced diabetic retinopathy Open
Purpose To compare detection rates of microaneurysms (MAs) on high‐speed megahertz optical coherence tomography angiography (MHz‐OCTA), fluorescein angiography (FA) and colour fundus photography (CF) in patients with diabetic retinopathy (…
View article: Quantitative parameter reconstruction from optical coherence tomographic data
Quantitative parameter reconstruction from optical coherence tomographic data Open
Quantitative tissue information, like the light scattering properties, is considered as a key player in the detection of cancerous cells in medical diagnosis. A promising method to obtain these data is optical coherence tomography (OCT). I…
View article: Ultrasound-Induced Reorientation for Multi-Angle Optical Coherence Tomography
Ultrasound-Induced Reorientation for Multi-Angle Optical Coherence Tomography Open
Organoid and spheroid technology have recently provided great insights into oncology, developmental biology as well as personalized medicine. Among the methods to optically monitor the structural and functional organization of such samples…
View article: Visible light photoacoustic ophthalmoscopy and near-infrared-II optical coherence tomography in the mouse eye
Visible light photoacoustic ophthalmoscopy and near-infrared-II optical coherence tomography in the mouse eye Open
Non-invasive imaging plays a crucial role in diagnosing and studying eye diseases. However, existing photoacoustic ophthalmoscopy (PAOM) techniques in mice have limitations due to handling restrictions, suboptimal optical properties, limit…
View article: DEBI-NN: Distance-encoding biomorphic-informational neural networks for minimizing the number of trainable parameters
DEBI-NN: Distance-encoding biomorphic-informational neural networks for minimizing the number of trainable parameters Open
Modern artificial intelligence (AI) approaches mainly rely on neural network (NN) or deep NN methodologies. However, these approaches require large amounts of data to train, given, that the number of their trainable parameters has a polyno…