Wouter Korver
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View article: Regulation of mast cells by overlapping but distinct protein interactions of Siglec‐6 and Siglec‐8
Regulation of mast cells by overlapping but distinct protein interactions of Siglec‐6 and Siglec‐8 Open
Background Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐6 and Siglec‐8 are closely related mast cell (MC) receptors with broad inhibitory activity, but whose functional differences are incompletely understood. Methods Proteomic …
View article: Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells
Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells Open
View article: 1396 Antibody blockade of the immunoinhibitory receptor Siglec 10 polarizes tumor associated myeloid cells and promotes anti-tumor immunity
1396 Antibody blockade of the immunoinhibitory receptor Siglec 10 polarizes tumor associated myeloid cells and promotes anti-tumor immunity Open
Background Myeloid cells are the most abundant immune cells within the tumor microenvironment (TME) where they play important roles regulating anti-tumor immunity. Targeting myeloid-specific inhibitory receptors to modulate the TME represe…
View article: Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells
Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells Open
Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed. …
View article: The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation
The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation Open
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity i…
View article: Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody
Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody Open
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-…
View article: A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation Open
In addition to their well characterized role in mediating IgE-dependent allergic diseases, aberrant accumulation and activation of mast cells (MCs) is associated with many non-allergic inflammatory diseases, whereby their activation is lik…
View article: A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys
A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys Open
Ectoenzyme CD38 is increased on lymphocytes in response to an antigenic challenge and it is hypothesized that targeting these activated lymphocytes could ameliorate pathologic activities in autoimmune diseases. The cynomolgus monkey is an …
View article: IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes
IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes Open