Wuwei Ren
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Author Swipe
View article: A Warm-basis Method for Bridging Learning and Iteration: a Case Study in Fluorescence Molecular Tomography
A Warm-basis Method for Bridging Learning and Iteration: a Case Study in Fluorescence Molecular Tomography Open
Fluorescence Molecular Tomography (FMT) is a widely used non-invasive optical imaging technology in biomedical research. It usually faces significant accuracy challenges in depth reconstruction, and conventional iterative methods struggle …
View article: Robust residual-guided iterative reconstruction for sparse-view CT in small animal imaging
Robust residual-guided iterative reconstruction for sparse-view CT in small animal imaging Open
Objective . We introduce a robust image reconstruction algorithm named residual-guided Golub–Kahan iterative reconstruction technique (RGIRT) designed for sparse-view computed tomography (CT), which aims at high-fidelity image reconstructi…
View article: Simultaneous reconstruction of 3D fluorescence distribution and object surface using structured light illumination and dual-camera detection
Simultaneous reconstruction of 3D fluorescence distribution and object surface using structured light illumination and dual-camera detection Open
Fluorescence molecular tomography (FMT) serves as a noninvasive modality for visualizing volumetric fluorescence distribution within biological tissues, thereby proving to be an invaluable imaging tool for preclinical animal studies. The c…
View article: Multifunctional Optical Tomography System With High-Fidelity Surface Extraction Based on a Single Programmable Scanner and Unified Pinhole Modeling
Multifunctional Optical Tomography System With High-Fidelity Surface Extraction Based on a Single Programmable Scanner and Unified Pinhole Modeling Open
Our work explores the feasibility of obtaining additional surface information using existing components of standalone optical tomography. This makes the optical tomographic technique more accurate and more accessible to biomedical research…
View article: Augmented Flexible Krylov Subspace methods with applications to Bayesian inverse problems
Augmented Flexible Krylov Subspace methods with applications to Bayesian inverse problems Open
This paper presents two new augmented flexible (AF)-Krylov subspace methods, AF-GMRES and AF-LSQR, to compute solutions of large-scale linear discrete ill-posed problems that can be modeled as the sum of two independent random variables, e…
View article: Single-pixel p-graded-n junction spectrometers
Single-pixel p-graded-n junction spectrometers Open
Ultra-compact spectrometers are becoming increasingly popular for their promising applications in biomedical analysis, environmental monitoring, and food safety. In this work, we report a novel single-pixel-photodetector spectrometer with …
View article: Stochastic reconstruction of dual components facilitates high-fidelity in vivo fluorescence tomographic imaging
Stochastic reconstruction of dual components facilitates high-fidelity in vivo fluorescence tomographic imaging Open
Wide-field fluorescence imaging is an indispensable tool for longitudinal animal studies. However, light scattering in tissue imposes a fundamental challenge for accurately localizing and quantifying fluorophore distribution in depth. Conv…
View article: Stochastic reconstruction of dual components facilitates high-fidelity in vivo fluorescence tomographic imaging
Stochastic reconstruction of dual components facilitates high-fidelity in vivo fluorescence tomographic imaging Open
Wide-field fluorescence imaging is an indispensable tool for longitudinal animal studies. However, light scattering in tissue imposes a fundamental challenge for accurately localizing and quantifying fluorophore distribution in depth. Conv…
View article: High-resolution tomographic reconstruction of optical absorbance through scattering media using neural fields
High-resolution tomographic reconstruction of optical absorbance through scattering media using neural fields Open
Light scattering imposes a major obstacle for imaging objects seated deeply in turbid media, such as biological tissues and foggy air. Diffuse optical tomography (DOT) tackles scattering by volumetrically recovering the optical absorbance …
View article: Fast, accurate and robust sparse-view CT reconstruction via residual-guided Golub-Kahan iterative reconstruction technique (RGIRT)
Fast, accurate and robust sparse-view CT reconstruction via residual-guided Golub-Kahan iterative reconstruction technique (RGIRT) Open
Reduction of projection views in X-ray computed tomography (CT) can protect patients from over exposure to ionizing radiation, thus is highly attractive for clinical applications. However, image reconstruction for sparse-view CT which aims…
View article: Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography
Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography Open
Progress in brain research critically depends on the development of next-generation multi-modal imaging tools capable of capturing transient functional events and multiplexed contrasts noninvasively and concurrently, thus enabling a holist…
View article: Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography
Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography Open
Progress in brain research critically depends on the development of next-generation multi-modal imaging tools that are capable of capturing transient functional events and multiplexed contrasts noninvasively and concurrently. A number of o…
View article: A Novel Three-way fusion image segmentation for early esophageal cancer detection
A Novel Three-way fusion image segmentation for early esophageal cancer detection Open
Objective Esophageal cancer (EC) is a prevalent malignancy worldwide. Early-stage esophageal cancer (EEC) diagnostics is crucial for improving patient survival. However, EC is highly aggressive with a poor prognosis, even for experienced e…
View article: Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging
Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging Open
Multispectral optoacoustic tomography (MSOT) is an emerging optical imaging method providing multiplex molecular and functional information from the rodent brain. It can be greatly augmented by magnetic resonance imaging (MRI) which offers…
View article: Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography
Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography Open
Abnormal cerebral accumulation of amyloid-beta peptide (Aβ) is a major hallmark of Alzheimer’s disease. Non-invasive monitoring of Aβ deposits enables assessing the disease burden in patients and animal models mimicking aspects of the huma…
View article: Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics
Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics Open
Small animal models play a fundamental role in brain research by deepening the understanding of the physiological functions and mechanisms underlying brain disorders and are thus essential in the development of therapeutic and diagnostic i…
View article: Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography
Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography Open
Abnormal cerebral accumulation of amyloid-beta peptide (Aβ) is a major hallmark of Alzheimer’s disease. Non-invasive monitoring of Aβ deposits enables assessing the disease burden in patients and animal models mimicking aspects of the huma…
View article: PET Imaging of Neuroinflammation in Alzheimer’s Disease
PET Imaging of Neuroinflammation in Alzheimer’s Disease Open
Neuroinflammation play an important role in Alzheimer’s disease pathogenesis. Advances in molecular imaging using positron emission tomography have provided insights into the time course of neuroinflammation and its relation with Alzheimer…
View article: Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging
Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging Open
Multi-spectral optoacoustic tomography (MSOT) is an emerging optical imaging method providing multiplex molecular and functional information from the rodent brain. It can be greatly augmented by magnetic resonance imaging (MRI) that offers…
View article: Noninvasive multimodal fluorescence and magnetic resonance imaging of whole-organ intervertebral discs
Noninvasive multimodal fluorescence and magnetic resonance imaging of whole-organ intervertebral discs Open
Low back pain (LBP) is a commonly experienced symptom posing a tremendous healthcare burden to individuals and society at large. The LBP pathology is strongly linked to degeneration of the intervertebral disc (IVD), calling for development…
View article: Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography
Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography Open
Fluorescence molecular tomography (FMT) emerges as a powerful non-invasive imaging tool with the ability to resolve fluorescence signals from sources located deep in living tissues. Yet, the accuracy of FMT reconstruction depends on the de…
View article: Robust reconstruction of fluorescence molecular tomography with an optimized illumination pattern
Robust reconstruction of fluorescence molecular tomography with an optimized illumination pattern Open
Fluorescence molecular tomography (FMT) is an emerging powerful tool for biomedical research. There are two factors that influence FMT reconstruction most effectively. The first one is the regularization techniques. Traditional methods suc…
View article: Smart Toolkit for Fluorescence Tomography: Simulation, Reconstruction, and Validation
Smart Toolkit for Fluorescence Tomography: Simulation, Reconstruction, and Validation Open
This paper facilitates FMT experiments by bridging the gaps between simulation, actual experiments, and data reconstruction.
View article: Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies
Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies Open
Multimodal imaging combining optoacoustic tomography (OAT) with magnetic resonance imaging (MRI) enables spatiotemporal resolution complementarity, improves accurate quantification, and thus yields more insights into physiology and pathoph…
View article: Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography
Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography Open
Oxygen metabolism and matrix metalloproteinases (MMPs) play important roles in the pathophysiology of cerebral ischemia. Using multispectral optoacoustic tomography (MSOT) imaging, we visualized in vivo changes in cerebral tissue oxygenati…
View article: Non-invasive detection of matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral optoacoustic tomography
Non-invasive detection of matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral optoacoustic tomography Open
Matrix metalloproteinases (MMPs) play important roles in the pathophysiology of cerebral ischemia. Here we visualized in vivo MMP activity in the transient middle cerebral artery occlusion (tMCAO) mouse model using multispectral optoacoust…