Wen‐Hsiung Li
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Author Swipe
Nitrogen-fixing microbes gain genes in diverse types of living environments Open
Biological nitrogen fixation (BNF), which is catalyzed by a large nitrogenase enzyme complex, has evolved in both bacteria and archaea. Indeed, nitrogen-fixing species are found in diverse living environments, and BNF has evolved even in a…
SARS-CoV-2 Evolution in Humans Enables Its Transmission to Nonhuman Primates Open
Zoonotic viruses frequently cross-species barriers, but the molecular processes enabling reverse zoonosis remain poorly defined. The COVID-19 pandemic provided an unprecedented opportunity to track SARS-CoV-2 evolution in humans and its ca…
Eco-genomic analysis uncovers precision-conservation targets for the western Pacific’s southernmost salmonid Open
Understanding how isolated small populations persist and adapt in adverse environments is instrumental to evolutionary and conservation biology. We combine a chromosome-level genome assembly, population resequencing and forward-time simula…
View article: A Machine Learning-Based Privacy-Preserving Medical Diagnostic System
A Machine Learning-Based Privacy-Preserving Medical Diagnostic System Open
In recent years, public awareness of healthcare has markedly improved, leading to a heightened demand for medical and health services. This trend is evident in the increased flow of outpatient visits, the rise in health check-ups, and the …
DGP-DETR : A real-time detection algorithm for underwater target detection Open
The exploration of contemporary underwater visual information collection faces issues of poor image fidelity and the complexity of heterogeneous backgrounds. To address these challenges, this paper proposes the DGP-DETR target detection ar…
View article: PUMA reduces FASN ubiquitination to promote lipid accumulation and tumor progression in human clear cell renal cell carcinoma
PUMA reduces FASN ubiquitination to promote lipid accumulation and tumor progression in human clear cell renal cell carcinoma Open
While the p53 upregulated modulator of apoptosis (PUMA) is traditionally recognized for promoting cell apoptosis and enhancing chemotherapy efficacy in various cancers, its role in clear cell renal cell carcinoma (ccRCC) remains unclear du…
Exploration of ascomycetous fungi revealing novel taxa in Southwestern China Open
This study explores the fungal diversity of Southwestern China, focusing on ascomycetous fungi associated with decaying plant materials. Through morphological and multi-locus phylogenetic analyses, we identified 31 new species and a new ge…
Genetic analysis of a female patient with X-linked lymphoproliferative disease type 2: a case report Open
Close attention should be paid to shifts in X-chromosome inactivation in female children. When a pathogenic gene variant is not detected in a mother with a normal phenotype, gonadal mosaicism cannot be ruled out, and prenatal genetic diagn…
Philosophical Reflections on Chinese Naturopathy against Malignant Tumours Open
How to recognize the pathogenesis of cancer and how to treat cancer? This involves the "epistemology" and "methodology" of medical philosophy. With the arrival of the global aging society, and after the Covid-19 Pandemic, cancer has become…
Prenatal diagnosis of intellectual disability, autosomal dominant 29 with a nonsense pathogenic variant in SETBP1: a case report and literature review Open
Introduction Intellectual disability, autosomal dominant 29 is a rare disorder resulting from pathogenic variants of SETBP1 gene with no specific mutation hotspot identified. Systematic descriptions of new cases are crucial for understandi…
Case Report: Area of focus clinical presentation and KMT2D gene mutation at the c.15535C>T site in a case of Kabuki syndrome Open
Background Kabuki syndrome (KS) is a rare autosomal dominant genetic disorder. The full understanding of KS remains elusive due to the heterogeneity of gene mutations, clinical phenotypes, and the associations and mechanisms linking genoty…
View article: Reducing cardiometabolic disease risk dietary pattern in the Chinese population with dyslipidemia: a single-center, open-label, randomized, dietary intervention study
Reducing cardiometabolic disease risk dietary pattern in the Chinese population with dyslipidemia: a single-center, open-label, randomized, dietary intervention study Open
This trial was registered at Chinese Clinical Trial Registry as ChiCTR2300072472 (https://www.chictr.org.cn/showproj.html?proj=198618).
Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses Open
Introduction COVID-19 severity has been linked to immune factors, with excessive immune responses like cytokine storms contributing to mortality. However, the genetic basis of these immune responses is not well understood. This study aimed…
View article: Impact of the thin-walled sheath on the distal radial artery occlusion: a randomized trial
Impact of the thin-walled sheath on the distal radial artery occlusion: a randomized trial Open
Background Distal transradial access (dTRA) has been increasingly accepted as an alternative to the transradial access (TRA) for coronary angiography (CAG) and/or percutaneous coronary intervention (PCI). Although the dTRA has been signifi…
The fear of cancer recurrence in elderly patients after endoscopic submucosal dissection for early esophageal cancer: a cross-sectional study Open
The FCR is high in elderly patients after ESD for early esophageal cancer. Healthcare professionals should implement personalized disease-related health education programs to help patients reduce their fear of the disease, guide patients t…
Real-time monitoring of nanocellulose suspension concentration using a liquid–solid triboelectric nanogenerator Open
Monitoring and controlling the concentration of nanocellulose suspensions is crucial for various industrial processes. Because of the high complexity of traditional concentration measurement devices, new techniques that offer simple, relia…
IFITM10 Enhance Tumor Angiogenesis and Promotes Cancer Progression through STAT3 Activation Open
Background: Humankind have been struggling with colorectal cancer (CRC) for long period with its rapid progression and invasive metastasis. By hyperactivating IL-6/STAT3 signaling, CRC facilitates the capacity of angiogenesis to plunder ma…
Fetal membrane imaging: current and future perspectives—a review Open
Fetal membrane providing mechanical support and immune protection for the growing fetus until it ruptures during parturition. The abnormalities of fetal membrane (thickening, separation, etc.) are related to adverse perinatal outcomes such…
Data from Identification of a Tumor-Suppressive Human-Specific MicroRNA within the <i>FHIT</i> Tumor-Suppressor Gene Open
Loss or attenuated expression of the tumor-suppressor gene FHIT is associated paradoxically with poor progression of human tumors. Fhit promotes apoptosis and regulates reactive oxygen species; however, the mechanism by which Fhit inhibits…
Data from Identification of a Tumor-Suppressive Human-Specific MicroRNA within the <i>FHIT</i> Tumor-Suppressor Gene Open
Loss or attenuated expression of the tumor-suppressor gene FHIT is associated paradoxically with poor progression of human tumors. Fhit promotes apoptosis and regulates reactive oxygen species; however, the mechanism by which Fhit inhibits…
川西北深层中二叠统茅口组岩相古地理及勘探意义 Open
摘要: 四川盆地西北部是深层油气勘探的重点区域,围绕"开江-梁平海槽"发现多个长兴组台缘礁滩型气田. 近年,随着该油气带下的茅口组获得新的油气发现,海槽的形成时间和范围及其对茅口组有利勘探区带的约束成为新的研究热点.基于川西北地区剖面钻井资料,详细开展茅口组的岩相古地理重建. 揭示出川西北地区茅口中-晚期呈现深水相和台地相的分异,相带沉积作用造成地层厚度的带状协同差异;重建了茅口中-晚期的岩相古地理,刻画出该时期的构造-沉积分异格局;明确"开江-梁平海槽"形成时间应向前推至…
Adventures of a Mathematician in Evolutionary Biology Open
Foreword In an occasional series of articles, we will be publishing autobiographical sketches from some of those working in the field of genome evolution. The series will feature both the very eminent, but also researchers closer to their …
Additional file 5 of The spatial distribution of cis regulatory elements in yeast promoters and its implications for transcriptional regulation Open
Additional file 5: A complete list of genes used in this study. This table includes the lists of genes of each group of TATA box-containing, TATA box-less, Type I-Type IV and the data of 5'UTR length, transcriptional level (log2) and gene …