Woo Yang Pyun
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View article: Nutrient availability dictates cancer metabolism-based therapeutic responses of non-oncology drugs
Nutrient availability dictates cancer metabolism-based therapeutic responses of non-oncology drugs Open
Metabolic deregulation is a major hallmark of cancer, therefore, interventions that modify tumor nutrient availability are considered attractive adjuvants for improving clinical outcomes for cancer patients. Much work remains, however, in …
View article: Cell competition reprograms adherent-suspension plasticity in disseminated tumor cells
Cell competition reprograms adherent-suspension plasticity in disseminated tumor cells Open
Cell competition within the primary tumor drives tumor growth by promoting the uncontrolled proliferation of winner cells and eliminating loser cells by sensing cell fitness. However, the mechanism of how cell competition confers the loser…
View article: Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets Open
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells. Well-known…