Wölfram Karges
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View article: Increased cardiovascular risk in people with <scp>LADA</scp> in comparison to type 1 diabetes and type 2 diabetes: Findings from the <scp>DPV</scp> registry in Germany and Austria
Increased cardiovascular risk in people with <span>LADA</span> in comparison to type 1 diabetes and type 2 diabetes: Findings from the <span>DPV</span> registry in Germany and Austria Open
Introduction We aimed to characterise and compare individuals diagnosed with type 1 diabetes (T1D), latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D), in a real‐world setting. Methods Anthropometric and clinical data fr…
View article: Factors associated with diabetic foot ulcers and lower limb amputations in type 1 and type 2 diabetes supported by real‐world data from the German/Austrian DPV registry
Factors associated with diabetic foot ulcers and lower limb amputations in type 1 and type 2 diabetes supported by real‐world data from the German/Austrian DPV registry Open
Aims Diabetic foot ulcer (DFU) is a leading cause of lower limb amputations in people with diabetes. This study was aimed to retrospectively analyze factors affecting DFU using real‐world data from a large, prospective central‐European dia…
View article: Clinical characteristics and cardiovascular risk profile in children and adolescents with latent autoimmune diabetes: Results from the German/Austrian prospective diabetes follow‐up registry
Clinical characteristics and cardiovascular risk profile in children and adolescents with latent autoimmune diabetes: Results from the German/Austrian prospective diabetes follow‐up registry Open
In terms of CV risk, classifying children and adolescents with diabetes as LADYs provides no additional benefit. Instead, clinical diagnosis seems to better assign individuals to appropriate risk groups for increased CV risk profiles.
View article: Comorbidities in Recent-Onset Adult Type 1 Diabetes: A Comparison of German Cohorts
Comorbidities in Recent-Onset Adult Type 1 Diabetes: A Comparison of German Cohorts Open
Aims Restrictive exclusion criteria from different study populations may limit the generalizability of the observations. By comparing two differently designed German cohorts, we assessed the prevalence of cardiovascular risk factors and di…
View article: Immune‐checkpoint inhibitor‐associated diabetes compared to other diabetes types ‐ A prospective, matched control study
Immune‐checkpoint inhibitor‐associated diabetes compared to other diabetes types ‐ A prospective, matched control study Open
Background To describe checkpoint inhibitor‐induced diabetes mellitus (CPI‐DM) and to compare with regular type 1 (T1DM), type 2 (T2DM), and medication‐induced diabetes mellitus (MI‐DM). Methods We included 88 177 adult patients from the D…
View article: Characteristics of Patients with Type 1 Diabetes and Additional Autoimmune Disease in the DPV Registry
Characteristics of Patients with Type 1 Diabetes and Additional Autoimmune Disease in the DPV Registry Open
Context Autoimmune diseases affect ~8% of the population. Type 1 diabetes mellitus (T1DM) is linked to other autoimmune diseases (AIDs), such as autoimmune thyroid disease or Addison’s disease (AD), that may impact diabetes therapy and out…
View article: Adults’ Adherence to Growth Hormone Replacement in Relation to Medication-Related Beliefs, Coping and Quality of Life - An Exploratory Analysis
Adults’ Adherence to Growth Hormone Replacement in Relation to Medication-Related Beliefs, Coping and Quality of Life - An Exploratory Analysis Open
Introduction Little is known about psychological reasons associated with adherence to growth hormone (GH) replacement therapy (GHRx) in adults. As in other chronic diseases, medication-related beliefs, coping strategies and disease impact …
View article: Motivation for and adherence to growth hormone replacement therapy in adults with hypopituitarism: the patients‘ perspective
Motivation for and adherence to growth hormone replacement therapy in adults with hypopituitarism: the patients‘ perspective Open
Introduction While reasons for non-adherence in children requiring growth hormone (GH) replacement (GH-Rx) are well researched, few studies have investigated adherence in adult GH deficient patients. Against the background of the adverse m…
View article: Q fever: Evidence of a massive yet undetected cross‐border outbreak, with ongoing risk of extra mortality, in a Dutch–German border region
Q fever: Evidence of a massive yet undetected cross‐border outbreak, with ongoing risk of extra mortality, in a Dutch–German border region Open
Our findings were suggestive of widespread cross-border transmission, with thousands of undetected infections, arguing for intensified cross-border collaboration and surveillance and screening of individuals susceptible to chronic Q fever …
View article: Once-weekly Somapacitan is Effective and Well Tolerated in Adults with GH Deficiency: A Randomized Phase 3 Trial
Once-weekly Somapacitan is Effective and Well Tolerated in Adults with GH Deficiency: A Randomized Phase 3 Trial Open
Context Growth hormone (GH) replacement requires daily GH injections, which is burdensome for some adult patients with GH deficiency (AGHD). Objective To demonstrate efficacy and safety of somapacitan, a once-weekly reversible albumin-bind…
View article: The Transatlantic HbA<sub>1c</sub> gap: differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry
The Transatlantic HbA<sub>1c</sub> gap: differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry Open
Aim To compare HbA 1c levels across the lifespan in people with type 1 diabetes in the USA with those in Germany/Austria, and to examine potential differences in HbA 1c levels between sexes, insulin delivery methods and minority status. Me…
View article: Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial
Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial Open
Objective Somapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily Norditropin ® . Local tolerabi…
View article: Achievement of treatment goals for secondary prevention of myocardial infarction or stroke in 29,325 patients with type 2 diabetes: a German/Austrian DPV-multicenter analysis
Achievement of treatment goals for secondary prevention of myocardial infarction or stroke in 29,325 patients with type 2 diabetes: a German/Austrian DPV-multicenter analysis Open
Achievement of treatment goals in secondary prevention of MI, or stroke in subjects with type 2 diabetes needs improvement. Target goals were met more frequently in patients with MI compared to subjects with stroke. Especially the use of I…