Linrui Wu
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View article: Intentional Replantation Of A Mandibular Second Molar: A Case Report
Intentional Replantation Of A Mandibular Second Molar: A Case Report Open
Introduction: Intentional replantation is a viable option for preserving tooth when conventional nonsurgical endodontic retreatment and apical surgery have no effect. Case description: A 32-year-old female presented with chewing pain relat…
View article: A biosynthetic network for protoberberine production in <i>Coptis chinensis</i>
A biosynthetic network for protoberberine production in <i>Coptis chinensis</i> Open
Protoberberine alkaloids are a group of tetracyclic isoquinoline compounds known for their well-established antimicrobial and anti-inflammatory properties. The richness and diversity of protoberberine alkaloids accumulated in the Coptis ge…
View article: Regenerative Endodontic Procedures in Immature Permanent Teeth With Dental Trauma: Current Approaches and Challenges
Regenerative Endodontic Procedures in Immature Permanent Teeth With Dental Trauma: Current Approaches and Challenges Open
After dental trauma to immature permanent teeth (IPT), there can be pulpitis, necrotic, and periapical periodontitis, which will halt further root development. Traditional endodontic root canal treatments and apexification cannot revitaliz…
View article: Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid
Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid Open
View article: Two putative parallel pathways for naringenin biosynthesis in <i>Epimedium wushanense</i>
Two putative parallel pathways for naringenin biosynthesis in <i>Epimedium wushanense</i> Open
A set of enzymes from Epimedium wushanense, which showed activity for converting l-Phe and l-Tyr to pinocembrin and naringenin in parallel was characterized. The findings provide an evidence for a cryptic pathway converting pinocembrin to …
View article: Identification of 5-Fluoro-5-Deoxy-Ribulose as a Shunt Fluorometabolite in Streptomyces sp. MA37
Identification of 5-Fluoro-5-Deoxy-Ribulose as a Shunt Fluorometabolite in Streptomyces sp. MA37 Open
A fluorometabolite, 5-fluoro-5-deoxy-D-ribulose (5-FDRul), from the culture broth of the soil bacterium Streptomyces sp. MA37, was identified through a combination of genetic manipulation, chemo-enzymatic synthesis and NMR comparison. Alth…
View article: An unusual metal-bound 4-fluorothreonine transaldolase from Streptomyces sp. MA37 catalyses promiscuous transaldol reactions
An unusual metal-bound 4-fluorothreonine transaldolase from Streptomyces sp. MA37 catalyses promiscuous transaldol reactions Open
β-Hydroxy-α-amino acids (βH-AAs) are key components of many bioactive molecules as well as exist as specialised metabolites. Among these βH-AAs, 4-fluorothreonine (4-FT) is the only naturally occurring fluorinated AA discovered thus far. H…
View article: Signalling and Bioactive Metabolites from Streptomyces sp. RK44
Signalling and Bioactive Metabolites from Streptomyces sp. RK44 Open
Streptomyces remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of Streptomyces sp. RK44 …
View article: Defluorination of 4-fluorothreonine by threonine deaminase
Defluorination of 4-fluorothreonine by threonine deaminase Open
Threonine deaminase from E. coli catalyses defluorination on 4-fluorothreonine.