Won‐Jin Moon
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View article: Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial
Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial Open
Introduction: This multicenter, double-blind, placebo-controlled trial, commissioned by South Korea’s Ministry of Food and Drug Safety, evaluated the effect of oxiracetam for preventing post-stroke cognitive impairment (PSCI) and explored …
View article: Comparison of orbital structures between age-related distance esotropia and acute acquired concomitant esotropia
Comparison of orbital structures between age-related distance esotropia and acute acquired concomitant esotropia Open
Purpose To compare orbital magnetic resonance imaging (MRI) findings of age-related distance esotropia (ARDE) with those of age-matched healthy controls and acute acquired concomitant esotropia (AACE) patients. Methods Coronal MRI scans of…
View article: Associations Between Cortical Iron Accumulation and Memory in Patients With Amnestic Mild Cognitive Impairment and in Cognitively Normal Individuals
Associations Between Cortical Iron Accumulation and Memory in Patients With Amnestic Mild Cognitive Impairment and in Cognitively Normal Individuals Open
Background and Purpose Brain iron accumulation is recognized as a cause and therapeutic target in Alzheimer's disease (AD). We investigated the differences in both volume and iron accumulation between cognitively normal (CN) older adults a…
View article: Selective phase growth of ultra-smooth Ti2O3 and TiO2 thin films at low growth temperature controlled by the oxygen partial pressure
Selective phase growth of ultra-smooth Ti2O3 and TiO2 thin films at low growth temperature controlled by the oxygen partial pressure Open
The selective phase growth of Ti-based oxide thin films on sapphire substrates is crucial in controlling the electronic properties, such as the insulator-to-metal transition (IMT). Thin films are generally prepared by pulsed laser depositi…
View article: Diagnosis and Treatment of Alzheimer’s Disease: Current Update
Diagnosis and Treatment of Alzheimer’s Disease: Current Update Open
Alzheimer's disease, one of the most common causes of dementia, places a significant socioeconomic burden on aging societies. Encouragingly, extensive research on this neurocognitive disorder has finally uncovered the underpinnings of its …
View article: Amyloid-Related Imaging Abnormalities in Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer’s Disease: Expert Recommendation for Standard MRI Protocol
Amyloid-Related Imaging Abnormalities in Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer’s Disease: Expert Recommendation for Standard MRI Protocol Open
The introduction of anti-amyloid therapies for Alzheimer's disease (AD), such as lecanemab (Lequembi®), which was recently approved in Korea, necessitates careful monitoring for amyloid-related imaging abnormalities (ARIA) using brain MRI.…
View article: Predicting Patient Satisfaction with Bimaxillary Surgery Outcomes: A Functional MRI Study of Neural Responses to Self-Images
Predicting Patient Satisfaction with Bimaxillary Surgery Outcomes: A Functional MRI Study of Neural Responses to Self-Images Open
Distinct neural activation patterns were observed when viewing preoperative and postoperative self-images, suggesting that fMRI could serve as a potential tool for predicting patient satisfaction with surgical outcomes. The activated brain…
View article: Quantitative Analysis of Choroid Plexus Enlargement in Alzheimer’s Dementia: A Study of Automated Volumetric Technique
Quantitative Analysis of Choroid Plexus Enlargement in Alzheimer’s Dementia: A Study of Automated Volumetric Technique Open
Background Choroid plexus enlargement is implicated in the exacerbation of cognitive impairments characteristic of Alzheimer’s dementia (AD). Manual volumetric assessment by radiologists, while accurate, is impractical for large‐scale appl…
View article: Quantitative Analysis of Choroid Plexus Enlargement in Alzheimer's Dementia: A Study of Automated Volumetric Technique
Quantitative Analysis of Choroid Plexus Enlargement in Alzheimer's Dementia: A Study of Automated Volumetric Technique Open
Background Choroid plexus enlargement is implicated in the exacerbation of cognitive impairments characteristic of Alzheimer’s dementia (AD). Manual volumetric assessment by radiologists, while accurate, is impractical for large‐scale appl…
View article: Volume and Permeability of White Matter Hyperintensity on Cognition: A <scp>DCE</scp> Imaging Study of an Older Cohort With and Without Cognitive Impairment
Volume and Permeability of White Matter Hyperintensity on Cognition: A <span>DCE</span> Imaging Study of an Older Cohort With and Without Cognitive Impairment Open
Background The impact of blood–brain barrier (BBB) leakage on white matter hyperintensity (WMH) subtypes (location) and its association with clinical factors and cognition remains unclear. Purpose To investigate the relationship between WM…
View article: Evaluating impaired consciousness after acquired brain injury using a virtual-reality-based eye-tracking system
Evaluating impaired consciousness after acquired brain injury using a virtual-reality-based eye-tracking system Open
Background Virtual reality (VR) can provide an experimental basis for inferring consciousness using information obtained from the responses of persons with disorders of consciousness (DOC) to denoised exogenous stimuli. Although integratio…
View article: Deep Cascade of Convolutional Neural Networks for Quantification of Enlarged Perivascular Spaces in the Basal Ganglia in Magnetic Resonance Imaging
Deep Cascade of Convolutional Neural Networks for Quantification of Enlarged Perivascular Spaces in the Basal Ganglia in Magnetic Resonance Imaging Open
In this paper, we present a cascaded deep convolution neural network (CNN) for assessing enlarged perivascular space (ePVS) within the basal ganglia region using T2-weighted MRI. Enlarged perivascular spaces (ePVSs) are potential biomarker…
View article: A study of the personality trait-focused digital mental health intervention
A study of the personality trait-focused digital mental health intervention Open
Introduction Mental healthcare services that address a variety of primary complaints which are highly related to maladaptive personality traits among the general population are important to prevent developing psychiatric disorders. Objecti…
View article: Unpaired deep learning for pharmacokinetic parameter estimation from dynamic contrast-enhanced MRI without AIF measurements
Unpaired deep learning for pharmacokinetic parameter estimation from dynamic contrast-enhanced MRI without AIF measurements Open
DCE-MRI provides information about vascular permeability and tissue perfusion through the acquisition of pharmacokinetic parameters. However, traditional methods for estimating these pharmacokinetic parameters involve fitting tracer kineti…
View article: Effects of Oxiracetam and Physical Activity in Preventing Post-Stroke Cognitive Decline: A Randomized Controlled Trial
Effects of Oxiracetam and Physical Activity in Preventing Post-Stroke Cognitive Decline: A Randomized Controlled Trial Open
Introduction: This trial, conducted according to the request of the Korean Ministry of Food and Drug Safety, investigated the potential of oxiracetam in mitigating post-stroke cognitive decline, and whether physical activity could augment …
View article: Blood-brain barrier breakdown is linked to tau pathology and neuronal injury in a differential manner according to amyloid deposition
Blood-brain barrier breakdown is linked to tau pathology and neuronal injury in a differential manner according to amyloid deposition Open
The blood-brain barrier (BBB) breakdown has been suggested as an early marker for Alzheimer's disease (AD); yet the relationship between BBB breakdown and AD-specific biomarkers based on the amyloid/tau/neurodegeneration framework is not c…
View article: Unpaired Deep Learning for Pharmacokinetic Parameter Estimation from Dynamic Contrast-Enhanced MRI
Unpaired Deep Learning for Pharmacokinetic Parameter Estimation from Dynamic Contrast-Enhanced MRI Open
DCE-MRI provides information about vascular permeability and tissue perfusion through the acquisition of pharmacokinetic parameters. However, traditional methods for estimating these pharmacokinetic parameters involve fitting tracer kineti…
View article: Correlations between H2 Permeation and Physical/Mechanical Properties in Ethylene Propylene Diene Monomer Polymers Blended with Carbon Black and Silica Fillers
Correlations between H2 Permeation and Physical/Mechanical Properties in Ethylene Propylene Diene Monomer Polymers Blended with Carbon Black and Silica Fillers Open
H2 permeation in peroxide-crosslinked EPDM blended with carbon black (CB) and silica fillers was studied at pressures ranging from 1.2 MPa to 90 MPa via the volumetric analysis technique. H2 uptake in the CB-filled EPDM revealed dual-sorpt…
View article: Diagnostic Tools for Alzheimer’s Disease: A Narrative Review Based on Our Own Research Experience
Diagnostic Tools for Alzheimer’s Disease: A Narrative Review Based on Our Own Research Experience Open
Alzheimer's disease (AD), one of the most representative neurodegenerative diseases, has diverse neurobiological and pathophysiological mechanisms. Treatment strategies targeting a single mechanism have repeated faced failures because the …
View article: Cortical Iron Accumulation as an Imaging Marker for Neurodegeneration in Clinical Cognitive Impairment Spectrum: A Quantitative Susceptibility Mapping Study
Cortical Iron Accumulation as an Imaging Marker for Neurodegeneration in Clinical Cognitive Impairment Spectrum: A Quantitative Susceptibility Mapping Study Open
Iron deposition in the cortex, as measured by QSMnet+, was higher in patients with AD and MCI than in NC participants. Iron deposition in the cingulate and insular cortices may be an early imaging marker of cognitive impairment related neu…
View article: H2 Uptake and Diffusion Characteristics in Sulfur-Crosslinked Ethylene Propylene Diene Monomer Polymer Composites with Carbon Black and Silica Fillers after High-Pressure Hydrogen Exposure Reaching 90 MPa
H2 Uptake and Diffusion Characteristics in Sulfur-Crosslinked Ethylene Propylene Diene Monomer Polymer Composites with Carbon Black and Silica Fillers after High-Pressure Hydrogen Exposure Reaching 90 MPa Open
We investigated the influence of two fillers—CB (carbon black) and silica—on the H2 permeation of EPDM polymers crosslinked with sulfur in the pressure ranges 1.2–90 MPa. H2 uptake in the CB-blended EPDM revealed dual sorption (Henry’s law…
View article: Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial
Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial Open
Neuromelanin (NM)-sensitive MRI using a magnetization transfer (MT)-prepared T1-weighted sequence has been suggested as a tool to visualize NM contents in the brain. In this study, a new NM-sensitive imaging method, sandwichNM, is proposed…
View article: Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging
Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging Open
Background Recent advances in rapid imaging techniques necessitate the reconsideration of the optimal imaging delay time for contrast-enhanced T1-weighted imaging. The aim of our study was to determine the optimal contrast-enhanced T1-weig…
View article: Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum
Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum Open
Background Mounting evidence suggests that the choroid plexus (CP) plays an important role in the pathophysiology of Alzheimer disease (AD), but its imaging profile in cognitive impairment remains unclear. Purpose To evaluate CP volume, pe…
View article: Optimal MRI time determination for intracerebral metastases and primary brain tumors after injecting a standard gadobutrol dose: Evidence from a dynamic contrast-enhanced imaging study
Optimal MRI time determination for intracerebral metastases and primary brain tumors after injecting a standard gadobutrol dose: Evidence from a dynamic contrast-enhanced imaging study Open
Background: Recent advances in rapid imaging techniques necessitate the reconsideration of the optimal imaging delay time for contrast-enhanced T1-weighted imaging. The aim of our study was to determine the optimal contrast-enhanced T1-wei…