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View article: Oral functional limitation and risk of frailty onset in older adults: a sex-stratified 4-Year cohort study with competing risk analysis
Oral functional limitation and risk of frailty onset in older adults: a sex-stratified 4-Year cohort study with competing risk analysis Open
Background Oral functional decline may contribute to frailty in older adults by affecting nutrition, physical performance, and psychosocial well-being. However, longitudinal evidence using rigorous analytic approaches, including competing …
View article: Integrated Care of Older Patients with Frailty in Primary Care (ICOOP-Frail): a pilot randomized controlled trial and cost-effectiveness analysis
Integrated Care of Older Patients with Frailty in Primary Care (ICOOP-Frail): a pilot randomized controlled trial and cost-effectiveness analysis Open
CRIS (KCT0005922), registered on February 22, 2021.
View article: Validation of Sarcopenic Obesity Screening Tools: A Cross-Sectional Analysis Based on ESPEN and EASO Criteria
Validation of Sarcopenic Obesity Screening Tools: A Cross-Sectional Analysis Based on ESPEN and EASO Criteria Open
Background and Objectives: Sarcopenic obesity, characterized by sarcopenia and obesity, is associated with adverse outcomes. The recent consensus from the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Asso…
View article: Obesity indicators and risk of mortality and functional health outcomes in Asian community-dwelling older adults: A systematic review and meta-analysis
Obesity indicators and risk of mortality and functional health outcomes in Asian community-dwelling older adults: A systematic review and meta-analysis Open
Obesity in older adults is associated with adverse health outcomes, and its coexistence with sarcopenia may accelerate these risks. While diagnostic criteria for sarcopenic obesity were recently proposed in Europe, the applicability of obe…
View article: Advancing fall risk prediction in older adults with cognitive frailty: A machine learning approach using 2-year clinical data
Advancing fall risk prediction in older adults with cognitive frailty: A machine learning approach using 2-year clinical data Open
Falls are a critical concern in older adults with cognitive frailty (CF). However, previous studies have not fully examined whether machine learning models can predict falls in older individuals with CF. The 2-year longitudinal data set fr…
View article: Models for age-specific estimation of appendicular skeletal muscle mass using the ultrasound-measured rectus femoris muscle thickness
Models for age-specific estimation of appendicular skeletal muscle mass using the ultrasound-measured rectus femoris muscle thickness Open
Ultrasound is a useful tool for assessing muscle status. Estimation equations based on ultrasound measurements have been used to approximate appendicular skeletal muscle mass (ASM). However, age-related changes in skeletal muscle may influ…
View article: Circulating miR‐144‐3p as a Novel Independent Biomarker Associated With Low Muscle Strength Among Older Adults
Circulating miR‐144‐3p as a Novel Independent Biomarker Associated With Low Muscle Strength Among Older Adults Open
Background Low muscle strength, a key component of sarcopenia, is significant in the development of adverse health outcomes among older adults. MicroRNAs (miRNAs) have been implicated in mechanisms of sarcopenia; however, their specific fu…
View article: Association between perceived neighborhood environment, sedentary behavior, walking, and moderate-to-vigorous physical activity and frailty: an isotemporal substitution model
Association between perceived neighborhood environment, sedentary behavior, walking, and moderate-to-vigorous physical activity and frailty: an isotemporal substitution model Open
Introduction With the rapid increases of older population and growing demand for longevity worldwide, frailty has become a major hurdle to sustaining healthy aging. As residential areas are the primary domains of mobility for older adults,…
View article: Erythrocyte levels of n-3 polyunsaturated fatty acids and incidence of frailty after a 6-year follow-up: the Korean frailty and aging cohort study
Erythrocyte levels of n-3 polyunsaturated fatty acids and incidence of frailty after a 6-year follow-up: the Korean frailty and aging cohort study Open
Previous studies have shown that the blood levels of n-3 polyunsaturated fatty acids (PUFA) are inversely associated with the prevalence of frailty, but associations with frailty incidence remain unknown. We examined the hypothesis that th…
View article: Prevalence and Fall Risk of Sarcopenia Based on the 2023 Korean Working Group on Sarcopenia Criteria
Prevalence and Fall Risk of Sarcopenia Based on the 2023 Korean Working Group on Sarcopenia Criteria Open
Background and Objectives: Sarcopenia is a major risk factor for falls in older adults. The 2023 Korean Working Group on Sarcopenia (KWGS) introduced revised definitions, including functional sarcopenia, which considers low strength and pe…
View article: Predicting cognitive frailty in community-dwelling older adults: a machine learning approach based on multidomain risk factors
Predicting cognitive frailty in community-dwelling older adults: a machine learning approach based on multidomain risk factors Open
Cognitive frailty (CF), a clinical syndrome involving both physical frailty (PF) and impaired cognition (IC), is associated with adverse health outcomes in older adults. This study aimed to identify key predictors of CF and develop a machi…
View article: The association between stereoscopic vision and cognitive function on community-dwelling older adults: a cross-sectional study
The association between stereoscopic vision and cognitive function on community-dwelling older adults: a cross-sectional study Open
Background Visual impairment is associated with cognitive dysfunction in older adults; however, a relationship between stereopsis and cognitive function remains unclear. This study aimed to investigate the association between stereopsis an…
View article: Plasma Leukocyte Cell-Derived Chemotaxin-2 as a Risk Factor of Sarcopenia: Korean Frailty and Aging Cohort Study
Plasma Leukocyte Cell-Derived Chemotaxin-2 as a Risk Factor of Sarcopenia: Korean Frailty and Aging Cohort Study Open
Background/Objective: Leukocyte cell-derived chemotaxin-2 (LECT2), a hepatokine, is implicated in non-alcoholic fatty liver disease (NAFLD). Although NAFLD and sarcopenia are closely linked, the relationship between plasma LECT2 levels and…
View article: The association between stereoscopic vision and cognitive function on community-dwelling older adults: a cross-sectional study
The association between stereoscopic vision and cognitive function on community-dwelling older adults: a cross-sectional study Open
Background: Visual impairment is associated with cognitive dysfunction in older adults; however, a relationship between stereopsis and cognitive function remains unclear. This study aimed to investigate the association between stereopsis a…
View article: Association between fish intake and incidence of sarcopenia in community-dwelling older adults after a 6-year follow-up: the Korean frailty and aging cohort study
Association between fish intake and incidence of sarcopenia in community-dwelling older adults after a 6-year follow-up: the Korean frailty and aging cohort study Open
Previous studies have suggested beneficial effects of n-3 polyunsaturated fatty acids on sarcopenia. However, the associations of dietary fish intake with the prevalence of sarcopenia are inconsistent, and those with the incidence of sarco…
View article: Comparison of bioelectrical impedance analysis and dual-energy X-ray absorptiometry for the diagnosis of sarcopenia in the older adults with metabolic syndrome: equipment-specific equation development
Comparison of bioelectrical impedance analysis and dual-energy X-ray absorptiometry for the diagnosis of sarcopenia in the older adults with metabolic syndrome: equipment-specific equation development Open
Objective Metabolic syndrome (MetS) and sarcopenia together pose significant health risks, increasing frailty, falls, and fractures in older adults. This study compared muscle mass measurements obtained using two different dual-energy X-ra…
View article: Association between number of functional teeth and physical function among community-dwelling older adults: Korean Frailty and Aging Cohort Study
Association between number of functional teeth and physical function among community-dwelling older adults: Korean Frailty and Aging Cohort Study Open
Background Functional teeth are important for maintaining appropriate masticatory function and nutritional intake, affecting physical function in older adults. This study aimed to evaluate the association between number of functional teeth…
View article: LONGITUDINAL TRANSITIONS IN FRAILTY STATES OVER SIX-YEAR FOLLOW-UP: RESULTS FROM THE KFACS
LONGITUDINAL TRANSITIONS IN FRAILTY STATES OVER SIX-YEAR FOLLOW-UP: RESULTS FROM THE KFACS Open
The longitudinal nature of frailty reveals its dynamic process through transitions of frailty states over time. However, the transitions between frailty states, including their progression and reversibility, remain unclear in Korea. We inv…
View article: Mid‐upper arm circumference as a screening tool for identifying physical frailty in community‐dwelling older adults: The Korean Frailty and Aging Cohort Study
Mid‐upper arm circumference as a screening tool for identifying physical frailty in community‐dwelling older adults: The Korean Frailty and Aging Cohort Study Open
Aims Frailty in older adults is influenced by various factors, such as poor nutritional status. Mid‐upper arm circumference (MUAC) is a validated, simple, and non‐invasive tool for assessing nutritional status. Despite its potential, no st…
View article: Efficacy of a combined exercise and nutrition intervention study for outpatients with possible sarcopenia in community-based primary care clinics (ENdSarC): study protocol for a multicenter single-blinded randomized controlled trial
Efficacy of a combined exercise and nutrition intervention study for outpatients with possible sarcopenia in community-based primary care clinics (ENdSarC): study protocol for a multicenter single-blinded randomized controlled trial Open
This trial was prospectively registered at ClinicalTrials.gov on September 16, 2023 (registration number: NCT06049914).
View article: MicroRNAs as commonly expressed biomarkers for sarcopenia and frailty: A systematic review
MicroRNAs as commonly expressed biomarkers for sarcopenia and frailty: A systematic review Open
In this systematic review, we highlight the potential of shared miRNAs that exhibit consistent expression patterns as biomarkers for the early diagnosis and progression assessment of both sarcopenia and frailty.
View article: Circulating small non-coding RNA profiling for identification of older adults with low muscle strength and physical performance: A preliminary study
Circulating small non-coding RNA profiling for identification of older adults with low muscle strength and physical performance: A preliminary study Open
The expression of circulating small ncRNAs were comprehensively characterized, revealing distinct signatures in older adults with both low muscle strength and physical performance compared to normal individuals. Although preliminary, this …
View article: Dietary patterns and intrinsic capacity in older adults: a 6-year prospective cohort study
Dietary patterns and intrinsic capacity in older adults: a 6-year prospective cohort study Open
Dietary patterns (variety of healthy foods) were positively associated with changes in IC scores and their sub-domains in older adults.
View article: The Association of Free Testosterone with Sarcopenic Obesity in Community-Dwelling Older Men: A Cross-Sectional Study
The Association of Free Testosterone with Sarcopenic Obesity in Community-Dwelling Older Men: A Cross-Sectional Study Open
Background and Objectives: Sarcopenic obesity, a clinical condition coexisting with obesity and sarcopenia, is associated with a high risk of functional impairment, reduced quality of life, and increased mortality. A decline in age-related…
View article: The roles of health literacy and social support in the association between smartphone ownership and frailty in older adults: a moderated mediation model
The roles of health literacy and social support in the association between smartphone ownership and frailty in older adults: a moderated mediation model Open
Background Understanding the role of smartphones to promote the health status of older adults is important in the digital society. Little is known about the effects of having smartphones on physical frailty despite its positive effect on t…
View article: The Effect of Psychological Resilience on Cognitive Decline in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
The Effect of Psychological Resilience on Cognitive Decline in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study Open
Background: Chronic stress is associated with an increased risk of cognitive impairment and Alzheimer’s disease. This study aimed to assess whether better coping with stress, as assessed using the Brief Resilience Scale (BRS), is associate…