Chang Zhang
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View article: Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment
Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment Open
Human obesity is the fifth leading cause of global mortality. Fat mass loss and maintenance are central challenges for obesity management. In contrast, birds exhibit modest weight gain and limited fat accumulation due to rapid fat utilizat…
View article: Sleep matters: the U-shaped relationship between sleep duration and overactive bladder in U.S. adults
Sleep matters: the U-shaped relationship between sleep duration and overactive bladder in U.S. adults Open
Objectives To investigate the independent and combined associations of sleep duration and sleep disorders with the risk of overactive bladder (OAB) and identify threshold effects of sleep duration on OAB. Methods Data from the NHANES (2005…
View article: Dietary cholecalciferol and 25-hydroxyvitamin D3 supplementation improved eggshell and bone quality of laying ducks during 60 to 76 weeks of age
Dietary cholecalciferol and 25-hydroxyvitamin D3 supplementation improved eggshell and bone quality of laying ducks during 60 to 76 weeks of age Open
This study aimed to evaluate the effects of cholecalciferol (vitamin D3, VD3) or 25-hydroxyvitamin D3 (25(OH)D3) supplementation in the diet of aged laying ducks on eggshell and bone quality. A total of 792 healthy Longyan laying ducks (60…
View article: The impact of quadriceps release therapy on rehabilitation of adolescent athletes with Osgood-Schlatter disease: a retrospective cohort study
The impact of quadriceps release therapy on rehabilitation of adolescent athletes with Osgood-Schlatter disease: a retrospective cohort study Open
Objective Aimed at evaluating the impact of quadriceps muscle relaxation in the treatment of Osgood-Schlatter disease and analyzing the association between quadriceps tension and Osgood-Schlatter disease pathogenesis. Methods A retrospecti…
View article: Mechanistic insights into PDZK1-interacting protein 1 on the malignant progression of colorectal carcinoma
Mechanistic insights into PDZK1-interacting protein 1 on the malignant progression of colorectal carcinoma Open
Objective: PDZ domain containing 1-interacting protein 1 (PDZK1IP1) is commonly overexpressed in a wide variety of cancer. Hence, the objective of the present study is to ascertain the influences of PDZK1IP1 on colorectal carcinoma (CRC) d…
View article: Study on the Correlation Between Double‐Stranded <scp>DNA</scp> and Systemic Lupus Erythematosus
Study on the Correlation Between Double‐Stranded <span>DNA</span> and Systemic Lupus Erythematosus Open
Circulating cell‐free DNA (cfDNA) is a large molecule that plays a central role in the pathogenesis of SLE. It is the target antigen of autoantibodies and the main component of immune complexes. Due to the large differences in the content …
View article: The interaction between autophagy-related gene FtATG8a and FtE2FB is involved in the drought resistance of Tartary buckwheat
The interaction between autophagy-related gene FtATG8a and FtE2FB is involved in the drought resistance of Tartary buckwheat Open
Drought significantly limits worldwide crop yields, with autophagy acting as an essential regulatory component in plant adaptation to stress. In Tartary buckwheat, while there has been evidence of autophagosome accumulation and increased l…
View article: Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice Open
Reactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is signi…
View article: Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8 <sup>+</sup> T cells by granzyme B and perforin
Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8 <sup>+</sup> T cells by granzyme B and perforin Open
ST8Sia1 is a potential diagnostic biomarker and therapeutic target for READ, enhancing CD8+ T cell function and possibly improving patient outcomes through cellular immunotherapy.
View article: Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks
Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks Open
The ovary is the main controller of female fertility, unfortunately, its onset of aging processes was earlier than other organs. Our previous studies showed calcium (Ca) deficiency reduced ovarian weight and declined numbers of dominant fo…
View article: Early addition of enzyme-treated soybean in the diet improves amino acid absorption and protein digestibility by promoting digestive enzyme activity in broilers
Early addition of enzyme-treated soybean in the diet improves amino acid absorption and protein digestibility by promoting digestive enzyme activity in broilers Open
Early nutritional regulation has become a research hotspot. The present study was undertaken to assess dietary early addition enzyme-treated soybean meal (ESBM) on nutrient digestibility, amino acid absorption, and intestinal development o…
View article: A multicenter bladder cancer MRI dataset and baseline evaluation of federated learning in clinical application
A multicenter bladder cancer MRI dataset and baseline evaluation of federated learning in clinical application Open
Bladder cancer (BCa), as the most common malignant tumor of the urinary system, has received significant attention in research on the clinical application of artificial intelligence algorithms. Nevertheless, it has been observed that certa…
View article: Dietary supplementation with 25-hydroxyvitamin D3 regulates productive performance, lipid metabolism and gut microbiota in aged laying ducks
Dietary supplementation with 25-hydroxyvitamin D3 regulates productive performance, lipid metabolism and gut microbiota in aged laying ducks Open
The aim of this study was to investigate the effect of dietary supplementation with 25-hydroxyvitamin D3 (25(OH)D3) on productive performance, lipid metabolism and gut microbiota in aged laying ducks. A total of 432 healthy Longyan ducks a…
View article: Diagnostic and screening potential of plasma exosome miR‑99b‑5p and its combination with other miRNAs for colorectal cancer
Diagnostic and screening potential of plasma exosome miR‑99b‑5p and its combination with other miRNAs for colorectal cancer Open
Extracellular vesicles (EVs) secreted by tumor cells have been documented to hold viable biomarker potential. Therefore, the present study evaluated the potential clinical value of EV-microRNAs (miRNAs or miRs) in the plasma exosomes of pa…
View article: Sex hormones in COVID‐19 severity: The quest for evidence and influence mechanisms
Sex hormones in COVID‐19 severity: The quest for evidence and influence mechanisms Open
Studies have reported variable effects of sex hormones on serious diseases. Severe disease and mortality rates in COVID‐19 show marked gender differences that may be related to sex hormones. Sex hormones regulate the expression of the vira…
View article: Exposure to heavy metal elements may significantly increase serum prostate-specific antigen levels with overdosed dietary zinc
Exposure to heavy metal elements may significantly increase serum prostate-specific antigen levels with overdosed dietary zinc Open
With high-level zinc intake, serum PSA levels may rise in PCa-free men as the exposure to cadmium increases, leading to a potential risk of an overdiagnosis of PCa and unnecessary treatment. Therefore, environmental variables should be fac…
View article: High expression of malic enzyme 1 predicts adverse prognosis in patients with cytogenetically normal acute myeloid leukaemia and promotes leukaemogenesis through the IL-6/JAK2/STAT3 pathways
High expression of malic enzyme 1 predicts adverse prognosis in patients with cytogenetically normal acute myeloid leukaemia and promotes leukaemogenesis through the IL-6/JAK2/STAT3 pathways Open
Background: Progress in improving risk stratification methods for patients with cytogenetically normal acute myeloid leukaemia (CN-AML) remains limited. This study investigates the prognostic significance and potential functional mechanism…
View article: Anti-IL-22 neutralizing antibodies decrease inflammation lesions and reduce mortality in enterovirus 71-infected mice
Anti-IL-22 neutralizing antibodies decrease inflammation lesions and reduce mortality in enterovirus 71-infected mice Open
Hand, foot, and mouth disease (HFMD) can cause fatal encephalitis in 0-5-year-old infants and children. There is no effective antiviral drug available to treat HFMD caused by enterovirus 71 (EV71). Our study investigates the relationship b…