W. Richard Marsh
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View article: Implantation accuracy of novel polyimide stereotactic electroencephalographic depth electrodes—a human cadaveric study
Implantation accuracy of novel polyimide stereotactic electroencephalographic depth electrodes—a human cadaveric study Open
Introduction Stereoelectroencephalography (sEEG) is a minimally invasive procedure that uses depth electrodes stereotactically implanted into brain structures to map the origin and propagation of seizures in epileptic patients. Implantatio…
View article: Temporal encephalocele: An epileptogenic focus confirmed by direct intracranial electroencephalography
Temporal encephalocele: An epileptogenic focus confirmed by direct intracranial electroencephalography Open
Several studies have suggested the epileptogenic potential of temporal encephaloceles. However, there is limited literature describing the results of intracranial EEG monitoring for patients with temporal encephaloceles. We describe a 19 y…
View article: Outcomes of epilepsy surgery in the older population: not too old, not too late
Outcomes of epilepsy surgery in the older population: not too old, not too late Open
OBJECTIVE The prevalence of epilepsy in the older adult population is increasing. While surgical intervention in younger patients is supported by level I evidence, the safety and efficacy of epilepsy surgery in older individuals is less we…
View article: Outcomes following surgical management of vagus nerve stimulator–related infection: a retrospective multi-institutional study
Outcomes following surgical management of vagus nerve stimulator–related infection: a retrospective multi-institutional study Open
OBJECTIVE Surgical site infection (SSI) is a rare but significant complication after vagus nerve stimulator (VNS) placement. Treatment options range from antibiotic therapy alone to hardware removal. The optimal therapeutic strategy remain…
View article: Outcomes in single-level posterior cervical spine surgeries performed in the sitting and prone positions
Outcomes in single-level posterior cervical spine surgeries performed in the sitting and prone positions Open
OBJECTIVE The sitting or semisitting position in neurosurgery allows for several technical advantages, including improved visualization of the surgical field. However, it has also been associated with an increased risk of venous air emboli…
View article: Laser ablation for mesial temporal epilepsy: a multi-site, single institutional series
Laser ablation for mesial temporal epilepsy: a multi-site, single institutional series Open
OBJECTIVE Although it is still early in its application, laser interstitial thermal therapy (LiTT) has increasingly been employed as a surgical option for patients with mesial temporal lobe epilepsy. This study aimed to describe mesial tem…
View article: Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy
Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy Open
Summary Objective Evaluate the seizure‐reduction response and safety of mesial temporal lobe ( MTL ) brain‐responsive stimulation in adults with medically intractable partial‐onset seizures of mesial temporal lobe origin. Methods Subjects …
View article: Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas
Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas Open
Summary Objective Evaluate the seizure‐reduction response and safety of brain‐responsive stimulation in adults with medically intractable partial‐onset seizures of neocortical origin. Methods Patients with partial seizures of neocortical o…
View article: Reactivation of seizure‐related changes to interictal spike shape and synchrony during postseizure sleep in patients
Reactivation of seizure‐related changes to interictal spike shape and synchrony during postseizure sleep in patients Open
Summary Objective Local field potentials ( LFP s) arise from synchronous activation of millions of neurons, producing seemingly consistent waveform shapes and relative synchrony across electrodes. Interictal spikes ( IIS s) are LFP s assoc…
View article: Magnetic resonance imaging–guided laser interstitial thermal therapy for previously treated hypothalamic hamartomas
Magnetic resonance imaging–guided laser interstitial thermal therapy for previously treated hypothalamic hamartomas Open
OBJECTIVE Hypothalamic hamartomas (HHs) are associated with gelastic seizures and the development of medically refractory epilepsy. Magnetic resonance imaging–guided laser interstitial thermal therapy (MRg-LITT) is a minimally invasive abl…
View article: Outcomes following myxopapillary ependymoma resection: the importance of capsule integrity
Outcomes following myxopapillary ependymoma resection: the importance of capsule integrity Open
OBJECT While extent of resection has been shown to correlate with outcomes after myxopapillary ependymoma (MPE) resection, the effect of capsular violation has not been well studied. The role of adjuvant radiation also remains controversia…
View article: Testicular ptosis as a sign of L2 radiculopathy
Testicular ptosis as a sign of L2 radiculopathy Open
A 71-year-old man was referred to the Mayo Comprehensive Spine Center for possible surgery on a left L2–3 disk extrusion. Superimposed on a past history of episodic low back pain, 6 months prior, the patient developed major low back and le…
View article: Evidence for Consolidation of Neuronal Assemblies after Seizures in Humans
Evidence for Consolidation of Neuronal Assemblies after Seizures in Humans Open
The establishment of memories involves reactivation of waking neuronal activity patterns and strengthening of associated neural circuits during slow-wave sleep (SWS), a process known as “cellular consolidation” (Dudai and Morris, 2013). Re…
View article: Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone
Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone Open
The occurrence of locally generated gamma oscillations preceding IEDs suggests a mechanistic role for gamma in pathologic network activity generating IEDs. The results show a strong association between SOZ and gamma-IEDs. The potential cli…