Zhenhua Wu
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View article: An efficient transient expression system for study of endosperm development in plants
An efficient transient expression system for study of endosperm development in plants Open
View article: Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages
Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages Open
View article: Morin alleviates sepsis-associated encephalopathy through inhibiting ferroptosis via SIRT1
Morin alleviates sepsis-associated encephalopathy through inhibiting ferroptosis via SIRT1 Open
Morin alleviates SAE by inhibiting ferroptosis via SIRT1.
View article: Persona-Aware Alignment Framework for Personalized Dialogue Generation
Persona-Aware Alignment Framework for Personalized Dialogue Generation Open
Personalized dialogue generation aims to leverage persona profiles and dialogue history to generate persona-relevant and consistent responses. Mainstream models typically rely on token-level language model training with persona dialogue da…
View article: Integrative machine learning and multi-omics framework identifies shared biomarkers for rheumatoid arthritis and ulcerative colitis
Integrative machine learning and multi-omics framework identifies shared biomarkers for rheumatoid arthritis and ulcerative colitis Open
Background Rheumatoid arthritis (RA) and ulcerative colitis (UC) are chronic inflammatory diseases with shared immune pathologies but limited common diagnostic biomarkers, which hinders the development of targeted therapies. Methods Public…
View article: Numerical Modeling of Photothermal Self‐Excited Composite Oscillators
Numerical Modeling of Photothermal Self‐Excited Composite Oscillators Open
Autonomous motion, such as self‐excited oscillation, emerges from the intricate interaction between structural deformation and external stimulation. By carefully engineering this interaction, diverse modes of locomotion have been achieved …
View article: Spatial pattern and its driving forces analysis of soil available nitrogen, phosphorus, and potassium in semi-arid grassland surface coal mining areas
Spatial pattern and its driving forces analysis of soil available nitrogen, phosphorus, and potassium in semi-arid grassland surface coal mining areas Open
Mining activities not only provide a large amount of material basis for socio-economic development but also cause great damage to the environment. It is of great significance to study the spatial variation characteristics of soil Available…
View article: Case Report: Effective treatment of dystrophic epidermolysis bullosa pruriginosa with tofacitinib
Case Report: Effective treatment of dystrophic epidermolysis bullosa pruriginosa with tofacitinib Open
Epidermolysis bullosa (EB) is a heterogeneous group of hereditary skin diseases caused by mutations in structural proteins at the dermal-epidermal junction. Dystrophic epidermolysis bullosa (DEB), one of its main types, is characterized by…
View article: Bilayer Biomimetic Scaffolds Loaded with Mesenchymal Stem Cell Secretomes Promote Diabetic Wound Healing
Bilayer Biomimetic Scaffolds Loaded with Mesenchymal Stem Cell Secretomes Promote Diabetic Wound Healing Open
Diabetic ulcers are among the most common and challenging complications of diabetes mellitus, and effective therapeutic strategies remain elusive. While stem cell secretome (SCS)-based therapy has attracted considerable attention due to it…
View article: Correlation of telomere length and DNA damage markers with severity and associated depressive states in patients with OSAS
Correlation of telomere length and DNA damage markers with severity and associated depressive states in patients with OSAS Open
Objective Investigation of the correlation of peripheral blood leukocyte relative telomere length (RTL) and DNA damage markers with severity and related depressive states in patients with obstructive sleep apnea syndrome (OSAS). Methods A …
View article: Targeting Macrophage Ferroptosis: A Mechanism of Lanxangia tsaoko methanol extract Inhibits VEGF to Attenuates ulcerative colitis
Targeting Macrophage Ferroptosis: A Mechanism of Lanxangia tsaoko methanol extract Inhibits VEGF to Attenuates ulcerative colitis Open
Background Lanxangia tsaoko is a kind of traditional Chinese medicine that is both food and medicine and has a long history in the treatment of gastrointestinal diseases. Recent studies have found that the methanol extract of Lanxangia tsa…
View article: Outraged AI: Large language models prioritise emotion over cost in fairness enforcement
Outraged AI: Large language models prioritise emotion over cost in fairness enforcement Open
Emotions guide human decisions, but whether large language models (LLMs) use emotion similarly remains unknown. We tested this using altruistic third-party punishment, where an observer incurs a personal cost to enforce fairness, a hallmar…
View article: Application of Building Information Modeling for Energy Efficiency: A Systematic Review
Application of Building Information Modeling for Energy Efficiency: A Systematic Review Open
As global warming worsens, reducing energy use is becoming increasingly crucial. In recent years, 34% of the world’s energy use has been consumed by buildings. Therefore, improving building energy efficiency is essential for halting climat…
View article: Effect of perioperative repetitive transcranial magnetic stimulation on postoperative cognitive function and peripheral inflammation in elderly total knee arthroplasty patients: study protocol for a randomized controlled trial
Effect of perioperative repetitive transcranial magnetic stimulation on postoperative cognitive function and peripheral inflammation in elderly total knee arthroplasty patients: study protocol for a randomized controlled trial Open
View article: C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling
C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling Open
Protein arginine methyltransferase 5 (PRMT5) complexes with methylosome protein 50 (MEP50) play crucial roles in tumor progress. However, the regulatory mechanism of governing the PRMT5-MEP50 hetero-octameric complex remains unclear. Here,…
View article: SwimmingIndividuals: A High-Performance Agent-Based Model for Marine Ecosystems
SwimmingIndividuals: A High-Performance Agent-Based Model for Marine Ecosystems Open
Mechanistic models are essential for projecting ecosystem responses to novel conditions, yet the application and biological realism of agent-based models (ABMs) has often been limited by computational constraints. This paper introduces Swi…
View article: Comparative efficacy of UBE simple decompression versus UBE-PLIF in treating degenerative lumbar spondylolisthesis secondary to spinal stenosis: A retrospective study
Comparative efficacy of UBE simple decompression versus UBE-PLIF in treating degenerative lumbar spondylolisthesis secondary to spinal stenosis: A retrospective study Open
The optimal surgical strategy for Meyerding grade I degenerative lumbar spondylolisthesis secondary to spinal stenosis remains controversial. We compared unilateral biportal endoscopic (UBE) simple decompression versus UBE-assisted posteri…
View article: Field polarity effects on single and dual-droplet transport and evaporation in electric fields
Field polarity effects on single and dual-droplet transport and evaporation in electric fields Open
View article: Importance of Life’s Essential 8 in predicting short- and long-term incidence of cardiovascular disease: The atherosclerosis risk in communities study
Importance of Life’s Essential 8 in predicting short- and long-term incidence of cardiovascular disease: The atherosclerosis risk in communities study Open
A higher LE8 score is consistently associated with a lower probability of the incidence of CHD during both short-term and long-term follow-up periods.
View article: Homogeneously cross-linked in situ hydrogel enclosing high-density human-cancer cells promotes vascularized in vivo tumor modeling for immune cell therapy
Homogeneously cross-linked in situ hydrogel enclosing high-density human-cancer cells promotes vascularized in vivo tumor modeling for immune cell therapy Open
Cancer models in animal studies play a central role in cancer research, particularly in investigating vascularized tumor tissues for the validation of immune cell therapies. However, xenografts relying solely on cancer cells are ineffectiv…
View article: Habitat subregions analysis based on neurite orientation dispersion and density imaging enhances isocitrate dehydrogenase genotyping in glioma
Habitat subregions analysis based on neurite orientation dispersion and density imaging enhances isocitrate dehydrogenase genotyping in glioma Open
Background Noninvasive isocitrate dehydrogenase (IDH) genotyping in gliomas remains a critical challenge. This study investigates the performance of the whole-tumor histogram analysis of neurite orientation dispersion and density imaging (…
View article: Comparative analysis of the efficacy of UBE-PLIF versus conventional PLIF in the treatment of L4-5 degenerative spondylolisthesis
Comparative analysis of the efficacy of UBE-PLIF versus conventional PLIF in the treatment of L4-5 degenerative spondylolisthesis Open
Background L4-5 lumbar degenerative spondylolisthesis is a common spinal disease in the middle-aged and elderly population, often accompanied by spinal stenosis and nerve root compression, which seriously affects the quality of life. Tradi…
View article: TrustJudge: Inconsistencies of LLM-as-a-Judge and How to Alleviate Them
TrustJudge: Inconsistencies of LLM-as-a-Judge and How to Alleviate Them Open
The adoption of Large Language Models (LLMs) as automated evaluators (LLM-as-a-judge) has revealed critical inconsistencies in current evaluation frameworks. We identify two fundamental types of inconsistencies: (1) Score-Comparison Incons…
View article: Noncontact Laser-Induced Ultrasound for Composites Inspection: Approaches for Material Discontinuity Visualization
Noncontact Laser-Induced Ultrasound for Composites Inspection: Approaches for Material Discontinuity Visualization Open
Pulsed laser techniques enable non-contact generation of ultrasound in composite materials and can provide full-wavefield data. Nonetheless, since a pulsed laser provides a broadband excitation of acoustic waves, the resulting field contai…
View article: Clinical Outcomes of <scp>RA FE</scp> ‐ <scp>TLIF</scp> Compared to <scp>FE</scp> ‐ <scp>TLIF</scp> in Patients With Lumbar Spondylolisthesis: A Retrospective Study
Clinical Outcomes of <span>RA FE</span> ‐ <span>TLIF</span> Compared to <span>FE</span> ‐ <span>TLIF</span> in Patients With Lumbar Spondylolisthesis: A Retrospective Study Open
Background Lumbar spondylolisthesis (LS) is a spinal disorder that often necessitates surgical intervention. However, evidence on the comparative clinical value of robot‐assisted full‐endoscopic transforaminal lumbar interbody fusion (RA F…
View article: Risk factor analysis and establishment of a predictive model for epilepsy comorbid with depression
Risk factor analysis and establishment of a predictive model for epilepsy comorbid with depression Open
Objective This study aims to utilize our hospital’s existing Stereo Electroencephalography (SEEG) examination results combined with other clinical data to systematically analyze the risk factors for epilepsy comorbid with depression, and t…
View article: Inhibition of LOXL2 Suppresses Nasal Mucosal Inflammation and Remodeling in Allergic Rhinitis
Inhibition of LOXL2 Suppresses Nasal Mucosal Inflammation and Remodeling in Allergic Rhinitis Open
Our proteomic analysis suggests that LOXL2 may be involved in the pathological remodeling processes of AR, potentially through modulation of the TGF-β1/Smad signaling pathway. These findings provide preliminary evidence that LOXL2 could se…
View article: Correction: The impact of altered gut microbiota and lipid metabolism on the progression of endometrial cancer in overweight populations
Correction: The impact of altered gut microbiota and lipid metabolism on the progression of endometrial cancer in overweight populations Open
[This corrects the article DOI: 10.3389/fendo.2025.1610534.].
View article: Prediction and Application of 0.2 m Resistivity Logging Curves Based on Extreme Gradient Boosting
Prediction and Application of 0.2 m Resistivity Logging Curves Based on Extreme Gradient Boosting Open
The G Block of Daqing Oilfield is a crucial area for sustainable development and stable production. In addressing the technical bottlenecks of high-resolution logging data interpretation for reservoir evaluation in the Block, this study pr…
View article: Impact of Multimorbidity on Quality of Life: The Mediation Role of Intrinsic Capacity – Evidence from the WHO ICOPE Pilot Program in Lianyungang of China
Impact of Multimorbidity on Quality of Life: The Mediation Role of Intrinsic Capacity – Evidence from the WHO ICOPE Pilot Program in Lianyungang of China Open
Introduction: Quality of life (QoL) is associated with multimorbidity, but the underlying mechanisms remain poorly understood. This study aimed to explore the association between multimorbidity and QoL, focusing on intrinsic capacity (IC) …