Wouter Bakker
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View article: Characterising a HepaRG liver microphysiological system for individual bile acid secretion and chemical induced disruptions
Characterising a HepaRG liver microphysiological system for individual bile acid secretion and chemical induced disruptions Open
Liver microphysiological systems (MPS) have gained increasing attention as human-relevant models for chemical safety assessments, particularly for studies with defined endpoints, such as cholestatic injury. In this study, we built upon a p…
View article: Tissue distribution of endogenously formed and orally administered low molecular mass advanced glycation end-products in rats.
Tissue distribution of endogenously formed and orally administered low molecular mass advanced glycation end-products in rats. Open
This study quantified the tissue distribution in rats of four exogenously administered and endogenously formed low molecular mass (LMM) AGEs, including glycolic acid-lysine-amide (GALA), N-ε-(carboxyethyl)lysine (CEL), N-ε-(carboxymethyl)l…
View article: Organophosphate pesticides modulate gut microbiota and influence bile acid metabolism in an in vitro fermentation model
Organophosphate pesticides modulate gut microbiota and influence bile acid metabolism in an in vitro fermentation model Open
Widely used organophosphate (OP) pesticides are shown to be of acute neurotoxicity; however, OP residues were frequently reported to be present in our living surroundings, posing a risk to human health. In this study, the effects of OP pes…
View article: Antibiotics reduce intestinal bile acid reuptake in an in vitro model system
Antibiotics reduce intestinal bile acid reuptake in an in vitro model system Open
Enterohepatic circulation of bile acids is a highly efficient process that is important for bile acid homeostasis. The aim of the present study was to characterize the impact of a series of antibiotics (lincomycin, streptomycin, vancomycin…
View article: Evaluation of a Pbk Model Based Approach for Wildlife Biomonitoring of Exposure to the Neonicotinoid Pesticide Imidacloprid Using Wild Captured Wood Mice (Apodemus Sylvaticus)
Evaluation of a Pbk Model Based Approach for Wildlife Biomonitoring of Exposure to the Neonicotinoid Pesticide Imidacloprid Using Wild Captured Wood Mice (Apodemus Sylvaticus) Open
View article: Evaluation of a Pbk Model Based Approach for Wildlife Biomonitoring of Exposure to the Fungicide Carbendazim Using Wild Captured Wood Mice (Apodemus Sylvaticus)
Evaluation of a Pbk Model Based Approach for Wildlife Biomonitoring of Exposure to the Fungicide Carbendazim Using Wild Captured Wood Mice (Apodemus Sylvaticus) Open
View article: An integrated proteomics and metabolomics analysis of methylglyoxal-induced neurotoxicity in a human neuroblastoma cell line
An integrated proteomics and metabolomics analysis of methylglyoxal-induced neurotoxicity in a human neuroblastoma cell line Open
View article: A simple<i>in vitro</i>fermentation model to detect alterations in gut microbiota-dependent bile acid profiles
A simple<i>in vitro</i>fermentation model to detect alterations in gut microbiota-dependent bile acid profiles Open
A previous in vivo study showed that lincosamide antibiotics (lincomycin and clindamycin) could induce changes in the gut bacterial community, leading to significant changes in fecal bile acid profiles. Herein, our aim is to develop an ani…
View article: Proteomics-based identification of biomarkers reflecting endogenous and exogenous exposure to the advanced glycation end product precursor methylglyoxal in SH-SY5Y human neuroblastoma cells
Proteomics-based identification of biomarkers reflecting endogenous and exogenous exposure to the advanced glycation end product precursor methylglyoxal in SH-SY5Y human neuroblastoma cells Open
Methylglyoxal (MGO), a highly reactive precursor of advanced glycation end products, is endogenously produced and prevalent in various food products. This study aimed to characterize protein modifications in SH-SY5Y human neuroblastoma cel…
View article: Absorption and intracellular accumulation of food-borne dicarbonyl precursors of advanced glycation end-product in a Caco-2 human cell transwell model
Absorption and intracellular accumulation of food-borne dicarbonyl precursors of advanced glycation end-product in a Caco-2 human cell transwell model Open
This study aimed to better understand whether and how the reactive 1,2-dicarbonyl precursors of advanced glycation end products (AGEs), glyoxal (GO) and methylglyoxal (MGO), cross the intestinal barrier by studying their transport in the i…
View article: Discrimination of Lipogenic or Glucogenic Diet Effects in Early-Lactation Dairy Cows Using Plasma Metabolite Abundances and Ratios in Combination with Machine Learning
Discrimination of Lipogenic or Glucogenic Diet Effects in Early-Lactation Dairy Cows Using Plasma Metabolite Abundances and Ratios in Combination with Machine Learning Open
During early lactation, dairy cows have a negative energy balance since their energy demands exceed their energy intake: in this study, we aimed to investigate the association between diet and plasma metabolomics profiles and how these rel…
View article: Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in <i>Caenorhabditis elegans</i> and Their Comparative Potency
Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in <i>Caenorhabditis elegans</i> and Their Comparative Potency Open
The nematode Caenorhabditis elegans is a valuable model for ecotoxicological research, yet limited attention has been given to understanding how it absorbs, distributes, metabolizes, and excretes chemicals. This is crucial for C.…
View article: Organophosphate Pesticides Modulate Gut Microbiota and Influence Bile Acid Metabolism in an in Vitro Fermentation Model
Organophosphate Pesticides Modulate Gut Microbiota and Influence Bile Acid Metabolism in an in Vitro Fermentation Model Open
View article: Evaluation of a Pbk Model Based Approach for Wildlife Biomonitoring of Exposure to the Fungicide Carbendazim Using Wild Captured Wood Mice (Apodemus Sylvaticus)
Evaluation of a Pbk Model Based Approach for Wildlife Biomonitoring of Exposure to the Fungicide Carbendazim Using Wild Captured Wood Mice (Apodemus Sylvaticus) Open
View article: Comparison of the methylglyoxal scavenging effects of kaempferol and glutathione and the consequences for the toxicity of methylglyoxal in SH-SY5Y cells
Comparison of the methylglyoxal scavenging effects of kaempferol and glutathione and the consequences for the toxicity of methylglyoxal in SH-SY5Y cells Open
This study aimed to characterize the methylglyoxal (MGO) scavenging capacity of glutathione (GSH) and kaempferol in more detail with special emphasis on the possible reversible nature of the adduct formation and their competition for MGO, …
View article: On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin
On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin Open
Purpurin is a major anthraquinone present in the roots of Rubia cordifolia (madder). Purpurin is known to activate Nrf2 (Nuclear transcription factor erythroid 2-related factor 2) EpRE (electrophile responsive element) mediated gene expres…
View article: Deoxynivalenol increases pro-inflammatory cytokine secretion and reduces primary bile acid transport in an inflamed intestinal in vitro co-culture model
Deoxynivalenol increases pro-inflammatory cytokine secretion and reduces primary bile acid transport in an inflamed intestinal in vitro co-culture model Open
View article: Ribotoxin deoxynivalenol induces taurocholic acid malabsorption in an in vitro human intestinal model
Ribotoxin deoxynivalenol induces taurocholic acid malabsorption in an in vitro human intestinal model Open
The trichothecene toxin deoxynivalenol (DON) is a ribotoxic mycotoxin that contaminates cereal-based food. DON binds to ribosomes, thereby inhibiting protein translation and activating stress mitogen-activated protein kinases (MAPK). The a…
View article: Induction of Nrf2-EpRE-mediated gene expression by hydroxyanthraquinones present in extracts from traditional Chinese medicine and herbs
Induction of Nrf2-EpRE-mediated gene expression by hydroxyanthraquinones present in extracts from traditional Chinese medicine and herbs Open
Hydroxyanthraquinones that can be present in traditional Chinese medicine (TCM) and herbal extracts have claimed beneficial intestinal effects. We examined the ability of a panel hydroxyanthraquinones, and methanolic extracts from selected…
View article: In vitro models to measure effects on intestinal deconjugation and transport of mixtures of bile acids
In vitro models to measure effects on intestinal deconjugation and transport of mixtures of bile acids Open
View article: Absorption and Accumulation of Food-Borne Free Advanced Glycation End-Product Precursors in a Caco-2 Human Cell Transwell Model
Absorption and Accumulation of Food-Borne Free Advanced Glycation End-Product Precursors in a Caco-2 Human Cell Transwell Model Open
View article: In vitro models to detect in vivo bile acid changes induced by antibiotics
In vitro models to detect in vivo bile acid changes induced by antibiotics Open
View article: Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine
Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine Open
The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by…
View article: Hepatic bile acid synthesis and secretion: Comparison of in vitro methods
Hepatic bile acid synthesis and secretion: Comparison of in vitro methods Open
View article: The Influence of Intracellular Glutathione Levels on the Induction of Nrf2-Mediated Gene Expression by α-Dicarbonyl Precursors of Advanced Glycation End Products
The Influence of Intracellular Glutathione Levels on the Induction of Nrf2-Mediated Gene Expression by α-Dicarbonyl Precursors of Advanced Glycation End Products Open
α-Dicarbonyl compounds, particularly methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), are highly reactive precursors for the formation of advanced glycation end products (AGEs). They are formed in vivo and during food proces…
View article: Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells
Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells Open
Conjugated bile acids are synthesized in liver and subsequently secreted into the intestinal lumen from which they are actively reabsorbed and transported back to liver. The efficient enterohepatic circulation of conjugated bile acids is i…
View article: The Investment Order Tool : Horticultural investment selection in Jordan and Spain June 2016 to June 2019
The Investment Order Tool : Horticultural investment selection in Jordan and Spain June 2016 to June 2019 Open
In 2015 Wageningen University & Research, Business Unit Greenhouse Horticulture gathered a group of Dutch supply industry companies around the idea of creating an investment order tool. The companies involved were the fertiliser producer S…
View article: Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket
Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket Open