Min‐Sik Kim
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View article: Bronchoalveolar lavage proteomics in exacerbation of bronchiectasis
Bronchoalveolar lavage proteomics in exacerbation of bronchiectasis Open
The bronchoalveolar lavage fluid protein expression in patients in the exacerbation status of bronchiectasis was significantly different from that in patients in the stable status, indicating that neutrophil degranulation and C-type lectin…
View article: On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases
On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases Open
Bronchoalveolar lavage fluid (BALF) has long been used for diagnosing various lung diseases through its cellular components. However, the clinical utility of biomolecules in the BALF remains largely unexplored. Recently, mass spectrometry‐…
View article: Bronchoalveolar Lavage Proteomics in Acute Exacerbation of Bronchiectasis
Bronchoalveolar Lavage Proteomics in Acute Exacerbation of Bronchiectasis Open
Background: The molecular pathophysiology underlying the development of bronchiectasis with acute exacerbation at the proteomic level has not been clarified using bronchoalveolar lavage fluid samples. This study aimed to evaluate the bronc…
View article: Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment
Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment Open
Non-small cell lung cancer (NSCLC) is histologically classified into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LSCC). However, some tumors are histologically ambiguous and other pathophysiological features or microenviro…
View article: RBP4 functions as an antagonistic ligand of orphan DR6
RBP4 functions as an antagonistic ligand of orphan DR6 Open
Summary Death receptor (DR) is a unique transmembrane receptor mediating extrinsic factor-induced programmed cell death pathways. For most DRs, the regulatory mechanism has been revealed to involve agonistic death ligand (e.g., TRAIL, TNF-…
View article: Deciphering Cancer Complexity: Integrative Proteogenomics and Proteomics Approaches for Biomarker Discovery
Deciphering Cancer Complexity: Integrative Proteogenomics and Proteomics Approaches for Biomarker Discovery Open
Proteomics has revolutionized the field of cancer biology because the use of a large number of in vivo (SILAC), in vitro (iTRAQ, ICAT, TMT, stable-isotope Dimethyl, and 18O) labeling techniques or label-free methods (spectral counting or p…
View article: Exploring the feasibility of a single-protoplast proteomic analysis
Exploring the feasibility of a single-protoplast proteomic analysis Open
Background Recent advances in high-resolution mass spectrometry have now enabled the study of proteomes at the single-cell level, offering the potential to unveil novel aspects of cellular processes. Remarkably, there has been no prior att…
View article: Pan-cancer proteogenomic landscape of whole-genome doubling reveals putative therapeutic targets in various cancer types
Pan-cancer proteogenomic landscape of whole-genome doubling reveals putative therapeutic targets in various cancer types Open
Background Whole-genome doubling (WGD) is prevalent in cancer and drives tumor development and chromosomal instability. Driver mutations in mitotic cell cycle genes and cell cycle upregulation have been reported as the major molecular unde…
View article: Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability
Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability Open
As research into the complexities of cancer biology deepens, the integration of multi-omics analyses has emerged as a powerful approach to unravel the complex molecular basis of cancers. However, challenges related to sample availability, …
View article: A comparative study of ammonia solubility in imidazolium-based ionic liquids with different structural compositions
A comparative study of ammonia solubility in imidazolium-based ionic liquids with different structural compositions Open
Four imidazolium-based ionic liquids (ILs) with two cations 1-pentyl-3-butylimidazolium [PBIM]+ and 1-benzyl-3-butylimidazolium tetrafluoroborate [BzBIM]+, and two anions tetrafluoroborate (BF4-) and trifluoromethanesulfonate (OTf-) were s…
View article: Modified AWSSDR method for frequency-dependent reverberation time estimation*
Modified AWSSDR method for frequency-dependent reverberation time estimation* Open
Reverberation time (T60) is a typical acoustic parameter that provides information about reverberation. Since the impacts of reverberation vary depending on the frequency bands even in the same space, frequency-dependent (FD) T60, which of…
View article: Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder
Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder Open
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired social behavior and communication, repetitive behaviors, and restricted interests. In addition to genetic factors, environmental factors such as prena…
View article: Supplementary Figure 2 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 2 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Selection criteria used to narrow the proteins identified in the screen to those shown in this study.
View article: Supplementary Figure 1 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 1 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Venn diagram showing overlap of proteins identified in 3 patients after the SASI screen.
View article: Supplementary Figure 5 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 5 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
MYPT1 and PSMC5 expression in 3 different subtypes (basal, HER-2 positive and ER positive) of breast cancer.
View article: Data from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Data from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Less than 6% of patients survive beyond the fifth year due to inadequate early diagnostics and ineffective treatment options. Our laboratory has d…
View article: Data from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Data from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Less than 6% of patients survive beyond the fifth year due to inadequate early diagnostics and ineffective treatment options. Our laboratory has d…
View article: Supplementary Figure 5 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 5 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
MYPT1 and PSMC5 expression in 3 different subtypes (basal, HER-2 positive and ER positive) of breast cancer.
View article: Supplementary Figure 1 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 1 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Venn diagram showing overlap of proteins identified in 3 patients after the SASI screen.
View article: Supplementary Figure 4 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 4 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Additional immunohistochemical validation showing PSMC5, MYPT1 and TFRC expression in an independent set of pancreatic cancers.
View article: Supplementary Figure 3 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 3 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Western blots showing the antibody responses for PSMC5, MYPT1 and TFRC in patients with greater than and less than 3 years disease free survival
View article: Supplementary Figure 2 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 2 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Selection criteria used to narrow the proteins identified in the screen to those shown in this study.
View article: Supplementary Figure 4 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 4 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Additional immunohistochemical validation showing PSMC5, MYPT1 and TFRC expression in an independent set of pancreatic cancers.
View article: Supplementary Figure 3 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
Supplementary Figure 3 from Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer Open
Western blots showing the antibody responses for PSMC5, MYPT1 and TFRC in patients with greater than and less than 3 years disease free survival
View article: Porcine Reproductive and Respiratory Syndrome Virus Engineered by Serine Substitution on the 44th Amino Acid of GP5 Resulted in a Potential Vaccine Candidate with the Ability to Produce High Levels of Neutralizing Antibody
Porcine Reproductive and Respiratory Syndrome Virus Engineered by Serine Substitution on the 44th Amino Acid of GP5 Resulted in a Potential Vaccine Candidate with the Ability to Produce High Levels of Neutralizing Antibody Open
N-linked glycans covering GP5 neutralizing epitopes of porcine reproductive and respiratory syndrome virus (PRRSV) have been proposed to act as a sheath blocking the production of neutralizing antibodies. Herein, we genetically engineered …