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View article: A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease
A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease Open
BACKGROUND: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. METHODS…
View article: Thioredoxin 2 protects mice against experimental myocardial infarction
Thioredoxin 2 protects mice against experimental myocardial infarction Open
Graphical abstract Experimental Myocardial infarction (MI) using ligation procedure induces cardiac dysfunction, high level of ROS, inflammation, apoptosis, fibrosis and cardiomyocyte (CM) loss. AAV overexpressing human Trx-2, specifically…
View article: Thioredoxin‐1 and its mimetic peptide improve systolic cardiac function and remodeling after myocardial infarction
Thioredoxin‐1 and its mimetic peptide improve systolic cardiac function and remodeling after myocardial infarction Open
Myocardial infarction (MI) is characterized by a significant loss of cardiomyocytes (CMs), and it is suggested that reactive oxygen species (ROS) are involved in cell cycle arrest, leading to impaired CM renewal. Thioredoxin‐1 (Trx‐1) scav…
View article: A latent cardiomyocyte regeneration potential in human heart disease
A latent cardiomyocyte regeneration potential in human heart disease Open
Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospect…
View article: FUCCI-Based Live Imaging Platform Reveals Cell Cycle Dynamics and Identifies Pro-proliferative Compounds in Human iPSC-Derived Cardiomyocytes
FUCCI-Based Live Imaging Platform Reveals Cell Cycle Dynamics and Identifies Pro-proliferative Compounds in Human iPSC-Derived Cardiomyocytes Open
One of the major goals in cardiac regeneration research is to replace lost ventricular tissue with new cardiomyocytes. However, cardiomyocyte proliferation drops to low levels in neonatal hearts and is no longer efficient in compensating f…
View article: FUCCI-based live imaging platform reveals cell cycle dynamics and identifies pro-proliferative compounds in human iPSC-derived cardiomyocytes
FUCCI-based live imaging platform reveals cell cycle dynamics and identifies pro-proliferative compounds in human iPSC-derived cardiomyocytes Open
One of the major goals in cardiac regeneration research is to replace lost ventricular tissue with new cardiomyocytes. However, cardiomyocyte proliferation drops to low levels in neonatal hearts and is no longer efficient in compensating f…
View article: Identification and characterization of distinct cell cycle stages in cardiomyocytes using the FUCCI transgenic system
Identification and characterization of distinct cell cycle stages in cardiomyocytes using the FUCCI transgenic system Open
Understanding the regulatory mechanism by which cardiomyocyte proliferation transitions to endoreplication and cell cycle arrest during the neonatal period is crucial for identifying proproliferative factors and developing regenerative the…
View article: Identification and characterization of distinct cell cycle stages in cardiomyocytes using the FUCCI transgenic system
Identification and characterization of distinct cell cycle stages in cardiomyocytes using the FUCCI transgenic system Open
Understanding the regulatory mechanism by which cardiomyocyte proliferation transitions to endoreplication and cell cycle arrest during the neonatal period is crucial for identifying proproliferative factors and developing regenerative the…
View article: Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes
Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes Open
Bioelectronic interfaces employing arrays of sensors and bioactuators are promising tools for the study, repair and engineering of cardiac tissues. They are typically constructed from rigid and brittle materials processed in a cleanroom en…
View article: NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis
NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis Open
Acute viral myocarditis (VM), characterised by leukocyte infiltration and dysfunction of the heart, is an important cause of sudden cardiac death in young adults. Unfortunately, to date, the pathological mechanisms underlying cardiac failu…