Cheng Yang
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View article: Genetic evidence of association between family factors and the risk of stroke: A 2-sample Mendelian randomization analysis
Genetic evidence of association between family factors and the risk of stroke: A 2-sample Mendelian randomization analysis Open
Family factors are often related to health and mental well-being. We aimed to investigate the causal relationship between family factors and the risk of stroke using Mendelian randomization (MR). The genome-wide association study data used…
View article: Joint association of nutritional and inflammatory status, and sedentary behavior on mortality in US adult cancer survivors: a population-based cohort study
Joint association of nutritional and inflammatory status, and sedentary behavior on mortality in US adult cancer survivors: a population-based cohort study Open
Our findings demonstrate that nutritional and inflammatory status and sedentary behavior collectively influence mortality risk in cancer survivors. Patients exhibiting concurrent poor nutrition, systemic inflammation (high NPS), and sedent…
View article: Extensive diversity of unusual microorganisms associated with severe pneumonia in kidney transplant recipients
Extensive diversity of unusual microorganisms associated with severe pneumonia in kidney transplant recipients Open
Although pneumonia is a common lung disease with a high morbidity and mortality, aside from well-known pathogens little is known about why, which and how many microorganisms are associated with the disease, particularly in immunocompromise…
View article: Intratracheal instillation of chitosan-coated formononetin-loaded porous microspheres prolongs lung retention and improves the treatment in bleomycin-induced pulmonary fibrosis
Intratracheal instillation of chitosan-coated formononetin-loaded porous microspheres prolongs lung retention and improves the treatment in bleomycin-induced pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung lesion, which is called a "tumor-like disease". Previous studies have confirmed that intratracheal instillation of formononetin-loaded porous microsp…
View article: Predictive value of urinary [TIMP-2]•[IGFBP7] for AKI among sepsis, stroke, and cardiac surgery cohorts: A prospective study
Predictive value of urinary [TIMP-2]•[IGFBP7] for AKI among sepsis, stroke, and cardiac surgery cohorts: A prospective study Open
Background: TIMP-2 and IGFBP7 have shown effectiveness as biomarkers for predicting Acute Kidney Injury (AKI). However, the variations in the predictive capacity of urinary [TIMP-2]• [IGFBP7] for AKI across different etiologies remain unex…
View article: Heterogeneity of Innate Immunity
Heterogeneity of Innate Immunity Open
Innate immune cells are essential components of the body's defense system; they are capable of developing immune memory and differentiating into distinct subtypes in response to varying microenvironmental cues, thereby performing specializ…
View article: LncRNA FOXP4-AS1 facilitates colorectal cancer invasion and migration by enhancing USP7 interaction with ZEB1 Running title: LncRNA FOXP4-AS1 raises CRC invasion and migration
LncRNA FOXP4-AS1 facilitates colorectal cancer invasion and migration by enhancing USP7 interaction with ZEB1 Running title: LncRNA FOXP4-AS1 raises CRC invasion and migration Open
Colorectal cancer (CRC) poses a threat to the health of people worldwide. Long noncoding RNAs (lncRNAs) have been reported to play a key role in regulating carcinogenesis, including CRC. In this study, the levels of lncRNA forkhead box P4 …
View article: New variants and genotype-phenotype correlation of PPP3CA-related developmental and epileptic encephalopathy
New variants and genotype-phenotype correlation of PPP3CA-related developmental and epileptic encephalopathy Open
Objective To explore the genotypic spectrum and refine the genotype-phenotype correlation of PPP3CA -related developmental and epileptic encephalopathy (DEE). Methods whole-exome sequencing or whole-genome sequencing was performed to all p…
View article: ControlMambaIR: Conditional Controls with State-Space Model for Image Restoration
ControlMambaIR: Conditional Controls with State-Space Model for Image Restoration Open
This paper proposes ControlMambaIR, a novel image restoration method designed to address perceptual challenges in image deraining, deblurring, and denoising tasks. By integrating the Mamba network architecture with the diffusion model, the…
View article: Knowledge, attitudes, and practices of family members of children undergoing chemoradiotherapy regarding oral mucositis
Knowledge, attitudes, and practices of family members of children undergoing chemoradiotherapy regarding oral mucositis Open
Family members of children undergoing chemoradiotherapy have adequate knowledge and positive attitudes about oral mucositis, but this does not always lead to proactive practices. Educational interventions should enhance knowledge and encou…
View article: VISTA attenuates ischemia reperfusion-induced renal injury and fibrosis by macrophage polarization reprogramming
VISTA attenuates ischemia reperfusion-induced renal injury and fibrosis by macrophage polarization reprogramming Open
Renal ischemia reperfusion (IR) injury is one of the major causes of acute kidney injury (AKI) and may contribute to the development of chronic kidney disease. However, the precise immunological mediators orchestrating these pathophysiolog…
View article: MCTR1 ameliorates LPS-induced lung injury by inhibiting neutrophil reverse transendothelial migration
MCTR1 ameliorates LPS-induced lung injury by inhibiting neutrophil reverse transendothelial migration Open
MCTR1 reduces lung damage by upregulating GRK2 to inhibit CXCR4 expression, thereby suppressing neutrophil rTEM in LPS-induced lung injury.
View article: Rapid Detection of AAV8 Binding Antibodies in Gene Therapy Candidates: Development of a Point-of-Care Approach
Rapid Detection of AAV8 Binding Antibodies in Gene Therapy Candidates: Development of a Point-of-Care Approach Open
Preexisting anti-AAV antibodies pose a significant challenge to the success of Adeno-associated Virus (AAV) mediated gene therapies, as they can diminish therapeutic effectiveness, restrict patient eligibility for treatment, and cause seri…
View article: The phenotypic spectrum of <scp> <i>YWHAG</i> </scp> ‐related epilepsy: From mild febrile seizures to severe developmental delay and epileptic encephalopathy
The phenotypic spectrum of <span> <i>YWHAG</i> </span> ‐related epilepsy: From mild febrile seizures to severe developmental delay and epileptic encephalopathy Open
Aim To explore the phenotypic spectrum and refine the genotype–phenotype correlation of YWHAG ‐related epilepsy. Method This study used a retrospective cohort design to evaluate the clinical data of 15 patients with epilepsy and YWHAG vari…
View article: HBCOC attenuates cerebral ischemia-reperfusion injury in mice by inhibiting the inflammatory response and autophagy via TREM-1/ERK/NF-κB
HBCOC attenuates cerebral ischemia-reperfusion injury in mice by inhibiting the inflammatory response and autophagy via TREM-1/ERK/NF-κB Open
We found that the HBCOC treatment alleviated nerve injury and reduced the cerebral infarction area caused by ischemia-reperfusion, simultaneously lowered the expression of IL-1β, IL-6, and TNF-α in plasma and brain tissues. HBCOC suppresse…
View article: Basiliximab for the Treatment of Acute T‐Cell Mediated Rejection After Kidney Transplantation: Case Series and Preliminary Experience
Basiliximab for the Treatment of Acute T‐Cell Mediated Rejection After Kidney Transplantation: Case Series and Preliminary Experience Open
Background The study aims to evaluate the preliminary efficacy and safety of basiliximab in treating acute T cell‐mediated rejection (TCMR) after kidney transplantation, particularly in patients with poor responses to standard treatments. …
View article: Clinical comparative study of the modified superior mesenteric artery approach in total laparoscopic radical resection for right colon cancer - a single-center retrospective study
Clinical comparative study of the modified superior mesenteric artery approach in total laparoscopic radical resection for right colon cancer - a single-center retrospective study Open
The study was approved by the Ethics Committee of The First Affiliated Hospital of Wannan Medical College and registered with the China Clinical Trials Registry (ChiCTR2300075919, Date of Registration:2023-09-19- retrospective registration…
View article: Vitamin B12 deficiency anaemia and gestational diabetes mellitus: a two-sample Mendelian randomization study
Vitamin B12 deficiency anaemia and gestational diabetes mellitus: a two-sample Mendelian randomization study Open
Background: To explore the potential causal relationship between vitamin B12(VitB12) deficiency anaemia and gestational diabetes mellitus(GDM) using a two-sample Mendelian randomization(MR) method. Methods: The VitB12 deficiency anaemia an…
View article: Multimodal near‐infrared molecular imaging of ex vivo endometrial carcinoma via <scp>CD47</scp>‐based targeted tracer
Multimodal near‐infrared molecular imaging of ex vivo endometrial carcinoma via <span>CD47</span>‐based targeted tracer Open
The detection and complete eradication of early‐stage small tumors during hysteroscopy remains a significant clinical challenge in preserving fertility for young women with endometrial cancer (EC). The purpose of this study is to verify th…
View article: Novel long noncoding lncARF mediated hyperhomocysteinemia-induced atherosclerosis via autophagy inhibition in foam cells
Novel long noncoding lncARF mediated hyperhomocysteinemia-induced atherosclerosis via autophagy inhibition in foam cells Open
Our study highlights the mechanisms of lncARF in protecting against the development of atherosclerosis involving the epigenetic modifications and RRAGD/PI3K/Akt and RRAGD/MAPK signaling pathways, which may provide novel diagnostic biomarke…
View article: The regulatory mechanisms of cerium oxide nanoparticles in oxidative stress and emerging applications in refractory wound care
The regulatory mechanisms of cerium oxide nanoparticles in oxidative stress and emerging applications in refractory wound care Open
Cerium oxide nanoparticles (CeNPs) have emerged as a potent therapeutic agent in the realm of wound healing, attributing their efficacy predominantly to their exceptional antioxidant properties. Mimicking the activity of endogenous antioxi…
View article: Rehabilitative treatment of lower leg injury was studied by using anterolateral free thigh flap with CT scan
Rehabilitative treatment of lower leg injury was studied by using anterolateral free thigh flap with CT scan Open
In cases of severe soft tissue loss and deep tissue exposure in the lower part of the leg, microsurgical skin flap transplantation is the primary treatment method. Based on the anatomy of the descending branch of the lateral circumflex fem…
View article: Limb salvage and systemic management of gouty tophi: Case series
Limb salvage and systemic management of gouty tophi: Case series Open
Introduction: Gout is a chronic disease characterized by deposition of monosodium urate crystals. Tophi develop in some individuals with untreated or uncontrolled gout, which leads to ulcerations, cosmetic problems, mechanical obstruction …