Sewon Kang
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View article: Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease
Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease Open
View article: 0599 Plastic associated endocrine disruptors reduce nicastrin protein and potentiate inflammation in hidradenitis suppurativa
0599 Plastic associated endocrine disruptors reduce nicastrin protein and potentiate inflammation in hidradenitis suppurativa Open
View article: Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial
Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial Open
Background/Objectives: Oxidative stress plays a pivotal role in skin aging and carcinogenesis. Phytochemicals such as sulforaphane (SF, from broccoli sprouts or seeds) or curcumin (CUR, from turmeric) can be highly protective against this …
View article: Differences in clinical features and risk factors for striae distensae in Black and White women
Differences in clinical features and risk factors for striae distensae in Black and White women Open
View article: Association between meeting the 24-hour movement guidelines and cardiometabolic syndrome in Korean adults
Association between meeting the 24-hour movement guidelines and cardiometabolic syndrome in Korean adults Open
View article: Channels of ESG Pressure: A Comprehensive Approach
Channels of ESG Pressure: A Comprehensive Approach Open
View article: The use of ectopic volar fibroblasts to modify skin identity
The use of ectopic volar fibroblasts to modify skin identity Open
Skin identity is controlled by intrinsic features of the epidermis and dermis and their interactions. Modifying skin identity has clinical potential, such as the conversion of residual limb and stump (nonvolar) skin of amputees to pressure…
View article: Retinoids in the treatment of photoageing: A histological study of topical retinoid efficacy in black skin
Retinoids in the treatment of photoageing: A histological study of topical retinoid efficacy in black skin Open
Background Photoageing describes complex cutaneous changes that occur due to chronic exposure to solar ultraviolet radiation (UVR). The ‘gold standard’ for the treatment of photoaged white skin is all‐ trans retinoic acid (ATRA); however, …
View article: Single-Cell RNA Sequencing Reveals Dysregulated POSTN+WNT5A+ Fibroblast Subclusters in Prurigo Nodularis
Single-Cell RNA Sequencing Reveals Dysregulated POSTN+WNT5A+ Fibroblast Subclusters in Prurigo Nodularis Open
Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly understood pathogenesis. We performed single-cell transcriptomic profiling of 28,695 lesional and nonlesional PN cells. Lesional PN has increased dysr…
View article: Implications for cumulative and prolonged clinical improvement induced by cross‐linked hyaluronic acid: An in vivo biochemical/microscopic study in humans
Implications for cumulative and prolonged clinical improvement induced by cross‐linked hyaluronic acid: An in vivo biochemical/microscopic study in humans Open
In photoaged human skin, type I collagen fragmentation impairs dermal extracellular matrix (ECM) integrity, resulting in collapsed/contracted fibroblasts with reduced type I procollagen synthesis. Injections of cross‐linked hyaluronic acid…
View article: Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis
Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis Open
Background: Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly understood pathogenesis. Methods: We performed single-cell transcriptomic profiling of 28,695 lesional and non-lesional PN cells. Results:…
View article: Untitled Document
Untitled Document Open
Background: Erythroderma is characterized by diffuse redness and inflammation involving a majority of the skin. The pathophysiology of erythroderma is heterogeneous, with many cases of unknown etiology and variable treatment response. For …
View article: Atrophic acne scars, including scars less than 1.5 mm, may undergo spontaneous regression: A cohort study
Atrophic acne scars, including scars less than 1.5 mm, may undergo spontaneous regression: A cohort study Open
View article: A Polygenic Risk Score for Predicting Racial and Genetic Susceptibility to Prurigo Nodularis
A Polygenic Risk Score for Predicting Racial and Genetic Susceptibility to Prurigo Nodularis Open
View article: N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma
N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma Open
View article: Sex‐specific differences in oxidative stress markers and collagen expression in perioral skin wrinkling
Sex‐specific differences in oxidative stress markers and collagen expression in perioral skin wrinkling Open
Wrinkling is the hallmark of skin ageing. We previously reported that perioral wrinkling is more severe in females; however, the molecular basis is unknown. This study assessed sex differences in the molecular expression of key ageing regu…
View article: Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis
Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis Open
Prurigo nodularis (PN) is an intensely pruritic, chronic inflammatory skin disease that disproportionately affects black patients. However, the pathogenesis of PN is poorly understood. We performed single-cell transcriptomic profiling, lig…
View article: Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function
Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function Open
View article: Clinical and molecular change induced by repeated low‐dose visible light exposure in both light‐skinned and dark‐skinned individuals
Clinical and molecular change induced by repeated low‐dose visible light exposure in both light‐skinned and dark‐skinned individuals Open
Background Visible light (VL) is known to induce pigmentation in dark‐skinned individuals and immediate erythema in light‐skinned individuals. However, the effects of accumulated low‐dose VL exposure across skin types are not well establis…
View article: Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage
Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage Open
ClinicalTrials.gov Identifier: NCT01283464.
View article: Cutaneous Toxicities Associated with Immune Checkpoint Inhibitors: An Observational, Pharmacovigilance Study
Cutaneous Toxicities Associated with Immune Checkpoint Inhibitors: An Observational, Pharmacovigilance Study Open
View article: UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner
UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner Open
It is currently thought that UVB radiation drives photoaging of the skin primarily by generating ROS. In this model, ROS purportedly activates activator protein-1 to upregulate MMPs 1, 3, and 9, which then degrade collagen and other extrac…
View article: Cutaneous Transcriptomics Identifies Fibroproliferative and Neurovascular Gene Dysregulation in Prurigo Nodularis Compared with Psoriasis and Atopic Dermatitis
Cutaneous Transcriptomics Identifies Fibroproliferative and Neurovascular Gene Dysregulation in Prurigo Nodularis Compared with Psoriasis and Atopic Dermatitis Open
View article: Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans
Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans Open
View article: Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages
Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages Open
View article: Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation
Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation Open
View article: 665 Matrix metalloproteinase 2 is a potential mediator of retinoid efficacy in photoaging
665 Matrix metalloproteinase 2 is a potential mediator of retinoid efficacy in photoaging Open
View article: 554 Cluster analysis of circulating plasma biomarkers in prurigo nodularis reveals a distinct systemic inflammatory signature in African Americans
554 Cluster analysis of circulating plasma biomarkers in prurigo nodularis reveals a distinct systemic inflammatory signature in African Americans Open
View article: 683 Xerosis cutis and its association with chronic inflammatory illnesses
683 Xerosis cutis and its association with chronic inflammatory illnesses Open
View article: Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization
Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization Open