Jiayan Wu
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View article: The adaptive growth and mechanisms of <i>Klebsiella pneumoniae</i> under sucrose and glucose exposure
The adaptive growth and mechanisms of <i>Klebsiella pneumoniae</i> under sucrose and glucose exposure Open
Klebsiella pneumoniae commonly colonizes the gastrointestinal (GI) mucosa of animals and healthy humans. Successful GI colonization by K. pneumoniae requires overcoming the colonization resistance (CR) exerted by the gut microbiota. Althou…
View article: Stage-dependent EZH2 methylation correlates with immune polarization, metabolic suppression, and unfavorable outcomes in hepatocellular carcinoma
Stage-dependent EZH2 methylation correlates with immune polarization, metabolic suppression, and unfavorable outcomes in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC), the most prevalent form of primary liver cancer, continues to pose significant clinical challenges globally. Enhancer of Zeste Homolog 2 (EZH2), a central component of the Polycomb Repressive Complex 2 (PRC2…
View article: High-capillarity limit and smoothing effect of large solutions for a multi-dimensional generic non-conservative compressible two-fluid model
High-capillarity limit and smoothing effect of large solutions for a multi-dimensional generic non-conservative compressible two-fluid model Open
We investigate the global existence and long-time behavior of large solutions, in the high-capillarity regime, for a general multidimensional non-conservative compressible two-fluid model with the capillary pressure relation \(f(α^{-}ρ^{-}…
View article: Gamma-tocopherol vitamin E enhances the cytotoxicity of p-cresyl sulfate to renal tubular cells
Gamma-tocopherol vitamin E enhances the cytotoxicity of p-cresyl sulfate to renal tubular cells Open
In this study, our results constitute the first demonstration that γ-tocopherol may cause renal-cell damage and enhance PCS-induced toxicity to renal cells via the apoptotic cell-death pathway.
View article: Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8+ T cells generating CD4+CD25+ regulatory T cells
Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8+ T cells generating CD4+CD25+ regulatory T cells Open
The roles of donor liver natural killer (NK) cells in allogeneic liver transplantation remains controversial. Herein, we investigated the effects of liver NK cells on liver allograft tolerance by using liver NK cells and allogeneic spleen …
View article: Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins
Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins Open
Klebsiella pneumoniae can be cultured in medium with xylose as the sole carbon source. However, the effect of xylose exposure on its growth adaptation, virulence, antimicrobial susceptibility, and proteomic response remain unclear. Here, w…
View article: Mechanism analysis of differential hypoxia tolerance ability among Penaeus vannamei families
Mechanism analysis of differential hypoxia tolerance ability among Penaeus vannamei families Open
This study investigated the mechanisms underlying the adaptation of different Penaeus vannamei families to hypoxia. We identified two hypoxia-tolerant families (HR A/B and HR C/D) and one hypoxia-sensitive family (FG I/J) for further stres…
View article: Nuclear‐Targeted Material Enabled Intranuclear MicroRNA Imaging for Tracking Gene Editing Process
Nuclear‐Targeted Material Enabled Intranuclear MicroRNA Imaging for Tracking Gene Editing Process Open
Gene editing technology based on clustered regularly interspaced short palindromic repeats/associated protein (CRISPR/Cas) systems serves as an efficient tool in cancer therapy. Tracking the gene editing process can help identify the progr…
View article: The non-conservative compressible two-fluid system with common pressure: Global existence and sharp time asymptotics
The non-conservative compressible two-fluid system with common pressure: Global existence and sharp time asymptotics Open
This paper concerns the global-in-time evolution of a generic compressible two-fluid model in $\mathbb{R}^d$ ($d\geq3$) with the common pressure law. Due to the non-dissipative properties for densities and two different particle paths caus…
View article: Primary tumor resection might improve outcomes in metastatic thoracic esophageal cancer
Primary tumor resection might improve outcomes in metastatic thoracic esophageal cancer Open
The study aims to evaluate the survival impact of primary tumor resection (PTR) on thoracic esophageal cancer with distant metastasis(TECDM). Data of patients with TECDM was collected from the Surveillance, Epidemiology, and End Results da…
View article: The clinical impact of galectin-8 in drug resistant breast cancer
The clinical impact of galectin-8 in drug resistant breast cancer Open
Breast cancer remains the leading cause of cancer-related mortality among women globally. A significant challenge in lowering breast cancer death rates is multidrug resistance. This resistance arises through various mechanisms, such as hei…
View article: Survival benefit of metastasectomy in colorectal cancer with pulmonary metastasis: a population-based, propensity score matched study
Survival benefit of metastasectomy in colorectal cancer with pulmonary metastasis: a population-based, propensity score matched study Open
Background The survival benefits of pulmonary metastasectomy (PM) in colorectal cancer (CRC) patients with pulmonary metastasis remain controversial. This study aimed to assess the survival effect of PM on CRC patients with pulmonary metas…
View article: Identification and validation of pyroptosis patterns with a novel quantification system for the prediction of prognosis in lung squamous cell carcinoma
Identification and validation of pyroptosis patterns with a novel quantification system for the prediction of prognosis in lung squamous cell carcinoma Open
The quantification of pyroptosis patterns was found to be important in predicting prognosis and devising personalized treatment strategies in patients with LUSC.
View article: Association of GhGeBP genes with fiber quality and early maturity related traits in upland cotton
Association of GhGeBP genes with fiber quality and early maturity related traits in upland cotton Open
Transcription Factors (TFs) are key regulators of how plants grow and develop. Among the diverse TF families, the Glabrous-enhancer binding protein (GeBP) family plays a key role in trichome initiation and leaf development. The specific ro…
View article: Improved Survival of Primary-Tumor Resection in Metastatic Thoracic Esophageal Cancer: A Population-Based, Propensity Score Matched Study
Improved Survival of Primary-Tumor Resection in Metastatic Thoracic Esophageal Cancer: A Population-Based, Propensity Score Matched Study Open
The study aims to assess the survival effect of primary-tumor resection (PTR) on thoracic esophageal cancer with distant metastasis(TECDM). Data of patients with TECDM was collected from the Surveillance, Epidemiology, and End Results data…
View article: Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8 + T cells and generating CD4 + CD25 + regulatory T cells
Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8 + T cells and generating CD4 + CD25 + regulatory T cells Open
The roles of donor liver natural killer (NK) cells in allogeneic liver transplantation remains controversial. Herein, we investigated the effects of liver NK cells on liver allograft tolerance by using liver NK cells and allogeneic spleen …
View article: Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review
Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review Open
Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as a dietary supplement, herbal remedy, and wellness product is steadily on the rise. Furthermore, the s…
View article: Whole genome doubling in adenomyosis
Whole genome doubling in adenomyosis Open
Whole genome doubling (WGD) was found to be associated with an early onset of the disease and a higher response rate to endocrine therapy among adenomyosis (AM) patients. The clinical manifestation could not be explained by commonly found …
View article: Cathepsins Influence Metastatic Liver Cancer via Plasma Proteins: a Mendelian randomization Study
Cathepsins Influence Metastatic Liver Cancer via Plasma Proteins: a Mendelian randomization Study Open
Background: Cathepsins (CTSs), lysosomal cysteine proteases, have been reported to play roles in the initiation, infiltration, and dissemination of tumors in previous researches. However, the precise causal relationship between CTSs and me…
View article: Regulation of TGF-β2-induced epithelial-mesenchymal transition and autophagy in lens epithelial cells by the miR-492/<i>NPM1</i> axis
Regulation of TGF-β2-induced epithelial-mesenchymal transition and autophagy in lens epithelial cells by the miR-492/<i>NPM1</i> axis Open
A cataract is a clinically common blinding disease closely related to the ageing of the eye cells, which has become a major health killer in the elderly. Our research seeks to analyze the primary targets linked to the pathogenesis of catar…
View article: The genomic and immune landscapes of gastric cancer and their correlations with <scp>HER2</scp> amplification and <scp>PD‐L1</scp> expression
The genomic and immune landscapes of gastric cancer and their correlations with <span>HER2</span> amplification and <span>PD‐L1</span> expression Open
Background Anti‐PD1/PD‐L1 antibody plus human epidermal growth factor receptor 2 (HER2) antibody and chemotherapy have become the new first‐line therapy for HER2 overexpression‐positive advanced gastric cancers (GC), suggesting that HER2 a…
View article: Semiconducting Polymer Nanospherical Nucleic Acid Probe for Transcriptomic Imaging of Cancer Chemo‐Immunotherapy
Semiconducting Polymer Nanospherical Nucleic Acid Probe for Transcriptomic Imaging of Cancer Chemo‐Immunotherapy Open
Real‐time in vivo imaging of RNA can enhance the understanding of physio‐pathological processes. However, most nucleic acid‐based sensors have poor resistance to nucleases and limited photophysical properties, making them suboptimal for th…
View article: EZH2-mediated epigenetic silencing of tumor- suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis
EZH2-mediated epigenetic silencing of tumor- suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis Open
Background Hepatitis B virus (HBV)-encoded X antigen, HBx, assists in the development of hepatocellular carcinoma (HCC) through complex mechanisms. Our results provide new insights into the EZH2 epigenetic repression of let-7c that promote…