Wouter F. Visser
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View article: Knowledge Distillation for Continual Learning of Biomedical Neural Fields
Knowledge Distillation for Continual Learning of Biomedical Neural Fields Open
Neural fields are increasingly used as a light-weight, continuous, and differentiable signal representation in (bio)medical imaging. However, unlike discrete signal representations such as voxel grids, neural fields cannot be easily extend…
View article: Reducing False Positives in Newborn Screening: The Role of Perinatal Factors in the Dutch NBS Program
Reducing False Positives in Newborn Screening: The Role of Perinatal Factors in the Dutch NBS Program Open
Background/Objectives: Dutch newborn screening is an important public health program designed to detect conditions early in life, enabling timely interventions that can prevent mortality, morbidity, and long-term disabilities. However, the…
View article: Determination of Nicotine Protonation State in E-Liquids by Low-Resolution Benchtop NMR Spectroscopy
Determination of Nicotine Protonation State in E-Liquids by Low-Resolution Benchtop NMR Spectroscopy Open
Over several years, e-liquids with "nicotine salts" have gained considerable popularity. These e-liquids have a low pH, at which nicotine occurs mostly in its monoprotonated form. Manufacturers usually accomplish this by the addition of an…
View article: Sensory appeal and puffing intensity of e-cigarette use: Influence of nicotine salts versus free-base nicotine in e-liquids
Sensory appeal and puffing intensity of e-cigarette use: Influence of nicotine salts versus free-base nicotine in e-liquids Open
View article: Reducing attractiveness of e-liquids: proposal for a restrictive list of tobacco-related flavourings
Reducing attractiveness of e-liquids: proposal for a restrictive list of tobacco-related flavourings Open
Objective Electronic cigarettes are addictive and harmful, and flavour is a key factor determining their abuse liability. Both adult smokers and young non-smokers like sweet and fruity flavours in particular. In order to discourage e-cigar…
View article: Sex‐specific newborn screening for <scp>X‐linked</scp> adrenoleukodystrophy
Sex‐specific newborn screening for <span>X‐linked</span> adrenoleukodystrophy Open
Males with X‐linked adrenoleukodystrophy (ALD) are at high risk for developing adrenal insufficiency and/or progressive leukodystrophy (cerebral ALD) at an early age. Pathogenic variants in ABCD1 result in elevated levels of very long‐chai…
View article: Systematic multi‐level analysis of an organelle proteome reveals new peroxisomal functions
Systematic multi‐level analysis of an organelle proteome reveals new peroxisomal functions Open
Seventy years following the discovery of peroxisomes, their complete proteome, the peroxi-ome, remains undefined. Uncovering the peroxi-ome is crucial for understanding peroxisomal activities and cellular metabolism. We used high-content m…
View article: Comprehensive Dutch market data analysis shows that e-liquids with nicotine salts have both higher nicotine and flavour concentrations than those with free-base nicotine
Comprehensive Dutch market data analysis shows that e-liquids with nicotine salts have both higher nicotine and flavour concentrations than those with free-base nicotine Open
Objectives Recent years have seen an increase in e-liquids containing nicotine salts. Nicotine salts are less harsh and bitter than free-base nicotine and therefore can facilitate inhalation. Because inhalation-facilitating ingredients are…
View article: Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions
Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions Open
Seventy years following the discovery of peroxisomes, their proteome remains undefined. Uncovering the complete peroxisomal proteome, the peroxi-ome, is crucial for understanding peroxisomal activities and cellular metabolism. We used high…
View article: Conceptual model for the evaluation of attractiveness, addictiveness and toxicity of tobacco and related products: The example of JUUL e-cigarettes
Conceptual model for the evaluation of attractiveness, addictiveness and toxicity of tobacco and related products: The example of JUUL e-cigarettes Open
Many new tobacco and related products (nTRP) have emerged on the market, with unknown health risks. Here, we present a conceptual model containing the factors and relations between them that contribute to the nTRP's health effects. Factors…
View article: Improving the Analysis of E-Cigarette Emissions: Detecting Human “Dry Puff” Conditions in a Laboratory as Validated by a Panel of Experienced Vapers
Improving the Analysis of E-Cigarette Emissions: Detecting Human “Dry Puff” Conditions in a Laboratory as Validated by a Panel of Experienced Vapers Open
Introduction: E-cigarette product regulation requires accurate analyses of emissions. User behavior, including device power setting selection, should be mimicked closely when generating e-cigarette emissions in a laboratory. Excessively hi…
View article: Corrigendum: Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor
Corrigendum: Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor Open
[This corrects the article DOI: 10.3389/fcell.2020.00499.].
View article: Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor
Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor Open
X-linked adrenoleukodystrophy (ALD) is a devastating metabolic disorder affecting the adrenal glands, brain and spinal cord. Males with ALD are at high risk for developing adrenal insufficiency or progressive cerebral white matter lesions …
View article: Characteristic Human Individual Puffing Profiles Can Generate More TNCO than ISO and Health Canada Regimes on Smoking Machine When the Same Brand Is Smoked
Characteristic Human Individual Puffing Profiles Can Generate More TNCO than ISO and Health Canada Regimes on Smoking Machine When the Same Brand Is Smoked Open
Human smoking behavior influences exposure to smoke toxicants and is important for risk assessment. In a prospective observational study, the smoking behavior of Marlboro smokers was measured for 36 h. Puff volume, duration, frequency, flo…
View article: The Health Risks of Electronic Cigarette Use to Bystanders
The Health Risks of Electronic Cigarette Use to Bystanders Open
This works aimed to assess the health risks of e-cigarette use to bystanders. The exhaled breath of 17 volunteers was collected while they were vaping, and the levels of nicotine, propylene glycol, glycerol, formaldehyde, acetaldehyde, acr…
View article: The health risks of using e-cigarettes
The health risks of using e-cigarettes Open
Engelse vertaling van rapport 2014-0143: De gezondheidsrisico's van het gebruik van e-cigaretten
View article: Identification of flavour additives in tobacco products to develop a flavour library
Identification of flavour additives in tobacco products to develop a flavour library Open
Objectives This study combines chemical analysis and flavour descriptions of flavour additives used in tobacco products, and provides a starting point to build an extensive library of flavour components, useful for product surveillance. Me…
View article: The Sensory Difference Threshold of Menthol Odor in Flavored Tobacco Determined by Combining Sensory and Chemical Analysis
The Sensory Difference Threshold of Menthol Odor in Flavored Tobacco Determined by Combining Sensory and Chemical Analysis Open
Cigarettes are an often-used consumer product, and flavor is an important determinant of their product appeal. Cigarettes with strong nontobacco flavors are popular among young people, and may facilitate smoking initiation. Discriminating …
View article: Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma
Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma Open