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View article: Facilitating critical appraisal of evidence using automation tools
Facilitating critical appraisal of evidence using automation tools Open
The European Food Safety Authority (EFSA) initiated the “Roadmap for actions on Artificial Intelligence for evidence management in risk assessment” project in May 2021, aiming to optimize risk assessment processes by integrating Artificial…
View article: A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study
A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study Open
View article: Implementing AI Vertical use cases ‐ Scenario 1
Implementing AI Vertical use cases ‐ Scenario 1 Open
This report presents the activities and outcomes related to the five use cases (UCs) identified by EFSA within the Specific Contract No 1 implementing the Framework contract No OC/EFSA/AMU/2021/03. UC1 aims to assess the usability and effe…
View article: Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens
Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens Open
Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applie…
View article: Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study
Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study Open
Objectives: Pulmonary hypertension is one of the leading causes of death in systemic sclerosis. Early detection and treatment of pulmonary hypertension in systemic sclerosis is crucial. Nailfold capillaroscopy microscopy, vascular autoanti…
View article: Differential Pneumococcal Growth Features in Severe Invasive Disease Manifestations
Differential Pneumococcal Growth Features in Severe Invasive Disease Manifestations Open
Streptococcus pneumoniae is a leading infectious cause of deaths worldwide. To understand the course and outcome of pneumococcal infection, most research has focused on the host and its response to contain bacterial growth.
View article: Maternal pre-pregnancy overweight and neonatal gut bacterial colonization are associated with cognitive development and gut microbiota composition in pre-school-age offspring
Maternal pre-pregnancy overweight and neonatal gut bacterial colonization are associated with cognitive development and gut microbiota composition in pre-school-age offspring Open
Contains fulltext : 247189.pdf (Publisher’s version ) (Open Access)
View article: Charting host-microbe co-metabolism in skin aging and application to metagenomics data
Charting host-microbe co-metabolism in skin aging and application to metagenomics data Open
During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alteratio…
View article: Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients
Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients Open
Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment bu…
View article: High throughput screening of technological and biopreservation traits of a large set of wild lactic acid bacteria from Brazilian artisanal cheeses
High throughput screening of technological and biopreservation traits of a large set of wild lactic acid bacteria from Brazilian artisanal cheeses Open
View article: Training in Collecting, Appraising and Synthesising Evidence for EFSA scientific assessments
Training in Collecting, Appraising and Synthesising Evidence for EFSA scientific assessments Open
The overall objective of project OC/EFSA/AMU/2018/01 was to support EFSA to develop in-house capacity to collect, appraise and synthesize evidence coming from literature sources in the context of food and feed scientific assessment. This o…
View article: Autoantibody profiles in systemic sclerosis; a comparison of diagnostic tests
Autoantibody profiles in systemic sclerosis; a comparison of diagnostic tests Open
Our data showed high concordance of prevalent SSc-specific autoantibodies between different diagnostic assays. Further standardisation for low prevalent SSc-specific and SSc-associated autoantibodies is needed.
View article: Charting host-microbe co-metabolism in skin aging and application to metagenomics data
Charting host-microbe co-metabolism in skin aging and application to metagenomics data Open
During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alteratio…
View article: Het recept voor een succesvol data science project
Het recept voor een succesvol data science project Open
In de agro-chemie industrie wordt tegenwoordig een grote hoeveelheid data gegenereerd. De inzet van sensoren voor het monitoren van productieprocessen, het sequensen van gewassen en het karakteriseren van bodemmonsters zijn voorbeelden van…
View article: Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer’s disease
Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer’s disease Open
Delirium is a complex and multifactorial condition associated with long-term cognitive decline. Due to the strong links between systemic inflammation, delirium and dementia we hypothesized that responses within the brain in patients who de…
View article: Live Biotherapeutic Products, A Road Map for Safety Assessment
Live Biotherapeutic Products, A Road Map for Safety Assessment Open
Recent developments in the understanding of the relationship between the microbiota and its host have provided evidence regarding the therapeutic potential of selected microorganisms to prevent or treat disease. According to Directive 2001…
View article: Diagnostic profiles for precision medicine in systemic sclerosis; stepping forward from single biomarkers towards pathophysiological panels
Diagnostic profiles for precision medicine in systemic sclerosis; stepping forward from single biomarkers towards pathophysiological panels Open
Systemic sclerosis (SSc) is an autoimmune disease which is characterized by vasculopathy, tissue fibrosis and activation of the innate and adaptive immune system. Clinical features of the disease consists of skin thickening and internal or…
View article: Table of Contents
Table of Contents Open
View article: Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data – A systematic review protocol
Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data – A systematic review protocol Open
Nitrous oxide (N 2 O) is widely used as inhalation analgesic and anaesthetic in medical, paramedical, and veterinary practice. Previous evaluations resulted in classification of N 2 O as a possible risk factor for adv…
View article: Biosynthetic homeostasis and resilience of the complement system in health and infectious disease
Biosynthetic homeostasis and resilience of the complement system in health and infectious disease Open
View article: Training courses in systematic reviews or in specific steps of systematic review for EFSA Risk Assessment
Training courses in systematic reviews or in specific steps of systematic review for EFSA Risk Assessment Open
The overall objective of project OC/EFSA/AMU/2015/04 was to support EFSA to develop in-house capacity to perform systematic reviews in food and feed safety and extensive literature searches to inform systematic reviews. This objective had …
View article: Magnesium deficiency prevents high-fat-diet-induced obesity in mice
Magnesium deficiency prevents high-fat-diet-induced obesity in mice Open
View article: FRI0437 Is extended auto antibody profiling associated with the prevalence of disease complications?
FRI0437 Is extended auto antibody profiling associated with the prevalence of disease complications? Open
View article: Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis
Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis Open
Recently, we demonstrated that fermentation conditions have a strong impact on subsequent survival of Lactococcus lactis strain MG1363 during heat and oxidative stress, two important parameters during spray drying. Moreover, employment of …
View article: Draft Genome Sequence of Lactobacillus delbrueckii subsp <i>. bulgaricus</i> LBB.B5
Draft Genome Sequence of Lactobacillus delbrueckii subsp <i>. bulgaricus</i> LBB.B5 Open
Lactobacillus delbrueckii subsp . bulgaricus LBB.B5 originates from homemade Bulgarian yogurt and was selected for its ability to form a strong association with Streptococcus thermophilus . The genome sequence will facilitate elucidating t…
View article: Microbial bioinformatics for food safety and production
Microbial bioinformatics for food safety and production Open
In the production of fermented foods, microbes play an important role. Optimization of fermentation processes or starter culture production traditionally was a trial-and-error approach inspired by expert knowledge of the fermentation proce…
View article: Homer3 regulates the establishment of neutrophil polarity
Homer3 regulates the establishment of neutrophil polarity Open
Most chemoattractants rely on activation of the heterotrimeric G-protein Gαi to regulate directional cell migration, but few links from Gαi to chemotactic effectors are known. Through affinity chromatography using primary neutrophil lysate…