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View article: Protease-activated receptor 4 deficiency increases mortality, intracranial bleeding, and blood-brain barrier impairment following traumatic brain injury in mice
Protease-activated receptor 4 deficiency increases mortality, intracranial bleeding, and blood-brain barrier impairment following traumatic brain injury in mice Open
View article: Simvastatin competitively inhibits cellular signaling of lipid-binding antiphospholipid antibodies
Simvastatin competitively inhibits cellular signaling of lipid-binding antiphospholipid antibodies Open
Our data show that statins prevent monocyte activation and TF-triggered coagulation by interfering with binding of lipid-binding aPLs to the EPCR/LBPA complex on the cell surface of monocytes. These findings may help to understand the obse…
View article: Coagulation proteases modulate nucleic acid uptake and cGAS-STING-IFN induction in the tumor microenvironment
Coagulation proteases modulate nucleic acid uptake and cGAS-STING-IFN induction in the tumor microenvironment Open
Malignancies increase the risk for thrombosis and metastasis dependent on complex interactions of innate immune cells, platelets, and the coagulation system. Immunosuppressive functions of platelets and macrophage-derived coagulation facto…
View article: A commitment to global collaboration, welcoming international participation and advancing science for the benefit of patients
A commitment to global collaboration, welcoming international participation and advancing science for the benefit of patients Open
On behalf of the International Society on Thrombosis and Haemostasis (ISTH) Council and Annual Congress Planning Committee (ACPC) As we prepare for the International Society on Thrombosis and Haemostasis (ISTH) 2025 Congress in Washington,…
View article: Human and mouse platelet transcriptomes and proteomes for phenotyping 3474 genes with hemostatic and platelet traits
Human and mouse platelet transcriptomes and proteomes for phenotyping 3474 genes with hemostatic and platelet traits Open
The hemostatic process relies on platelet and coagulation activation, with additional roles of red blood cells and the vessel wall. By systematic screening of databases for gene-linked information on hemostasis, we collected phenotypic pro…
View article: Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling
Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling Open
Coagulation factors are responsible for blood clot formation yet have also non-canonical functions as signalling molecules. In this context, they can activate protease-activated receptors (PARs) ubiquitously expressed in the vasculature. D…
View article: Gut Protease Signaling Controls Postprandial Incretin Balance and Glucose Homeostasis in Diet-Induced Obesity
Gut Protease Signaling Controls Postprandial Incretin Balance and Glucose Homeostasis in Diet-Induced Obesity Open
View article: Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting
Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting Open
View article: Assessment of psychological resilience in a large cohort of the general population: Validation and norm values of the RS-5
Assessment of psychological resilience in a large cohort of the general population: Validation and norm values of the RS-5 Open
Background Psychological resilience is known as a protective factor against mental health disorders for which valid measures are indispensable. The present work aims to evaluate the Resilience Scale-5 (RS-5) psychometrically, and provide n…
View article: Exposure to aircraft noise exacerbates cardiovascular and oxidative damage in three mouse models of diabetes
Exposure to aircraft noise exacerbates cardiovascular and oxidative damage in three mouse models of diabetes Open
Aims Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)–mediated cardiovascular damage…
View article: Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer Open
View article: Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2
Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2 Open
Imbalances in proteolytic activity have been linked to the development of inflammatory bowel diseases (IBD) and experimental colitis. Proteases in the intestine play important roles in maintaining homeostasis, but exposure of mucosal tissu…
View article: Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression
Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression Open
Inflammation promotes solid tumor progression, but how regulatory mechanisms of inflammation may affect leukemia is less well studied. Using annexin A5 (ANXA5), a calcium-binding protein known for apoptosis, which we discovered to be diffe…
View article: Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation Open
BACKGROUND: Endothelial activation promotes the release of procoagulant extracellular vesicles and inflammatory mediators from specialized storage granules. Endothelial membrane exocytosis is controlled by phosphorylation. We hypothesized …
View article: TF-FVIIa PAR2-β-Arrestin Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection of Mice
TF-FVIIa PAR2-β-Arrestin Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection of Mice Open
BACKGROUND: Accumulating evidence implicates the activation of G-protein–coupled PARs (protease-activated receptors) by coagulation proteases in the regulation of innate immune responses. METHODS: Using mouse models with genetic alteration…
View article: Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome
Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome Open
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of pathogenic antiphospholipid antibodies (aPL). Since approximately 30 years ago, lipid-binding aPL, which do not require a protein cofactor, have …
View article: Immune damage in Long Covid
Immune damage in Long Covid Open
Links between the complement and coagulation systems could lead to Long Covid therapies
View article: Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling
Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling Open
Protease activated receptors (PARs) are cleaved by coagulation proteases and thereby connect hemostasis with innate immune responses. Signaling of the tissue factor (TF) complex with factor VIIa (FVIIa) via PAR2 stimulates extracellular si…
View article: PB0724 TF-FVIIa-PAR2-β-Arrestin Signaling Regulates Monocyte/ Macrophage Responses to Double Stranded RNA
PB0724 TF-FVIIa-PAR2-β-Arrestin Signaling Regulates Monocyte/ Macrophage Responses to Double Stranded RNA Open
View article: OC 49.4 Targeting Myeloid Cell Coagulation Signaling Blocks Map Kinase/TGF-β1 Driven Fibrotic Remodeling, Improves Cardiac Function and Improves Survival in Ischemic Heart Failure
OC 49.4 Targeting Myeloid Cell Coagulation Signaling Blocks Map Kinase/TGF-β1 Driven Fibrotic Remodeling, Improves Cardiac Function and Improves Survival in Ischemic Heart Failure Open
View article: PB1436 PAR1 Knockout Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells Display Higher Tissue Factor-Dependent Thrombin Generation Compared to Wild Type
PB1436 PAR1 Knockout Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells Display Higher Tissue Factor-Dependent Thrombin Generation Compared to Wild Type Open
Background: Von Willebrand factor (VWF) plays an important role in the initiation of platelet adhesion.Defective VWF causes bleeding and high VWF plasma levels are associated with thrombosis.We have shown inhibition of endothelial murine V…
View article: Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27
Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27 Open
Externalized histones erupt from the nucleus as extracellular traps, are associated with several acute and chronic lung disorders, but their implications in the molecular pathogenesis of interstitial lung disease are incompletely defined. …
View article: Author Correction: Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling
Author Correction: Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling Open
View article: Circulating microRNAs predict recurrence and death following venous thromboembolism
Circulating microRNAs predict recurrence and death following venous thromboembolism Open
Circulating miRNAs predicted the risk of recurrence or death after VTE over several years, both in the acute and chronic phases.
View article: Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling
Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling Open
View article: Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial
Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial Open
BACKGROUND: Thrombo-inflammation is central to COVID-19-associated coagulopathy. TF (tissue factor), a driver of disordered coagulation and inflammation in viral infections, may be a therapeutic target in COVID-19. The safety and efficacy …
View article: Crohn’s disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice
Crohn’s disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice Open
Emerging evidence implicates microbial proteolytic activity in ulcerative colitis (UC), but whether it also plays a role in Crohn's disease (CD) remains unclear. We investigated the effects of colonizing adult and neonatal germ-free C57BL/…
View article: Supplementary Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases
Supplementary Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases Open
Supplementary Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases
View article: Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases
Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases Open
Tissue factor/coagulation factor VII (fVII) complex formation on the surface of cancer cells plays important roles in cancer biology, such as cell migration and invasion, angiogenesis, and antiapoptotic effects. We recently found that vari…
View article: Supplementary Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases
Supplementary Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases Open
Supplementary Data from Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases