Xiaochi Ma
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View article: Theoretical Investigation of the Sensitivity—Q Trade‐off in Terahertz Graphene Metamaterial Sensors via Interdigitated Design and Complex‐Frequency Waves
Theoretical Investigation of the Sensitivity—Q Trade‐off in Terahertz Graphene Metamaterial Sensors via Interdigitated Design and Complex‐Frequency Waves Open
Terahertz (THz) technology holds great promise in biomedical imaging, non‐destructive testing, biosensing, and telecommunications, but its adoption is limited by weak light–matter interactions and strong dissipative losses in conventional …
View article: SARM1 senses dsDNA to promote NAD+ degradation and cell death
SARM1 senses dsDNA to promote NAD+ degradation and cell death Open
Detection of DNA is a fundamental strategy for life to recognize non-self or abnormal-self to subsequently trigger the downstream responses. However, the mechanism underlying DNA sensing is incompletely understood. Here, we show that a key…
View article: Faecalibacterium prausnitzii suppresses ovarian cancer by inducing ferroptosis via phenylalanine metabolism activation
Faecalibacterium prausnitzii suppresses ovarian cancer by inducing ferroptosis via phenylalanine metabolism activation Open
Ovarian cancer (OC) is a highly lethal gynecologic malignancy characterized by limited availability of treatment options and frequent recurrence. The gut microbiota has emerged as a key regulator of tumor progression; however, the anticanc…
View article: Medicine‐Food Homologous <i>Plantago</i> L. in Gastrointestinal Health and Disease: A Review
Medicine‐Food Homologous <i>Plantago</i> L. in Gastrointestinal Health and Disease: A Review Open
Plantago L. (PL) is a notable genus of medicine‐food homologous (MFH) plants, with its primary medicinal components comprising the entire plant and its seeds, which are frequently employed as culinary ingredients. PL is abundant in various…
View article: RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis
RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis Open
Metastasis serves as an indicator of malignancy and is a biological characteristic of carcinomas. Epithelial-mesenchymal transition (EMT) plays a key role in the promotion of tumor invasion and metastasis and in the enhancement of tumor ce…
View article: Association of atrial fibrillation with rapid ventricular response and hospital mortality in intensive care unit: A retrospective cohort study
Association of atrial fibrillation with rapid ventricular response and hospital mortality in intensive care unit: A retrospective cohort study Open
Background Atrial fibrillation (AF) with rapid ventricular response (RVR) is a prevalent condition among critically ill patients, frequently contributing to haemodynamic instability. However, the association between AF with RVR and hospita…
View article: Discovery of soluble epoxide hydrolase inhibitors based on the skeleton of piperine: synthesis, properties, molecular dynamics simulation, and their potentials in acute lung injury
Discovery of soluble epoxide hydrolase inhibitors based on the skeleton of piperine: synthesis, properties, molecular dynamics simulation, and their potentials in acute lung injury Open
Objective: Soluble epoxide hydrolase (sEH) emerges as a target of interest for inflammatory diseases. Piperine is a natural amide alkaloid from Piper nigrum and displays an inhibitory effect toward sEH, its chemical structural transformati…
View article: Rice glycosyltransferase OsDUGT1 is involved in heat stress tolerance by glycosylating flavonoids and regulating flavonoid metabolism
Rice glycosyltransferase OsDUGT1 is involved in heat stress tolerance by glycosylating flavonoids and regulating flavonoid metabolism Open
One significant environmental element influencing the growth and yield of rice ( Oryza sativa L.) is high temperature. Nevertheless, the mechanism by which rice responds to high temperature is not fully understood. A rice glycosyltransfera…
View article: The Role of the Bone Morphogenetic Protein Antagonist Noggin in Nucleus Pulposus Intervertebral Disc Cells
The Role of the Bone Morphogenetic Protein Antagonist Noggin in Nucleus Pulposus Intervertebral Disc Cells Open
Low back pain (LBP) is a significant global health issue, contributing to disability and socioeconomic burdens worldwide. The degeneration of the human intervertebral disc (IVD) is a critical factor in the pathogenesis of LBP. Recent studi…
View article: Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer
Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer Open
Elemene is widely recognized as an effective anti-cancer compound and is routinely administered in Chinese clinical settings for the management of several solid tumors, including non-small cell lung cancer (NSCLC). However, its detailed mo…
View article: The Role of the Bone Morphogenic Protein Agonist Noggin for Nucleus Pulposus Intervertebral Disc Cells
The Role of the Bone Morphogenic Protein Agonist Noggin for Nucleus Pulposus Intervertebral Disc Cells Open
Low back pain (LBP) is a significant global health issue, contributing to considerable disability and socioeconomic burdens. The degeneration of the human intervertebral disc (IVD) is a critical factor in the pathogenesis of LBP. Recent st…
View article: Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease Open
Background The gut virome has been implicated in inflammatory bowel disease (IBD), yet a full understanding of the gut virome in IBD patients, especially across diverse geographic populations, is lacking. Results In this study, we conducte…
View article: Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host Open
Mycobacterium tuberculosis (Mtb) ranks as the most lethal human pathogen, able to fend off repeated attacks by the immune system or medications. PE_PGRS proteins are hallmarks of the pathogenicity of Mtb and contribute to its antigenic div…
View article: Integrative metagenomic and metabolomic analyses reveal the potential of gut microbiota to exacerbate acute pancreatitis
Integrative metagenomic and metabolomic analyses reveal the potential of gut microbiota to exacerbate acute pancreatitis Open
Early dysbiosis in the gut microbiota may contribute to the severity of acute pancreatitis (AP), however, a comprehensive understanding of the gut microbiome, potential pathobionts, and host metabolome in individuals with AP remains elusiv…
View article: RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce EMT in lung cancer
RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce EMT in lung cancer Open
Metastasis serves as a malignant indicator and biological characteristic of pulmonary carcinoma. Epithelial-mesenchymal transition (EMT) plays a pivotal role in facilitating tumor invasion and metastasis, and enhances the aggressiveness of…
View article: A Turn-On Fluorescent Probe for Highly Selective Detection and Visualization of Hydrogen Sulfide in Fungi
A Turn-On Fluorescent Probe for Highly Selective Detection and Visualization of Hydrogen Sulfide in Fungi Open
Hydrogen sulfide (H2S) is a significant actor in the virulence and pathogenicity of fungi. The analysis of endogenous H2S in fungi benefits the prevention and treatment of pathogenic infections. Herein, a H2S-activated turn-on fluorescent …
View article: ROS-dependent catalytic mechanism of melatonin metabolism and its application in the measurement of reactive oxygen
ROS-dependent catalytic mechanism of melatonin metabolism and its application in the measurement of reactive oxygen Open
Melatonin (Mel) is an endogenous active molecule whose metabolism progress significantly influences its bioactivity. However, the detailed metabolic pathway of Mel in the pathological state has not yet been fully illustrated. In this study…
View article: CCDC 2285398: Experimental Crystal Structure Determination
CCDC 2285398: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Event Working Memory Selectively Impairs Dynamic Tracking
Event Working Memory Selectively Impairs Dynamic Tracking Open
To construct and understand the dynamic world, our cognitive system continuously segments the information stream of external environment into discrete events. Events have been suggested as the fundamental unit of our cognitive system in pr…
View article: Tetracyclic triterpenoids as inhibitors of cytochrome P450 3A4 and their quantitative structure activity relationship analysis
Tetracyclic triterpenoids as inhibitors of cytochrome P450 3A4 and their quantitative structure activity relationship analysis Open
The interaction between herbs and clinical drugs is one of the risk factors for adverse drug reactions. In the present study, the inhibitory effects of 47 tetracyclic triterpenoids toward the main drug-metabolizing CYPs in humans were inve…
View article: The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis
The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis Open
P23, historically known as a heat shock protein 90 (HSP90) co-chaperone, exerts some of its critical functions in an HSP90-independent manner, particularly when it translocates into the nucleus. The molecular nature underlying how this HSP…